Journal of Child

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Case Report


DOI :10.26650/jchild.2022.833032   IUP :10.26650/jchild.2022.833032    Full Text (PDF)

Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment

Zehra Yavaş Abalı, Medis Çöllü, Şükran Poyrazoğlu, Firdevs Baş, Fatma Feyza Darendeliler

Subcutaneous fat necrosis (SFN) in infancy is a rare condition and usually presents with panniculitis, especially within the first few weeks of life. These skin lesions may improve spontaneously but the most lifethreatening complication of SFN is severe hypercalcemia. Here, we report the case of an infant with severe hypercalcemia due to SFN. The infant was managed for sepsis and evaluated for nodular erythematous skin lesions, which revealed SFN. Hypercalcemia was severe and unresponsive to the usual treatment regimens. Therefore, bisphosphonate (pamidronate) was used to correct the hypercalcemia. Hypercalcemia is a serious complication in SFN and needs prolonged follow-up. Calcium levels should be monitored regularly in these patients. We report that pamidronate may be appropriate as the first line therapy to treat severe hypercalcemia due to SFN.

Keywords: Subcutaneous fat necrosis, hypercalcemia, bisphosphonate
DOI :10.26650/jchild.2022.833032   IUP :10.26650/jchild.2022.833032    Full Text (PDF)

Subkutan Yağ Nekrozu Olan Süt Çocuğunda Ciddi Hiperkalsemi: Bifosfonat Tedavisi ile Başarılı Yönetim

Zehra Yavaş Abalı, Medis Çöllü, Şükran Poyrazoğlu, Firdevs Baş, Fatma Feyza Darendeliler

Subkutan yağ nekrozu (SYN) nadir görülen bir durumdur ve genellikle yaşamın ilk birkaç haftasında pannikülit ile kendini gösterir. SYN’e bağlı cilt lezyonları kendiliğinden iyileşse de yaşamı tehdit eden şiddetli hiperkalsemi en önemli komplikasyonudur. Sepsis nedeniyle tedavi edilmekte olan yenidoğanda gözlenen nodüler eritemli cilt lezyonları SYN tanısı koydurdu. Olguda gelişen ciddi hiperkalsemi olağan tedavi rejimlerine yanıt vermemişti. Bu nedenle, hiperkalsemiyi düzeltmek için bifosfonat (pamidronat) tedavisi kullanıldı. Hiperkalsemi, SYN’nin ciddi bir komplikasyonudur ve uzun süreli izlem gerektirir. Bu olgularda kalsiyum seviyeleri düzenli olarak takip edilmelidir. Pamidronatın SYN’e bağlı hiperkalsemide güvenlidir ve ciddi hiperkalseminin tedavisinde ilk seçenek olarak tercih edilmelidir

Keywords: subkutan yağ nekrozu, hiperkalsemi, bifosfonat

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APA

Yavaş Abalı, Z., Çöllü, M., Poyrazoğlu, Ş., Baş, F., & Darendeliler, F.F. (2022). Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment. Journal of Child, 22(3), 244-247. https://doi.org/10.26650/jchild.2022.833032


AMA

Yavaş Abalı Z, Çöllü M, Poyrazoğlu Ş, Baş F, Darendeliler F F. Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment. Journal of Child. 2022;22(3):244-247. https://doi.org/10.26650/jchild.2022.833032


ABNT

Yavaş Abalı, Z.; Çöllü, M.; Poyrazoğlu, Ş.; Baş, F.; Darendeliler, F.F. Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment. Journal of Child, [Publisher Location], v. 22, n. 3, p. 244-247, 2022.


Chicago: Author-Date Style

Yavaş Abalı, Zehra, and Medis Çöllü and Şükran Poyrazoğlu and Firdevs Baş and Fatma Feyza Darendeliler. 2022. “Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment.” Journal of Child 22, no. 3: 244-247. https://doi.org/10.26650/jchild.2022.833032


Chicago: Humanities Style

Yavaş Abalı, Zehra, and Medis Çöllü and Şükran Poyrazoğlu and Firdevs Baş and Fatma Feyza Darendeliler. “Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment.” Journal of Child 22, no. 3 (Apr. 2024): 244-247. https://doi.org/10.26650/jchild.2022.833032


Harvard: Australian Style

Yavaş Abalı, Z & Çöllü, M & Poyrazoğlu, Ş & Baş, F & Darendeliler, FF 2022, 'Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment', Journal of Child, vol. 22, no. 3, pp. 244-247, viewed 19 Apr. 2024, https://doi.org/10.26650/jchild.2022.833032


Harvard: Author-Date Style

Yavaş Abalı, Z. and Çöllü, M. and Poyrazoğlu, Ş. and Baş, F. and Darendeliler, F.F. (2022) ‘Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment’, Journal of Child, 22(3), pp. 244-247. https://doi.org/10.26650/jchild.2022.833032 (19 Apr. 2024).


MLA

Yavaş Abalı, Zehra, and Medis Çöllü and Şükran Poyrazoğlu and Firdevs Baş and Fatma Feyza Darendeliler. “Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment.” Journal of Child, vol. 22, no. 3, 2022, pp. 244-247. [Database Container], https://doi.org/10.26650/jchild.2022.833032


Vancouver

Yavaş Abalı Z, Çöllü M, Poyrazoğlu Ş, Baş F, Darendeliler FF. Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment. Journal of Child [Internet]. 19 Apr. 2024 [cited 19 Apr. 2024];22(3):244-247. Available from: https://doi.org/10.26650/jchild.2022.833032 doi: 10.26650/jchild.2022.833032


ISNAD

Yavaş Abalı, Zehra - Çöllü, Medis - Poyrazoğlu, Şükran - Baş, Firdevs - Darendeliler, FatmaFeyza. “Severe Hypercalcemia in an Infant with Subcutaneous Fat Necrosis: Successful Management with Bisphosphonate Treatment”. Journal of Child 22/3 (Apr. 2024): 244-247. https://doi.org/10.26650/jchild.2022.833032



TIMELINE


Submitted29.11.2020
First Revision13.07.2021
Last Revision22.09.2021
Accepted27.09.2021
Published Online20.12.2022

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