Neurological Symptoms and Findings in the Course of COVID-19 Pandemic

Aysel Büşra Şişman, Muhammet Duran Bayar, Birgül Baştan, Ayşe Özlem Çokar

During the pandemic pandemic era, it has been revealed that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the newly defined member of the coronavirus family, has effects on the nervous system as well as the respiratory tract and gastrointestinal system. Neurological symptoms of both the central nervous system and the peripheral nervous system have been described in the course of COVID-19. The most encountered neurological symptoms were headache, loss of smell and taste, dizziness, and myalgia, but also stroke, meningitis / encephalitis, encephalopathy, seizures, acute demyelinating encephalomyelitis (ADEM), and Guillain-Barré syndrome have been reported. Although the pathophysiological mechanism is not fully understood, multiple pathways are thought to play a role. It is suggested that SARS-CoV-2 has direct effects on the nervous system and it is involved in activation of inflammation, coagulatıon and immune mediated responses. An increasing number of reported neurological symptoms and findings have revealed that close follow-up of patients in terms of neurological aspects is important. In this review, neurological signs and symptoms that have occurred during the course of COVID-19 were described were described.

Keywords: COVID-19, coronavirus, neurology; SARS-CoV-2

DOI :10.26650/BB/CH22.2020.008.21 IUP :10.26650/BB/CH22.2020.008.21 Full Text (PDF)

COVID-19 Pandemi Seyrinde Nörolojik Semptom ve Bulgular

Aysel Büşra Şişman, Muhammet Duran Bayar, Birgül Baştan, Ayşe Özlem Çokar

Coronavirüs ailesinin yeni tanımlanan üyesi şiddetli akut solunum sendromu koronavirus-2’nin (SARS–CoV–2), solunum yolları ve gastrointestinal sistemin yanısıra sinir sistemi üzerine de etkileri olduğu küresel salgın sürecinde ortaya konmuştur. COVID-19 seyrinde hem santral sinir sistemi hem de periferik sinir sistemine ait nörolojik tablolar tanımlanmıştır. Sıklıkla başağrısı, koku ve tad alma duyusunda kayıp, dizzines ve miyalji gibi nörolojik semptomlar ortaya çıkmış olup yine inme, menenjit/ensefalit, ensefalopati, epilepsi nöbeti, akut demyelinizan ensefalomiyelit (ADEM), Guillain-Barré sendromu da bildirilmiştir. Patofizyolojik mekanizma tam olarak anlaşılmamış olsa da birden çok nedenin rol oynadığı düşünülmektedir. SARS-CoV-2’nin sinir sistemi üzerine direkt etkisi olduğu gibi inflamasyon ve koagulasyon mekanizmalarını aktive ettiği ve yine post-enfeksiyöz immün sistem aracılı etkilerinin olduğu öne sürülmektedir. Giderek artan sayıda bildirilen nörolojik semptom ve bulgular; COVID-19 seyrinde hastaların nörolojik açıdan da yakın takip edilmesinin önemli olduğunu ortaya koymuştur. Bu derlemede COVID-19 seyrinde ortaya çıkan nörolojik bulgu ve semptomlar gözden geçirilmiştir.

Keywords: COVID-19, koronavirüs; nöroloji; SARS-CoV-2

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Covid-19: Molecular and Clinical Approach

CHAPTER

Neurological Symptoms and Findings in the Course of COVID-19 Pandemic

COVID-19 Pandemi Seyrinde Nörolojik Semptom ve Bulgular

References

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