Journal of Istanbul Faculty of Medicine

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DOI :10.26650/IUITFD.2019.0090   IUP :10.26650/IUITFD.2019.0090    Full Text (PDF)

SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS

Zuhal Bayramoğlu, Oya Köker, Sedat Giray Kandemirli, İbrahim Adaletli, Rukiye Eker Ömeroğlu

Objective: The aim of this study is to investigate the effects of recurrent inflammation and amyloid deposition on salivary and thyroid gland elasticity in pediatric patients with Familial Mediterranean Fever (FMF) using shear wave ultrasound elastography.

Material and Method: This study included 31 patients with a diagnosis of FMF. At the time of imaging, 22 patients were admitted to the rheumatology department with an acute attack (45% girls, mean age±SD: 13.3±4.6 years). The remaining nine patients had histopathologically proven amyloidosis (50% girls, mean age±SD: 17.4±7.1 years). The control group comprised 40 healthy children (50% girls; mean age: 11.6±4.6 years). Shear wave elastography (SWE) measurements of the bilateral parotid, submandibular and thyroid glands were performed.

Results: The median shear wave elasticity and velocity values of the salivary and thyroid glands in FMF patients imaged during an acute attack and patients with amyloidosis were significantly higher compared to the normal control subjects. However, the elastography values between FMF patients imaged during acute attack and patients with amyloidosis were not significantly different. The cut–off values for differentiation of patients with FMF from control subjects were 9.1 kPa, 9 kPa and 9.9 kPa for parotid, submandibular and thyroid glands, respectively. There were moderate negative correlations between thyroid (r=-0.6, p=0.008) and parotid gland (r=-0.4; p=0.04) elasticity with C-re active protein and between serum amyloid A with thyroid gland elasticity (r=-0.58, p=0.018).

Conclusion: Both acute inflammation and amyloid deposition would contribute to increased tissue stiffness. SWE might reflect clinically occult changes in salivary and thyroid glands that could not be demonstrated by routine gray scale ultrasonography in patients with FMF.

Keywords: Children, shear wave elastography, amyloidosis
DOI :10.26650/IUITFD.2019.0090   IUP :10.26650/IUITFD.2019.0090    Full Text (PDF)

FMF VE AMİLOİDOZ TANISI ALAN PEDİATRİK HASTALARDA TÜKÜRÜK VE TİROİD BEZLERİNDE SHEAR WAVE ELASTOGRAFİ DEĞERLENDİRME

Zuhal Bayramoğlu, Oya Köker, Sedat Giray Kandemirli, İbrahim Adaletli, Rukiye Eker Ömeroğlu

Amaç: Bu çalışmanın amacı, Ailevi Akdeniz Ateşi (FMF) tanısı olan çocuk hastalarda tekrarlayan inflamasyon ve amiloid birikiminin tükrük ve tiroid bezi doku sertliği üzerindeki etkilerini araştırmaktır.

Gereç ve Yöntem: Bu çalışma FMF tanısı almış 31 hastayı içermekteydi. Görüntüleme sırasında, 22 FMF hastası akut atak ile romatoloji kliniğine yatırıldı (%45 kız, yaş ort.±SS: 13,3±4,6 yıl). Kalan 9 hasta histopatolojik olarak amiloidoz tanısı almıştı (%50 kız, yaş ort.±SS: 17,4±7,1 yıl). Kontrol grubu 40 sağlıklı çocuk (%50 kız; ort. yaş: 11,6±4,6 yıl) içermekteydi. Her iki parotis, submandibular ve tiroid bezlerine shear wave elastografi ile değerlendirme yapıldı.

Bulgular: Akut atak sırasında görüntülenen FMF hastalarında ve amiloidoz hastalarında tükürük ve tiroid bezlerinin ortanca shear wave elastikiyet ve hız değerleri normal kontrol grubuna göre anlamlı derecede yüksek bulundu.Elastografi değerleri akut atak ve amiloidoz grubu arasında istatistiksel olarak anlamlı farklılık oluşturmamaktaydı. Kontrol grubu ile FMF’li hastalar arasındaki eşik değerleri parotis, submandibular ve tiroid bezleri için sırasıyla 9,1 kPa, 9 kPa ve 9,9 kPa idi. Tiroid (r=-0,6, p=0,008) ve parotis bezi (r=-0,4; p=0,04) esneklik değerleri ile C-reaktif protein arasında , ve serum amiloid A ile tiroid bezi esnekliği (r=-0,58, p=0,018) arasında orta dereceli negatif korelasyon mevcuttu.

