Research Article


DOI :10.26650/IstanbulJPharm.2020.0086   IUP :10.26650/IstanbulJPharm.2020.0086    Full Text (PDF)

Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones

Zekiye Şeyma SevinçliZerrin CantürkMiriş DikmenNilgün Lütfiye Karalı

Background and Aims: The aim of this study was to screen the in vitro anticancer/antituberculosis activities of 5-fluoro1-methyl/ethyl-1H-indole-2,3-dione 3-thiosemicarbazones. Methods: A549/U-87MG cell lines were used for the anticancer activity of the compounds, while CCD-19Lu cell line was used to determine their cytotoxic effects. In antituberculosis activity studies using MTB H37Rv cell line, BJ cell line was used to determine the cytotoxic effects. MTT assay was used to obtain IC50 values. Results: 6a, 6b, 6g, 6h, 6l, 6n, 7c, 7k and 7l were found to be highly effective against A549 cell line compared to cisplatin whereas 6d, 6h, 6l, 6n, 7d and 7f were found to be effective against U-87MG cell line compared to cisplatin. It was also determined that 6a, 6b and 7l did not show cytotoxic effects on CCD-19Lu cell line. The antituberculosis effects of the compounds were investigated against MTB H37Rv cell groups using rifampicin as standard. It was determined that 6b, 6c, 6g-k, 6n, 7b, 7j and 7l have near-standard activity and 6b, 7b and 7l were not cytotoxic on BJ cell line. Conclusion: While determining effective compounds in anticancer studies, it was concluded that active compounds can be reached by modifications in compounds in antituberculosis studies.


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APA

Sevinçli, Z.Ş., Cantürk, Z., Dikmen, M., & Karalı, N.L. (2020). Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones. İstanbul Journal of Pharmacy, 50(3), 176-180. https://doi.org/10.26650/IstanbulJPharm.2020.0086


AMA

Sevinçli Z Ş, Cantürk Z, Dikmen M, Karalı N L. Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones. İstanbul Journal of Pharmacy. 2020;50(3):176-180. https://doi.org/10.26650/IstanbulJPharm.2020.0086


ABNT

Sevinçli, Z.Ş.; Cantürk, Z.; Dikmen, M.; Karalı, N.L. Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones. İstanbul Journal of Pharmacy, [Publisher Location], v. 50, n. 3, p. 176-180, 2020.


Chicago: Author-Date Style

Sevinçli, Zekiye Şeyma, and Zerrin Cantürk and Miriş Dikmen and Nilgün Lütfiye Karalı. 2020. “Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones.” İstanbul Journal of Pharmacy 50, no. 3: 176-180. https://doi.org/10.26650/IstanbulJPharm.2020.0086


Chicago: Humanities Style

Sevinçli, Zekiye Şeyma, and Zerrin Cantürk and Miriş Dikmen and Nilgün Lütfiye Karalı. Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones.” İstanbul Journal of Pharmacy 50, no. 3 (Apr. 2024): 176-180. https://doi.org/10.26650/IstanbulJPharm.2020.0086


Harvard: Australian Style

Sevinçli, ZŞ & Cantürk, Z & Dikmen, M & Karalı, NL 2020, 'Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones', İstanbul Journal of Pharmacy, vol. 50, no. 3, pp. 176-180, viewed 27 Apr. 2024, https://doi.org/10.26650/IstanbulJPharm.2020.0086


Harvard: Author-Date Style

Sevinçli, Z.Ş. and Cantürk, Z. and Dikmen, M. and Karalı, N.L. (2020) ‘Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones’, İstanbul Journal of Pharmacy, 50(3), pp. 176-180. https://doi.org/10.26650/IstanbulJPharm.2020.0086 (27 Apr. 2024).


MLA

Sevinçli, Zekiye Şeyma, and Zerrin Cantürk and Miriş Dikmen and Nilgün Lütfiye Karalı. Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones.” İstanbul Journal of Pharmacy, vol. 50, no. 3, 2020, pp. 176-180. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2020.0086


Vancouver

Sevinçli ZŞ, Cantürk Z, Dikmen M, Karalı NL. Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones. İstanbul Journal of Pharmacy [Internet]. 27 Apr. 2024 [cited 27 Apr. 2024];50(3):176-180. Available from: https://doi.org/10.26650/IstanbulJPharm.2020.0086 doi: 10.26650/IstanbulJPharm.2020.0086


ISNAD

Sevinçli, ZekiyeŞeyma - Cantürk, Zerrin - Dikmen, Miriş - Karalı, NilgünLütfiye. Anticancer and antituberculosis effects of 5-fluoro1H-indole-2,3-dione 3-thiosemicarbazones”. İstanbul Journal of Pharmacy 50/3 (Apr. 2024): 176-180. https://doi.org/10.26650/IstanbulJPharm.2020.0086



TIMELINE


Submitted08.09.2020
Accepted18.11.2020
Published Online31.12.2020

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