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DOI :10.26650/experimed.2020.0048   IUP :10.26650/experimed.2020.0048    Full Text (PDF)

Betulinic Acid and its Anticancer Effects

Merve Nur Ataş, Hayriye Arzu Ergen

In recent years, interest in naturally occurring compounds in plants has been increasing. Due to the benefits of these compounds, various studies have been carried out for their therapeutic use in cancer treatment as well as in daily use. These studies have aimed to develop chemotherapeutics that are natural and can stimulate apoptosis due to the side effects of chemotherapeutics used in current cancer treatments. One of these compounds, betulinic acid, is lupane-type pentacyclic triterpenoid, a secondary metabolite found in the bark of various trees. Betulinic acid has strong anticancer properties as well as antiviral and anti-inflammatory effects. It performs its anticancer functions by promoting the mitochondrial apoptosis, regulating cell cycle and angiogenesis, and activating or deactivating many pathways which are important for cancer development. Molecules that directly affect mitochondria such as betulinic acid, hold great promise in preventing drug resistance that may occur in the treatment process. In addition, the fact that betulinic acid directly affects cancer cells and has no toxic effect on healthy cells makes it a potential anticancer molecule in developing chemotherapy strategies. This review aims to discuss the structural and biological properties of betulinic acid and the anticancer effects in various cancer types.

Keywords: Betulinic acid, cancer, apoptosis
DOI :10.26650/experimed.2020.0048   IUP :10.26650/experimed.2020.0048    Full Text (PDF)

Betülinik Asit ve Antikanser Etkileri

Merve Nur Ataş, Hayriye Arzu Ergen

Son yıllarda, bitkilerin yapısında doğal olarak bulunan bileşiklere duyulan ilgi giderek artmaktadır. Bu bileşiklerin sağladıkları faydalar nedeniyle günlük kullanımın yanı sıra kanser tedavisinde terapötik olarak kullanılmasına yönelik çeşitli çalışmalar yapılmaktadır. Bu çalışmalar, güncel kanser tedavilerinde kullanılan kemoterapötiklerin ortaya çıkardığı yan etkiler nedeniyle doğal kaynaklı ve apoptozu uyarabilen kemoterapötiklerin geliştirilmesini amaçlamaktadır. Bu bileşiklerden biri olan betülinik asit, lupan tipi pentasiklik triterpenoid olup çeşitli ağaçların kabuklarında bulunan bir sekonder metabolittir. Betülinik asit, antiviral ve antiinflamatuvar etkiler gibi biyolojik aktivitelerin yanı sıra güçlü bir antikanser aktiviteye sahiptir. Bu antikanser aktivitesini, mitokondriyal apoptozu teşvik ederek, hücre siklusunu ve anjiyogenezi düzenleyerek ve kanser gelişimi için önemli birçok yolağı aktive veya inaktive ederek gerçekleştirir. Betülinik asit gibi doğrudan mitokondriyi etkileyen moleküller, tedavi sürecinde oluşabilecek ilaç direncini engellemek için büyük umut vaad etmektedir. Ayrıca betülinik asidin kanser hücrelerini doğrudan etkileyip sağlıklı hücrelere karşı toksik etkisinin olmaması geliştirilmekte olan kemoterapi stratejilerinde onu potansiyel antikanser molekül haline getirmektedir. Bu derlemede, betülinik asidin yapısal ve biyolojik özellikleri ile çeşitli kanser türlerindeki antikanser etkilerinin tartışılması amaçlanmaktadır

Keywords: Betülinik asit, kanser, apoptoz

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APA

Ataş, M.N., & Ergen, H.A. (2020). Betulinic Acid and its Anticancer Effects. Experimed, 10(3), 128-134. https://doi.org/10.26650/experimed.2020.0048


AMA

Ataş M N, Ergen H A. Betulinic Acid and its Anticancer Effects. Experimed. 2020;10(3):128-134. https://doi.org/10.26650/experimed.2020.0048


ABNT

Ataş, M.N.; Ergen, H.A. Betulinic Acid and its Anticancer Effects. Experimed, [Publisher Location], v. 10, n. 3, p. 128-134, 2020.


Chicago: Author-Date Style

Ataş, Merve Nur, and Hayriye Arzu Ergen. 2020. “Betulinic Acid and its Anticancer Effects.” Experimed 10, no. 3: 128-134. https://doi.org/10.26650/experimed.2020.0048


Chicago: Humanities Style

Ataş, Merve Nur, and Hayriye Arzu Ergen. “Betulinic Acid and its Anticancer Effects.” Experimed 10, no. 3 (Apr. 2024): 128-134. https://doi.org/10.26650/experimed.2020.0048


Harvard: Australian Style

Ataş, MN & Ergen, HA 2020, 'Betulinic Acid and its Anticancer Effects', Experimed, vol. 10, no. 3, pp. 128-134, viewed 20 Apr. 2024, https://doi.org/10.26650/experimed.2020.0048


Harvard: Author-Date Style

Ataş, M.N. and Ergen, H.A. (2020) ‘Betulinic Acid and its Anticancer Effects’, Experimed, 10(3), pp. 128-134. https://doi.org/10.26650/experimed.2020.0048 (20 Apr. 2024).


MLA

Ataş, Merve Nur, and Hayriye Arzu Ergen. “Betulinic Acid and its Anticancer Effects.” Experimed, vol. 10, no. 3, 2020, pp. 128-134. [Database Container], https://doi.org/10.26650/experimed.2020.0048


Vancouver

Ataş MN, Ergen HA. Betulinic Acid and its Anticancer Effects. Experimed [Internet]. 20 Apr. 2024 [cited 20 Apr. 2024];10(3):128-134. Available from: https://doi.org/10.26650/experimed.2020.0048 doi: 10.26650/experimed.2020.0048


ISNAD

Ataş, MerveNur - Ergen, HayriyeArzu. “Betulinic Acid and its Anticancer Effects”. Experimed 10/3 (Apr. 2024): 128-134. https://doi.org/10.26650/experimed.2020.0048



TIMELINE


Submitted27.08.2020
Accepted28.09.2020
Published Online25.12.2020

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