Sağlık Bilimlerinde İleri Araştırmalar Dergisi

GÖNDERBİLGİ
EnglishTürkçe

Araştırma Makalesi


DOI :10.26650/JARHS2020-748136   IUP :10.26650/JARHS2020-748136    Tam Metin (PDF)

A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology

Hüseyin Onur Tuncay, Miraç Ekici, Büşra Teke, Emine Akalın

Objective: Medicinal herbs are commonly used as complementary or prophylaxis in common illness, as well as in diseases such as cancer, where the disease is severe. In order to determine the use of plants and mushrooms among cancer patients, a survey was conducted with 100 cancer patients who are receiving treatment at polyclinics at the Istanbul University Institute of Oncology. Material and Methods: The questionnaires were conducted face to face with the patients and the results were evaluated in computer. Results: According to the survey results, only 24 of 100 patients were found to use the plants and mushrooms for treatment, to reduce the side effects of the treatment or to feel better. As a result, it was determined that a total of 17 different plants and 1 mushroom were used. The mechanism of action, side effects, and warnings of these plants and mushrooms on cancer treatment have been investigated. With this study, it was determined how the patients obtained the plants and mushrooms, how the age, gender or socioeconomic status affect the plants and mushrooms used and what kind of feedback the patients give about their experience. Conclusion: The fact that the plants and mushrooms are not supplied by pharmacies, the application of herbal treatments with the advice of people under the title "expert" and "reliable" cause many problems. The survey study yielded promising results about the use of plants and mushrooms by cancer patients in Turkey. Similar studies are expected to be conducted in more clinics. 

Anahtar Kelimeler: Survey, cancer, Istanbul University Institute of Oncology, medicinal plants, medicinal mushrooms
DOI :10.26650/JARHS2020-748136   IUP :10.26650/JARHS2020-748136    Tam Metin (PDF)

İstanbul Üniversitesi Onkoloji Enstitüsü’nde Hastalar Tarafından Kanser Tedavisinde Kullanılan Tıbbi Bitkiler ve Mantarlar Üzerine Bir Anket Çalışması

Hüseyin Onur Tuncay, Miraç Ekici, Büşra Teke, Emine Akalın

Amaç: Bitkiler ve mantarlar, tamamlayıcı veya koruyucu olarak basit hastalıklarda kullanıldığı gibi kanser gibi tedavisi ağır olan hastalıklarda da yaygın olarak kullanılmaktadır. Kanser hastaları arasında bitki ve mantar kullanımını belirlemek amacıyla İstanbul Üniversitesi Onkoloji Enstitüsü’nde polikliniklerde tedavi gören 100 kanser hastası ile bir anket çalışması yapılmıştır. Gereç ve Yöntem: Anketler hastalarla yüz yüze gerçekleştirilmiş ve sonuçlar bilgisayar ortamında değerlendirilmiştir. Bulgular: Anket sonuçlarına göre, 100 hastanın sadece 24’ünün bitki ve mantarları tedavi edici, tedavinin yan etkilerini azaltıcı veya daha iyi hissetmek için kullandığı saptanmıştır. Anket sonucunda toplam 17 farklı bitki ve 1 mantarın kullanıldığı tespit edilmiştir. Bu bitki ve mantarların kanser tedavisi üzerindeki etki mekanizması, yan etkileri ve uyarıları araştırılmıştır. Bu çalışma ile kanser hastalarının bitki ve mantarları nasıl temin ettikleri, yaş, cinsiyet veya sosyoekonomik durumun bitki ve mantar kullanımını nasıl etkilediği, kullanılan bitki veya mantardan yarar veya zarar nedeniyle ne tür geri bildirimler alındığı belirlenmiştir. Sonuç: Bitkilerin ve mantarların eczanelerden tedarik edilmemesi, "uzman" ve "güvenilir" başlığı altındaki kişilerin tavsiyesi ile bitkisel tedavilerin uygulanması birçok soruna neden olmaktadır. Yapılan anket çalışması, Türkiye'de kanser hastalarının bitki ve mantar kullanımına ilişkin fikir oluşturması açısından umut verici sonuçlar vermiştir. Gelecekte yapılacak benzer çalışmalar ile kanser tedavisi almakta olan hastaların bitki ve mantar kullanımlarının öğrenilmesi ve hastanın bir bütün olarak ele alınarak bu konuda eğitim almış uzmanların tavsiye vermeleri ümit edilmektedir.

