Journal of Child

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Review Article


DOI :10.26650/jchild.2023.878287   IUP :10.26650/jchild.2023.878287    Full Text (PDF)

Current Approach to The Treatment of Infantile Hemangioma

Aybüke Doğan, Emine Ecem Aydoğan, Hikmet Gülşah Tanyıldız

Infantile hemangioma (IH) is the most common benign vascular tumor of the infantile period. Although the etiopathology of IH is not well-known, two primary theories exist. The most accepted theory suggests that maternal hypoxic stress leads to the production of hypoxia inducible factor-1 alpha (HIF-1a), which leads to an increased production of vascular endothelial growth factor (VEGF), GLUT-1, and insulin-like growth factor-2, which induces endothelial cell proliferation. The second theory suggests that endothelial cell proliferation is induced by embolization of placental tissue. Propranolol is a nonselective beta-adrenergic receptor blocker which is used in current mainstay therapy for IH. In this review, we aimed to discuss the efficacy and safety of propranolol in light of current data, including studies at the molecular level.

Keywords: Infantile hemangioma, propranolol, topical timolol
DOI :10.26650/jchild.2023.878287   IUP :10.26650/jchild.2023.878287    Full Text (PDF)

İnfantil Hemanjiomların Tedavisinde Güncel Yaklaşımlar

Aybüke Doğan, Emine Ecem Aydoğan, Hikmet Gülşah Tanyıldız

İnfantil hemanjiyom (İH), süt çocukluğu döneminin en sık görülen benign vasküler tümörüdür. Etyopatogenezi hakkında kesin bir bilgi olmamakla birlikte iki temel teoriden bahsedilebilir. Bu teorilerden en çok kabul göreni maternal hipoksik strese bağlı hipoksiyle indüklenen faktör 1 alpha (HIF1-α) artışının VEGF, GLUT1 ve insülin benzeri büyüme faktörü-2 düzeylerini arttırması ve bunun sonucunda endotelyal hücre proliferasyonunun indüklenmesidir. İkinci teori ise plasental doku embolizasyonu nedeniyle ortaya çıkan endotelyal hücre proliferasyonudur. Propranolol İH’nin güncel medikal tedavisinde birinci basamakta kullanılan bir non selektif beta adrenerjik reseptör blokeridir. Derlememizde propranololün etkinliği ve güvenilirliğini moleküler düzeyde yapılan araştırmaları da göz önünde bulundurarak güncel veriler ışığında sunmayı planladık.

Keywords: İnfantil hemanjiom, propranolol, topikal timolol

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APA

Doğan, A., Aydoğan, E.E., & Gülşah Tanyıldız, H. (2023). Current Approach to The Treatment of Infantile Hemangioma. Journal of Child, 23(1), 89-94. https://doi.org/10.26650/jchild.2023.878287


AMA

Doğan A, Aydoğan E E, Gülşah Tanyıldız H. Current Approach to The Treatment of Infantile Hemangioma. Journal of Child. 2023;23(1):89-94. https://doi.org/10.26650/jchild.2023.878287


ABNT

Doğan, A.; Aydoğan, E.E.; Gülşah Tanyıldız, H. Current Approach to The Treatment of Infantile Hemangioma. Journal of Child, [Publisher Location], v. 23, n. 1, p. 89-94, 2023.


Chicago: Author-Date Style

Doğan, Aybüke, and Emine Ecem Aydoğan and Hikmet Gülşah Tanyıldız. 2023. “Current Approach to The Treatment of Infantile Hemangioma.” Journal of Child 23, no. 1: 89-94. https://doi.org/10.26650/jchild.2023.878287


Chicago: Humanities Style

Doğan, Aybüke, and Emine Ecem Aydoğan and Hikmet Gülşah Tanyıldız. “Current Approach to The Treatment of Infantile Hemangioma.” Journal of Child 23, no. 1 (Apr. 2024): 89-94. https://doi.org/10.26650/jchild.2023.878287


Harvard: Australian Style

Doğan, A & Aydoğan, EE & Gülşah Tanyıldız, H 2023, 'Current Approach to The Treatment of Infantile Hemangioma', Journal of Child, vol. 23, no. 1, pp. 89-94, viewed 19 Apr. 2024, https://doi.org/10.26650/jchild.2023.878287


Harvard: Author-Date Style

Doğan, A. and Aydoğan, E.E. and Gülşah Tanyıldız, H. (2023) ‘Current Approach to The Treatment of Infantile Hemangioma’, Journal of Child, 23(1), pp. 89-94. https://doi.org/10.26650/jchild.2023.878287 (19 Apr. 2024).


MLA

Doğan, Aybüke, and Emine Ecem Aydoğan and Hikmet Gülşah Tanyıldız. “Current Approach to The Treatment of Infantile Hemangioma.” Journal of Child, vol. 23, no. 1, 2023, pp. 89-94. [Database Container], https://doi.org/10.26650/jchild.2023.878287


Vancouver

Doğan A, Aydoğan EE, Gülşah Tanyıldız H. Current Approach to The Treatment of Infantile Hemangioma. Journal of Child [Internet]. 19 Apr. 2024 [cited 19 Apr. 2024];23(1):89-94. Available from: https://doi.org/10.26650/jchild.2023.878287 doi: 10.26650/jchild.2023.878287


ISNAD

Doğan, Aybüke - Aydoğan, EmineEcem - Gülşah Tanyıldız, Hikmet. “Current Approach to The Treatment of Infantile Hemangioma”. Journal of Child 23/1 (Apr. 2024): 89-94. https://doi.org/10.26650/jchild.2023.878287



TIMELINE


Submitted10.02.2021
Accepted13.07.2021
Published Online27.03.2023

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