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DOI :10.26650/B/ET07.2021.003.09   IUP :10.26650/B/ET07.2021.003.09    Full Text (PDF)

Integration of Immunogenetic and Bioinformatics Applications Into Medical Informatics

Fatma Savran OğuzSedat Karadeniz

T- and B-cells form the part of the adaptive or acquired immune system in vertebrates. These cells express an antigen receptor on their surface–the T-cell receptor (TCR) or B-cell receptor/Immunoglobulin (Ig)–which is responsible for the recognition of antigens. Major histocompatibility complex (MHC) are proteins that are found in all higher vertebrates in human beings. This complex is also called the human leucocytes antigen system. MHC class I and II molecules can be considered as peptide receptors, and the complex may be recognized by the T-cell receptor. MHC molecules not only present peptides to T cells but also are ligands for several natural killer cell receptors. Because of the abundant expression of MHC class I in many cells, the natural killer cells remain silent to the healthy tissue via the interactions with these receptors. Because of the introduction of novel techniques, immunogenetics, like other life sciences, is enjoying a very data-rich era and the novel high-throughput data allow us to study complex entities of the immune system. However, a proper study of these entities calls for an interdisciplinary approach in which bioinformaticians and computational biologists work in a close collaboration with immunologists. The correctly conduct of these studies along with the interpretation of the results requires an interdisciplinary approach in which bioinformatists and computational biologists work closely with immunologists.


DOI :10.26650/B/ET07.2021.003.09   IUP :10.26650/B/ET07.2021.003.09    Full Text (PDF)

İmmünogenetik ve Biyoenformatik Uygulamalarının Tıp Bilişimine Entegrasyonu

Fatma Savran OğuzSedat Karadeniz

T ve B hücreleri, omurgalılarda adaptif veya edinilmiş bağışıklık sisteminin bir parçasıdır. Bu hücreler, yüzeylerinde bir antijen reseptörü, antijenlerin tanınmasından sorumlu T hücresi reseptörü (TCR) veya B hücresi reseptörü/ İmmünoglobulin (Ig) eksprese eder. Büyük doku uyum kompleksi (MHC) proteinleri tüm yüksek omurgalılarda bulunur İnsanlarda bu komplekse insan lökosit antijen (HLA) sistemi adı verilmiştir. MHC sınıf I ve II molekülleri peptit reseptörleri olarak kabul edilebilir ve bu kompleks, T hücresi reseptörü tarafından tanınabilir. MHC molekülleri sadece T hücrelerine peptitler sunmakla kalmaz, aynı zamanda birkaç doğal öldürücü hücre (NK) reseptörü için de ligand olarak görev yaparlar . MHC-I’in birçok hücrede çok fazla ekspresyonu nedeniyle, NK hücreleri bu reseptörlerle etkileşimler yoluyla sağlıklı dokuya karşı sessiz kalır. Yeni tekniklerin sayesinde, diğer yaşam bilimleri gibi immünogenetik, veri açısından zengin bir dönemine girmiştir.Yeni yüksek verimlilikteki veriler, bağışıklık sisteminin karmaşık yapılarını incelememizi sağlar. Bununla birlikte, bunu doğru bir şekilde yapmak, biyoinformatistlerin ve hesaplamalı biyologların immünologlarla yakın işbirliği içinde çalıştığı disiplinler arası bir yaklaşımı gerektirir.



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