Anahtar Kelimeler: Anket, kanser, İstanbul Üniversitesi Onkoloji Enstitüsü, tıbbi bitki, tıbbi mantar

PDF Görünüm

Referanslar

  • 1. Faydaoglu E, Sürücüoglu MS. History of the Use of Medical and Aromatic Plants and their Economic Importance Kastamonu Üniversitesi Orman Fakültesi Dergisi 2011;11(1): 52-67. google scholar
  • 2. Riddle MJ. Dioscorides on pharmacy and medicine. Austin: University of Texas Press; 1985. google scholar
  • 3. Engel LW, Straus SE. Development of therapeutics: opportunities within complementary and alternative medicine. Nat Rev Drug Discov 2002;1(3):229-37. google scholar
  • 4. Falzon CC, Balabanova A. Phytotherapy An Introduction to Herbal Medicine. Prim Care 2017;44(2):217-27. google scholar
  • 5. Fürst R, Zündorf I. Evidence-based phytotherapy in Europe: Where do we stand? Planta Med. 2015:81(12-13):962-7. google scholar
  • 6. Çetin O. The Use of Complementary and Alternative Medicine in Eskisehir. SosyoEkonomi 2007;6(6): 89-106. (article in Turkish with an abstract in English) google scholar
  • 7. Kav S, Hanoglu Z, Algıer L. Use of Complementary and Alternative Medicine by Cancer Patients in Turkey: A Literature Review. UHOD 2008;28(4):32-8. google scholar
  • 8. Başgöl Ş, Aslan E. Complementary and Alternative Medicines In Gynecologic Cancers: The Evidence-Based Approach. YBÜ Sağlık Bilimleri Fakültesi Hemşirelik E-Dergisi 2014;2(3):51-62. google scholar
  • 9. Yıldırım Y, Tinar S, Yorgun S, Toz E, Kaya B, Sonmez S, et al. The use of complementary and alternative medicine (CAM) therapies by Turkish women with gynecological cancer. Eur J Gynaecol Oncol 2006;27(1):81-5. google scholar
  • 10. Shukla M, Jaiswal S, Sharma A, Srivastava PK, Arya A, Dwivedi AK, et al. A combination of complexation and self-nanoemulsifying drug delivery system for enhancing oral bioavailability and anticancer efficacy of curcumin. Drug Dev Ind Pharm 2016;43(5):847-61. google scholar
  • 11. Nagpal M, Sood S. Role of curcumin in systemic and oral health: An overview. J Nat Sci Biol Med 2013;4(1):3-7. google scholar
  • 12. Fetrow CW, Avila JR, editors. Professional’s handbook of complementary and alternative medicine. Springhouse, PA: Springhouse; 1999. google scholar
  • 13. Mohammadi A, Mansoori B, Aghapour M, Baradaran B. Urtica dioica dichloromethane extract induce apoptosis from intrinsic pathway on human prostate cancer cells (PC3). Cell Mol Biol 2016;62(3):78-83. google scholar
  • 14. Chrubasik JE, Roufogalis BD, Wagner H, Chrubasik SA. A comprehensive review on nettle effect and efficacy profiles, Part I: Herba urticae. Phytomedicine 2007;14(6):423-35. google scholar
  • 15. World Health Organization. WHO Monographs on Selected Medicinal Plants Volume 2, World Health Organization. Geneva: World Health Organization; 2002. google scholar
  • 16. Ameri A. Ganoderic Acid in the Treatment of Prostate Cancer. Jundishapur J Nat Pharm Prod 2012;7(3):85-6. google scholar
  • 17. Wasser SP. Reishi or Ling Zhi (Ganoderma lucidum). Encyclopedia of Dietary Supplements 2005;1:603-2 google scholar
  • 18. Suganuma M, Saha A, Fujiki H. New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Sci 2011;102(2):317-23. google scholar
  • 19. Schönthal AH. Adverse effects of concentrated green tea extracts. Mol Nutr Food Res 2011;55(6):874–85. google scholar
  • 20. Braun L, Cohen M, editors. Herbs and Natural Supplements Volume 2: An Evidence-Based Guide. Australia: Elsevier Health Sciences; 2015. google scholar
  • 21. Vasanthi HR, Mukherjee S, Das DK. Potential health benefits of broccolichemico-biological overview. Mini-Rev Med Chem 2009;9(6):749-59. google scholar
  • 22. Kruger CL. Generally Recognized As Safe (Gras) otification for the Use of Aqueous Broccoli Seed Extract Powder in Food. U.S. Food Drug Administration. Office of Food Additive Safety: 2013 July. Report No: 496. google scholar
  • 23. El-Ashmawy NE, Khedr NF, El-Bahrawy HA, Abo Mansour HE. Ginger extract adjuvant to doxorubicin in mammary carcinoma: study of some molecular mechanisms. Eur J Nutr 2018;57(3):981-89. google scholar
  • 24. Altman RD, Marcussen KC. Effects of a Ginger Extract on Knee Pain in Patients with Osteoarthritis. Arthritis Rheum 2001;44(11):2531-8. google scholar
  • 25. Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins W, Rister RS, editors. German Commission E Monographs: Therapeutic Monographs on Medicinal Plants. Austin, Texas: American Botanical Council; 1998.p.135-136. google scholar