Sonuç: Hem akut enflamasyon hem de amiloid birikimi, doku sertliğinin artmasına katkıda bulunabilir. SWE FMF’li hastalarda tükürük ve tiroid bezlerinde rutin gri skala ultrasonografi ile gösterilemeyen ve kliniğe henüz yansımamış değişiklikleri ortaya çıkarabilir.

Keywords: Çocuk, shear wave elastografi, amiloidoz

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APA

Bayramoğlu, Z., Köker, O., Kandemirli, S.G., Adaletli, İ., & Eker Ömeroğlu, R. (2020). SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS. Journal of Istanbul Faculty of Medicine, 83(2), 92-99. https://doi.org/10.26650/IUITFD.2019.0090


AMA

Bayramoğlu Z, Köker O, Kandemirli S G, Adaletli İ, Eker Ömeroğlu R. SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS. Journal of Istanbul Faculty of Medicine. 2020;83(2):92-99. https://doi.org/10.26650/IUITFD.2019.0090


ABNT

Bayramoğlu, Z.; Köker, O.; Kandemirli, S.G.; Adaletli, İ.; Eker Ömeroğlu, R. SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS. Journal of Istanbul Faculty of Medicine, [Publisher Location], v. 83, n. 2, p. 92-99, 2020.


Chicago: Author-Date Style

Bayramoğlu, Zuhal, and Oya Köker and Sedat Giray Kandemirli and İbrahim Adaletli and Rukiye Eker Ömeroğlu. 2020. “SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS.” Journal of Istanbul Faculty of Medicine 83, no. 2: 92-99. https://doi.org/10.26650/IUITFD.2019.0090


Chicago: Humanities Style

Bayramoğlu, Zuhal, and Oya Köker and Sedat Giray Kandemirli and İbrahim Adaletli and Rukiye Eker Ömeroğlu. “SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS.” Journal of Istanbul Faculty of Medicine 83, no. 2 (Apr. 2024): 92-99. https://doi.org/10.26650/IUITFD.2019.0090


Harvard: Australian Style

Bayramoğlu, Z & Köker, O & Kandemirli, SG & Adaletli, İ & Eker Ömeroğlu, R 2020, 'SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS', Journal of Istanbul Faculty of Medicine, vol. 83, no. 2, pp. 92-99, viewed 26 Apr. 2024, https://doi.org/10.26650/IUITFD.2019.0090


Harvard: Author-Date Style

Bayramoğlu, Z. and Köker, O. and Kandemirli, S.G. and Adaletli, İ. and Eker Ömeroğlu, R. (2020) ‘SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS’, Journal of Istanbul Faculty of Medicine, 83(2), pp. 92-99. https://doi.org/10.26650/IUITFD.2019.0090 (26 Apr. 2024).


MLA

Bayramoğlu, Zuhal, and Oya Köker and Sedat Giray Kandemirli and İbrahim Adaletli and Rukiye Eker Ömeroğlu. “SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS.” Journal of Istanbul Faculty of Medicine, vol. 83, no. 2, 2020, pp. 92-99. [Database Container], https://doi.org/10.26650/IUITFD.2019.0090


Vancouver

Bayramoğlu Z, Köker O, Kandemirli SG, Adaletli İ, Eker Ömeroğlu R. SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS. Journal of Istanbul Faculty of Medicine [Internet]. 26 Apr. 2024 [cited 26 Apr. 2024];83(2):92-99. Available from: https://doi.org/10.26650/IUITFD.2019.0090 doi: 10.26650/IUITFD.2019.0090


ISNAD

Bayramoğlu, Zuhal - Köker, Oya - Kandemirli, SedatGiray - Adaletli, İbrahim - Eker Ömeroğlu, Rukiye. “SHEAR WAVE ELASTOGRAPHY OF SALIVARY AND THYROID GLANDS IN PEDIATRIC PATIENTS WITH FMF AND AMYLOIDOSIS”. Journal of Istanbul Faculty of Medicine 83/2 (Apr. 2024): 92-99. https://doi.org/10.26650/IUITFD.2019.0090



TIMELINE


Submitted31.10.2019
Accepted16.12.2019
Published Online24.03.2020

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