Journal of Advanced Research in Health Sciences

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DOI :10.26650/JARHS2021-843387   IUP :10.26650/JARHS2021-843387    Full Text (PDF)

Coronary Artery Disease Severity and Platelet Aggregation

Gülsel Ayaz, Bilgehan Karadağ, Mehmet Güven, Gönül Kanıgür, Ahmet Dirican, Barış İlerigelen, Turgut Ulutin

Objective: Coronary Artery Disease (CAD) is caused by the narrowing or occlusion of the vessels feeding the heart, mostly due to atherosclerosis. In the pathogenesis of atherosclerosis, besides atherosclerotic risk factors, inflammation, endothelial dysfunction and related platelet activation are frequently observed. While there are studies investigating platelet functions in CAD, studies on the relationship between disease severity and platelet activation are limited. In this study, we aimed to investigate the relationship between the number of occluded vessels and platelet functions. Materials and Methods: The cases of CAD with vascular occlusion detected by coronary angiography were divided into 3 subgroups according to disease severity. The platelet aggregation test with Adenosindiphosphate (ADP) stimulation was applied to the CAD and healthy controls with the Light Transmittance Aggregometry (LTA) method. The results of that test were calculated as aggregation curve slope and % Amplitude. Results: In the platelet aggregation test, although the CAD aggregation slope values (116.90±28.21a ) were higher than the control (113.90±35.16a ) there was no statistically significant difference (p=0.526a ). Although % Amplitude values were higher in the control group (74.73±30.71a ) compared to the CAD group (66.51±25.18a ) there was no statistical significance between them (p=0.056a ). There was no statistically significant difference between aggregation slope and % Amplitude values of the CAD subgroups (Slope p=0.461b , % Amplitude p=0.140c ). Conclusion: In this study, in which we evaluated the results of ADP-induced aggregation tests according to the severity of the disease in CAD cases, no statistically significant relationship was found between the number of vascular occlusion and the results of the aggregation test.

Keywords: Platelet, Coronary Artery Disease, ADP, Platelet aggregation
DOI :10.26650/JARHS2021-843387   IUP :10.26650/JARHS2021-843387    Full Text (PDF)

Koroner Arter Hastalığı Şiddeti ve Trombosit Agregasyonu

Gülsel Ayaz, Bilgehan Karadağ, Mehmet Güven, Gönül Kanıgür, Ahmet Dirican, Barış İlerigelen, Turgut Ulutin

Amaç: Koroner Arter Hastalığı (KAH), çoğunlukla ateroskleroz sebebiyle kalbi besleyen damarların daralması veya tıkanması ile ortaya çıkmaktadır. Ateroskleroz patogenezinde aterosklerotik risk faktörlerinin yanı sıra inflamasyon, endotel disfonksiyonu ve buna bağlı olarak trombosit aktivasyonu sıklıkla görülmektedir. KAH’da trombosit fonksiyonlarını araştıran çalışmalar olmasına rağmen, hastalık şiddeti ile trombosit aktivasyonu arasındaki ilişkiye dair çalışmalar kısıtlıdır. Bu çalışmada, tıkalı damar sayısı ile trombosit fonksiyonları arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Koroner anjiyografi ile damar tıkanıklığı tespit edilen KAH olguları, hastalık şiddetine göre 3 alt gruba ayrıldı. Işık geçirgenliği agregometri (LTA) yöntemi ile KAH ve sağlıklı kontrollere adenozindifosfat (ADP) uyaranı ile trombosit agregasyon testi uygulandı. Trombosit agregasyon testinin sonuçları, agregasyon kurbu eğimi ohm (Ώ) ve agregasyonun maksimum kapsamı yüzde (%) Amplitüd olarak hesaplandı. Bulgular: Trombosit agregasyon testinde KAH agregasyon eğim değerleri (116,90±28,21a ) kontrole göre (113,90±35,16a ) yüksek olmasına rağmen aralarında istatistiksel olarak bir farklılık yoktur (p=0,526a ). (%) Amplitüd değerleri kontrol grubunda (74,73±30,71a ), KAH grubuna göre (66,51±25,18a ) yüksek olmasına rağmen aralarında istatistiksel olarak anlamlılık bulunmamaktadır (p=0,056a ). KAH alt gruplarının agregasyon eğim (Ώ) ve (%) Amplitüd değerleri arasında istatistiksel olarak bir fark saptanmamıştır (Eğim (Ώ) p=0,461b , (%) Amplitüd p=0,140c ). Sonuç: KAH olgularında, ADP aracılı agregasyon testi sonuçlarını hastalık şiddetine göre değerlendirdiğimiz bu çalışmada, damar tıkanıklığı sayısı ile agregasyon testi sonuçları arasında istatistiksel olarak anlamlı bir ilişki saptanmamıştır.