  • 26. Bourgou S, Bellila A, Falleh H, Ksouri R, Marzouk B. Phenolic composition and biological activities of Tunisian Nigella sativa L. shoots and roots. C R Biol 2008;331(1):48-55. google scholar
  • 27. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res 2003;17(4):299-305. google scholar
  • 28. El-Obeid A, Al-Harbi S, Al-Jomah N, Hassib A. Herbal melanin modulates tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) production. Phytomedicine 2006;13(5):324-33. google scholar
  • 29. Sung B, Chung HY, Kim N. Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy. J Cancer Prev 2016;21(4):216-26. google scholar
  • 30. Andres C, Chen WC, Darsow U, Mempel M, Ollert M, Ring J. Anaphylactic Reaction to Camomile Tea. Allergol Int 2009;58(1):135-6. google scholar
  • 31. Kijima I, Phung S, Hur G, Kwok SL, Chen S. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res 2006;66(11):5960-7. google scholar
  • 32. Miccadei S, Di venere D, Cardinali A, Romano F, Durazzo A, Foddai MS, et al. Antioxidative and apoptotic properties polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells. Nutr Cancer 2008;60(2):276-83. google scholar
  • 33. Englisch W, Beckers C, Unkauf M, Ruepp M, Zinserling V. Efficacy of Artichoke dry extract in patients with hyperlipoproteinemia. Arzneimittelforschung 2000;50(3):260-5. google scholar
  • 34. Lorusso G, Vannini N, Sogno I, Generoso L, Garbisa S, Noonan DM, et al. Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent. Eur J Cancer 2009;45(8):1474-84. google scholar
  • 35. Linde K, Knuppel L. Large-scale observational studies of hypericum extracts in patients with depressive disorders: a systematic review. Phytomedicine 2005;12(1–2):148-57. google scholar
  • 36. Jiménez S, Gascon S, Luquin A, Laguna M, Ancin-Azpilicueta C, Rodriguez-Yoldi MJ. Rosa canina extracts have antiproliferative and antioxidant effects on caco-2 human colon cancer. PloS one 2016;11(7):e0159136. google scholar
  • 37. Chrubasik E, Rougofalis BD, Müller-Ladner U, Chrubasik S. Systematic review on the Rosa canina effect and efficacy profiles. Phytother Res 2008;22(6):725-33. google scholar
  • 38. Merghoub N, Btaouri H, Benbacer L, Gmouh S, Trentesaux C, Brassart B, et al. Inula Viscosa Extracts Induces Telomere Shortening and Apoptosis in Cancer Cells and Overcome Drug Resistance. Nutr Cancer 2016;68(1):131-43. google scholar
  • 39. Zeggwagh NA, Quahidi ML, Lemhadri A, Eddouks M. Study of hypoglycaemic and hypolipidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats. J Ethnopharmacol 2006;108(2):223-7. google scholar
  • 40. Güneş H, Alper M, Çelikoğlu N. Anticancer effect of the fruit and seed extracts of Momordica charantia L. (Cucurbitaceae) on human cancer cell lines. Trop J Pharm Res 2019;18(10):2057-65. google scholar
  • 41. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health-Syst Pharm 2003;60(4):356-9. google scholar
  • 42. Sui JQ, Xie KP, Zou W, Xie MJ. Emodin inhibits breast cancer cell proliferation through the ERαMAPK/ Akt-cyclin D1/Bcl2 signaling pathway. Asian Pac J Cancer Prev 2014;15(15):6247-51. google scholar
  • 43. Malik MA, Bhat SA, Fatima B, Ahmad SB, Sidiqui S, Shrivastava P. Rheum emodi as valuable medicinal plant. IJGMP 2016;5(4):35-44. google scholar
  • 44. Mohammed FA, Elkady AI, Syed FQ, Mirza MB, Hakeem KR, Alkarim S. Anethum graveolens (dill) - A medicinal herb induces apoptosis and cell cycle arrest in HepG2 cell line. J Ethnopharmacol 2018;219:15–22. google scholar
  • 45. Kwon HK, Jeon WK, Hwang JS, Lee GG, So JS, Park JS, et al. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells. Cancer Lett 2009;278(2):174-82. google scholar
  • 46. Chevallier A. Encyclopedia of Herbal Medicine: 550 Herbs and Remedies for Common Ailments. Third ed. Dorling New York, USA: Kindersley Book; 2016. google scholar
  • 47. Zhu XX, Ding YH, Wu Y, Qian LY, Zou H, He Q. Silibinin: a potential old drug for cancer therapy. Expert Rev Clin Pharmacol 2016;9(10):1323-30. google scholar
  • 48. El-Kamary SS, Shardell MD, Adel-Hamid M, Ismail S, El-Ateek M, Metwally M, et al. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine 2009;16(5):391-400. google scholar
  • 49. Stewart BW, Wild CP. World Cancer Report. Lyon: IARC; 2014. google scholar
  • 50. NCI (National Cancer Institute) Age and Cancer Risk. serial online 2015 April (cited 2020 April 20) Available from: https://www.cancer.gov/ about-cancer/causes-prevention/risk/age google scholar

