Research Article


DOI :10.26650/EurJBiol.2020.0077   IUP :10.26650/EurJBiol.2020.0077    Full Text (PDF)

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Ebru DeveciGülsen Tel ÇayanSerdar KarakurtMehmet Emin Duru

Objective: The aim of this study was to investigate antioxidant, enzyme inhibitory and cytotoxic activities of Agropyron repens and Crataegus monogyna methanol extracts with total phenolic and flavonoid contents. Materials and Methods: Total phenolic and flavonoid contents of A. repens and C. monogyna methanol extracts were measured according to Folin Ciocalteu and aluminum nitrate methods, respectively. Antioxidant and enzyme inhibitory activities of the methanol extracts were tested spectrophotometrically. Also, cytotoxic activities of the methanol extracts against DLD-1 and CCD-18Co were investigated by using Alamar Blue assay. Results: C. monogyna methanol extract with the highest total phenolic and flavonoid contents (68.13±0.34 µg GAEs/mg extract and 36.91±0.17 µg QEs/mg extract, respectively) had the best antioxidant activity in β-carotene-linoleic acid (IC50: 32.72±0.15 µg/mL), CUPRAC (A0.50: 282.69±0.25 µg/mL), DPPH• (IC50: 71.69±0.85 µg/mL), and ABTS•+ (IC50: 40.43±0.55 µg/ mL) assays. A. repens methanol extract showed the highest effect against AChE (18.73±0.47 %), BChE (37.59±1.07 %), urease (89.18±0.84%), α-glucosidase (6.71±0.23 %), whereas C. monogyna methanol extract showed the highest effect against tyrosinase (30.52±1.00%) and α-amylase (37.24±0.06 %). Also, A. repens (IC50: 57.38 µg/mL) and C. monogyna (IC50: 54.04 µg/ mL) methanol extracts showed close cytotoxic activity on DLD-1. Conclusion: Antioxidant, cytotoxic, and enzyme inhibitory activities of A. repens and C. monogyna methanol extracts were investigated with total phenolic and flavonoid contents in this study. The results obtained with this study strengthen the potential of the studied plants as a new source for the discovery of antioxidant, cytotoxic, and enzyme inhibitor agents.


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Citations

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APA

Deveci, E., Tel Çayan, G., Karakurt, S., & Duru, M.E. (2020). Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species. European Journal of Biology, 79(2), 98-105. https://doi.org/10.26650/EurJBiol.2020.0077


AMA

Deveci E, Tel Çayan G, Karakurt S, Duru M E. Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species. European Journal of Biology. 2020;79(2):98-105. https://doi.org/10.26650/EurJBiol.2020.0077


ABNT

Deveci, E.; Tel Çayan, G.; Karakurt, S.; Duru, M.E. Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species. European Journal of Biology, [Publisher Location], v. 79, n. 2, p. 98-105, 2020.


Chicago: Author-Date Style

Deveci, Ebru, and Gülsen Tel Çayan and Serdar Karakurt and Mehmet Emin Duru. 2020. “Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species.” European Journal of Biology 79, no. 2: 98-105. https://doi.org/10.26650/EurJBiol.2020.0077


Chicago: Humanities Style

Deveci, Ebru, and Gülsen Tel Çayan and Serdar Karakurt and Mehmet Emin Duru. Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species.” European Journal of Biology 79, no. 2 (Apr. 2024): 98-105. https://doi.org/10.26650/EurJBiol.2020.0077


Harvard: Australian Style

Deveci, E & Tel Çayan, G & Karakurt, S & Duru, ME 2020, 'Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species', European Journal of Biology, vol. 79, no. 2, pp. 98-105, viewed 24 Apr. 2024, https://doi.org/10.26650/EurJBiol.2020.0077


Harvard: Author-Date Style

Deveci, E. and Tel Çayan, G. and Karakurt, S. and Duru, M.E. (2020) ‘Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species’, European Journal of Biology, 79(2), pp. 98-105. https://doi.org/10.26650/EurJBiol.2020.0077 (24 Apr. 2024).


MLA

Deveci, Ebru, and Gülsen Tel Çayan and Serdar Karakurt and Mehmet Emin Duru. Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species.” European Journal of Biology, vol. 79, no. 2, 2020, pp. 98-105. [Database Container], https://doi.org/10.26650/EurJBiol.2020.0077


Vancouver

Deveci E, Tel Çayan G, Karakurt S, Duru ME. Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species. European Journal of Biology [Internet]. 24 Apr. 2024 [cited 24 Apr. 2024];79(2):98-105. Available from: https://doi.org/10.26650/EurJBiol.2020.0077 doi: 10.26650/EurJBiol.2020.0077


ISNAD

Deveci, Ebru - Tel Çayan, Gülsen - Karakurt, Serdar - Duru, MehmetEmin. Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species”. European Journal of Biology 79/2 (Apr. 2024): 98-105. https://doi.org/10.26650/EurJBiol.2020.0077



TIMELINE


Submitted27.10.2020
Accepted25.11.2020
Published Online13.12.2020

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