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DOI :10.26650/JARHS2021-795999   IUP :10.26650/JARHS2021-795999    Full Text (PDF)

Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases

Şafak Ceren Uçak, Dilek Şatana

Candida glabrata is a yeast genus fungus that can be found in the normal flora of healthy individuals and can lead to various infections in humans. Candida species cause local infections as well as fatal systemic infections. Recent years have seen an increase in the isolation rate of non-Candida albicans species, especially Candida glabrata. The most important reason for this increase is the change in factor distribution with prophylactic and empirical use of fluconazole. There are articles in the world and in our country reporting that the second isolation frequency after C. albicans is Candida glabrata. Unlike other Candida species, C. glabrata are not dimorphic; C. glabrata are found both commensally and pathogenically as blastoconidia. C. glabrata infections are difficult to treat and are often resistant to many azole antifungal agents, especially fluconazole. As a result, C. glabrata infections are among infections with a high mortality rate.

Keywords: Candida glabrata, epidemiology, virulence factors, laboratory diagnosis
DOI :10.26650/JARHS2021-795999   IUP :10.26650/JARHS2021-795999    Full Text (PDF)

Candida glabrata: Laboratuvar Tanısı ve Mikrobiyolojik Özellikleri, Epidemiyolojisi, Virulans Faktörleri ve Klinik Hastalıkları

Şafak Ceren Uçak, Dilek Şatana

Candida glabrata, sağlıklı bireylerin normal florasında bulunabilen ve insanlarda çeşitli enfeksiyonlara yol açabilen maya cinsi bir mantardır. Candida türleri lokal enfeksiyonların yanı sıra ölümcül seyreden sistemik enfeksiyonlara da neden olmaktadır. Son yıllarda Candida albicans dışı türlerin, özellikle de C. glabrata izolasyon oranında artış görülmektedir. Bu artışın en önemli nedeni, flukonazolün profilaktik ve ampirik olarak kullanımı ile etken dağılımının değişmesidir. Dünyada ve ülkemizde C. glabrata’nın C. albicans’tan sonra 2. sıklıkta izole edilen tür olduğunu bildiren çalışmalar bulunmaktadır. Diğer Candida türlerinin aksine, C. glabrata dimorfik değildir hem komensal hem de patojen olarak blastokonidia yapısına sahiptir. C. glabrata enfeksiyonlarının tedavisi zordur ve sıklıkla birçok azol grubu antifungal ilaca, özellikle flukonazole dirençlidir. Sonuç olarak, C. glabrata enfeksiyonları ölüm oranı yüksek enfeksiyonlar arasındadır.

Keywords: Candida glabrata, epidemiyoloji, virulans faktörleri, laboratuvar tanısı

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APA

Uçak, Ş.C., & Şatana, D. (2021). Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases. Journal of Advanced Research in Health Sciences, 4(1), 31-39. https://doi.org/10.26650/JARHS2021-795999


AMA

Uçak Ş C, Şatana D. Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases. Journal of Advanced Research in Health Sciences. 2021;4(1):31-39. https://doi.org/10.26650/JARHS2021-795999


ABNT

Uçak, Ş.C.; Şatana, D. Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 4, n. 1, p. 31-39, 2021.


Chicago: Author-Date Style

Uçak, Şafak Ceren, and Dilek Şatana. 2021. “Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases.” Journal of Advanced Research in Health Sciences 4, no. 1: 31-39. https://doi.org/10.26650/JARHS2021-795999


Chicago: Humanities Style

Uçak, Şafak Ceren, and Dilek Şatana. “Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases.” Journal of Advanced Research in Health Sciences 4, no. 1 (Apr. 2024): 31-39. https://doi.org/10.26650/JARHS2021-795999


Harvard: Australian Style

Uçak, ŞC & Şatana, D 2021, 'Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases', Journal of Advanced Research in Health Sciences, vol. 4, no. 1, pp. 31-39, viewed 25 Apr. 2024, https://doi.org/10.26650/JARHS2021-795999


Harvard: Author-Date Style

Uçak, Ş.C. and Şatana, D. (2021) ‘Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases’, Journal of Advanced Research in Health Sciences, 4(1), pp. 31-39. https://doi.org/10.26650/JARHS2021-795999 (25 Apr. 2024).


MLA

Uçak, Şafak Ceren, and Dilek Şatana. “Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases.” Journal of Advanced Research in Health Sciences, vol. 4, no. 1, 2021, pp. 31-39. [Database Container], https://doi.org/10.26650/JARHS2021-795999


Vancouver

Uçak ŞC, Şatana D. Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases. Journal of Advanced Research in Health Sciences [Internet]. 25 Apr. 2024 [cited 25 Apr. 2024];4(1):31-39. Available from: https://doi.org/10.26650/JARHS2021-795999 doi: 10.26650/JARHS2021-795999


ISNAD

Uçak, ŞafakCeren - Şatana, Dilek. “Candida glabrata: Laboratory Diagnosis and Microbiological Characteristics, Epidemiology, Virulence Factors and Clinical Diseases”. Journal of Advanced Research in Health Sciences 4/1 (Apr. 2024): 31-39. https://doi.org/10.26650/JARHS2021-795999



TIMELINE


Submitted16.09.2020
Accepted20.01.2021
Published Online25.02.2021

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