Atıflar

Biçimlendirilmiş bir atıfı kopyalayıp yapıştırın veya seçtiğiniz biçimde dışa aktarmak için seçeneklerden birini kullanın


DIŞA AKTAR



APA

Tuncay, H.O., Ekici, M., Teke, B., & Akalın, E. (2020). A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 3(2), 51-60. https://doi.org/10.26650/JARHS2020-748136


AMA

Tuncay H O, Ekici M, Teke B, Akalın E. A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology. Sağlık Bilimlerinde İleri Araştırmalar Dergisi. 2020;3(2):51-60. https://doi.org/10.26650/JARHS2020-748136


ABNT

Tuncay, H.O.; Ekici, M.; Teke, B.; Akalın, E. A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, [Publisher Location], v. 3, n. 2, p. 51-60, 2020.


Chicago: Author-Date Style

Tuncay, Hüseyin Onur, and Miraç Ekici and Büşra Teke and Emine Akalın. 2020. “A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 3, no. 2: 51-60. https://doi.org/10.26650/JARHS2020-748136


Chicago: Humanities Style

Tuncay, Hüseyin Onur, and Miraç Ekici and Büşra Teke and Emine Akalın. “A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 3, no. 2 (Dec. 2024): 51-60. https://doi.org/10.26650/JARHS2020-748136


Harvard: Australian Style

Tuncay, HO & Ekici, M & Teke, B & Akalın, E 2020, 'A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology', Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 3, no. 2, pp. 51-60, viewed 22 Dec. 2024, https://doi.org/10.26650/JARHS2020-748136


Harvard: Author-Date Style

Tuncay, H.O. and Ekici, M. and Teke, B. and Akalın, E. (2020) ‘A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology’, Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 3(2), pp. 51-60. https://doi.org/10.26650/JARHS2020-748136 (22 Dec. 2024).


MLA

Tuncay, Hüseyin Onur, and Miraç Ekici and Büşra Teke and Emine Akalın. “A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 3, no. 2, 2020, pp. 51-60. [Database Container], https://doi.org/10.26650/JARHS2020-748136


Vancouver

Tuncay HO, Ekici M, Teke B, Akalın E. A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology. Sağlık Bilimlerinde İleri Araştırmalar Dergisi [Internet]. 22 Dec. 2024 [cited 22 Dec. 2024];3(2):51-60. Available from: https://doi.org/10.26650/JARHS2020-748136 doi: 10.26650/JARHS2020-748136


ISNAD

Tuncay, HüseyinOnur - Ekici, Miraç - Teke, Büşra - Akalın, Emine. “A Survey Study on Medicinal Plants and Mushrooms Use in Treatment of Cancer by Patients at The Istanbul University Institute of Oncology”. Sağlık Bilimlerinde İleri Araştırmalar Dergisi 3/2 (Dec. 2024): 51-60. https://doi.org/10.26650/JARHS2020-748136



ZAMAN ÇİZELGESİ


Gönderim04.06.2020
Kabul24.06.2020
Çevrimiçi Yayınlanma10.07.2020

LİSANS


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


PAYLAŞ




İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.