Research Article


DOI :10.26650/EurJBiol.2023.1298202   IUP :10.26650/EurJBiol.2023.1298202    Full Text (PDF)

Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh

Sanjeda TamannaRocky SheikhTaslimul JannatLaila Noor Islam

Objective: Oxidative stress (OS) has been linked to the development and progression of diabetes mellitus (DM). Although maintaining the redox status of protein is crucial for proper cellular function, proteins are likely to be damaged by OS. Therefore, the present study aimed to evaluate oxidative protein damage (OPD) in patients with DM.

Materials and Methods: A total of 160 participants were recruited, of whom 16 were patients with type 1 DM (T1DM), 84 were patients with type 2 DM (T2DM), and 60 were healthy control subjects. The activities of NADPH oxidase (NOX) and myeloperoxidase (MPO); total oxidative stress (TOS), ferric reducing ability of plasma (FRAP), oxidative stress index (OSI); serum albumin; OPD markers-total thiols (T-SH), protein carbonyls (PCO), and advanced oxidation protein products (AOPP) were assessed.

Results: The activities of serum NOX and MPO were significantly higher in both DM groups compared to controls. Significantly higher TOS and OSI and lower FRAP values were observed in both DM groups than in controls (p<0.001, for all). In patients, the levels of albumin and T-SH were significantly lower, but PCO was significantly elevated, while AOPP was higher in T1DM and significantly elevated in T2DM compared to controls. Correlation analyses between these parameters linked hyperglycemia with enhanced NOX, MPO and AOPP, and decreased FRAP and T-SH in diabetic patients. Further, significant correlations of albumin with T-SH and AOPP suggested an association of OS with hypoalbuminemia.

Conclusion: These findings highlight that hyperglycemia induces enhanced OS and consequent protein damage in both T1DM and T2DM patients.


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APA

Tamanna, S., Sheikh, R., Jannat, T., & Islam, L.N. (2023). Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh. European Journal of Biology, 82(1), 23-30. https://doi.org/10.26650/EurJBiol.2023.1298202


AMA

Tamanna S, Sheikh R, Jannat T, Islam L N. Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh. European Journal of Biology. 2023;82(1):23-30. https://doi.org/10.26650/EurJBiol.2023.1298202


ABNT

Tamanna, S.; Sheikh, R.; Jannat, T.; Islam, L.N. Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh. European Journal of Biology, [Publisher Location], v. 82, n. 1, p. 23-30, 2023.


Chicago: Author-Date Style

Tamanna, Sanjeda, and Rocky Sheikh and Taslimul Jannat and Laila Noor Islam. 2023. “Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh.” European Journal of Biology 82, no. 1: 23-30. https://doi.org/10.26650/EurJBiol.2023.1298202


Chicago: Humanities Style

Tamanna, Sanjeda, and Rocky Sheikh and Taslimul Jannat and Laila Noor Islam. Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh.” European Journal of Biology 82, no. 1 (Jul. 2024): 23-30. https://doi.org/10.26650/EurJBiol.2023.1298202


Harvard: Australian Style

Tamanna, S & Sheikh, R & Jannat, T & Islam, LN 2023, 'Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh', European Journal of Biology, vol. 82, no. 1, pp. 23-30, viewed 20 Jul. 2024, https://doi.org/10.26650/EurJBiol.2023.1298202


Harvard: Author-Date Style

Tamanna, S. and Sheikh, R. and Jannat, T. and Islam, L.N. (2023) ‘Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh’, European Journal of Biology, 82(1), pp. 23-30. https://doi.org/10.26650/EurJBiol.2023.1298202 (20 Jul. 2024).


MLA

Tamanna, Sanjeda, and Rocky Sheikh and Taslimul Jannat and Laila Noor Islam. Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh.” European Journal of Biology, vol. 82, no. 1, 2023, pp. 23-30. [Database Container], https://doi.org/10.26650/EurJBiol.2023.1298202


Vancouver

Tamanna S, Sheikh R, Jannat T, Islam LN. Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh. European Journal of Biology [Internet]. 20 Jul. 2024 [cited 20 Jul. 2024];82(1):23-30. Available from: https://doi.org/10.26650/EurJBiol.2023.1298202 doi: 10.26650/EurJBiol.2023.1298202


ISNAD

Tamanna, Sanjeda - Sheikh, Rocky - Jannat, Taslimul - Islam, LailaNoor. Evaluation of Oxidative Protein Damage in Patients with Type 1 and 2 Diabetes Mellitus in Bangladesh”. European Journal of Biology 82/1 (Jul. 2024): 23-30. https://doi.org/10.26650/EurJBiol.2023.1298202



TIMELINE


Submitted17.05.2023
Accepted07.06.2023
Published Online26.06.2023

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