Keywords: Trombosit, Koroner Arter Hastalığı, ADP, Trombosit agregasyonu

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APA

Ayaz, G., Karadağ, B., Güven, M., Kanıgür, G., Dirican, A., İlerigelen, B., & Ulutin, T. (2021). Coronary Artery Disease Severity and Platelet Aggregation. Journal of Advanced Research in Health Sciences, 4(1), 13-19. https://doi.org/10.26650/JARHS2021-843387


AMA

Ayaz G, Karadağ B, Güven M, Kanıgür G, Dirican A, İlerigelen B, Ulutin T. Coronary Artery Disease Severity and Platelet Aggregation. Journal of Advanced Research in Health Sciences. 2021;4(1):13-19. https://doi.org/10.26650/JARHS2021-843387


ABNT

Ayaz, G.; Karadağ, B.; Güven, M.; Kanıgür, G.; Dirican, A.; İlerigelen, B.; Ulutin, T. Coronary Artery Disease Severity and Platelet Aggregation. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 4, n. 1, p. 13-19, 2021.


Chicago: Author-Date Style

Ayaz, Gülsel, and Bilgehan Karadağ and Mehmet Güven and Gönül Kanıgür and Ahmet Dirican and Barış İlerigelen and Turgut Ulutin. 2021. “Coronary Artery Disease Severity and Platelet Aggregation.” Journal of Advanced Research in Health Sciences 4, no. 1: 13-19. https://doi.org/10.26650/JARHS2021-843387


Chicago: Humanities Style

Ayaz, Gülsel, and Bilgehan Karadağ and Mehmet Güven and Gönül Kanıgür and Ahmet Dirican and Barış İlerigelen and Turgut Ulutin. “Coronary Artery Disease Severity and Platelet Aggregation.” Journal of Advanced Research in Health Sciences 4, no. 1 (Apr. 2024): 13-19. https://doi.org/10.26650/JARHS2021-843387


Harvard: Australian Style

Ayaz, G & Karadağ, B & Güven, M & Kanıgür, G & Dirican, A & İlerigelen, B & Ulutin, T 2021, 'Coronary Artery Disease Severity and Platelet Aggregation', Journal of Advanced Research in Health Sciences, vol. 4, no. 1, pp. 13-19, viewed 19 Apr. 2024, https://doi.org/10.26650/JARHS2021-843387


Harvard: Author-Date Style

Ayaz, G. and Karadağ, B. and Güven, M. and Kanıgür, G. and Dirican, A. and İlerigelen, B. and Ulutin, T. (2021) ‘Coronary Artery Disease Severity and Platelet Aggregation’, Journal of Advanced Research in Health Sciences, 4(1), pp. 13-19. https://doi.org/10.26650/JARHS2021-843387 (19 Apr. 2024).


MLA

Ayaz, Gülsel, and Bilgehan Karadağ and Mehmet Güven and Gönül Kanıgür and Ahmet Dirican and Barış İlerigelen and Turgut Ulutin. “Coronary Artery Disease Severity and Platelet Aggregation.” Journal of Advanced Research in Health Sciences, vol. 4, no. 1, 2021, pp. 13-19. [Database Container], https://doi.org/10.26650/JARHS2021-843387


Vancouver

Ayaz G, Karadağ B, Güven M, Kanıgür G, Dirican A, İlerigelen B, Ulutin T. Coronary Artery Disease Severity and Platelet Aggregation. Journal of Advanced Research in Health Sciences [Internet]. 19 Apr. 2024 [cited 19 Apr. 2024];4(1):13-19. Available from: https://doi.org/10.26650/JARHS2021-843387 doi: 10.26650/JARHS2021-843387


ISNAD

Ayaz, Gülsel - Karadağ, Bilgehan - Güven, Mehmet - Kanıgür, Gönül - Dirican, Ahmet - İlerigelen, Barış - Ulutin, Turgut. “Coronary Artery Disease Severity and Platelet Aggregation”. Journal of Advanced Research in Health Sciences 4/1 (Apr. 2024): 13-19. https://doi.org/10.26650/JARHS2021-843387



TIMELINE


Submitted21.12.2020
Accepted20.01.2021
Published Online25.02.2021

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