Research Article


DOI :10.26650/EurJBiol.2024.1330850   IUP :10.26650/EurJBiol.2024.1330850    Full Text (PDF)

Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD

Ersan AtahanBuket Çalışkaner ÖztürkSuat SarıbaşBülent Tutluoğlu

Objective: Chronic obstructive pulmonary disease (COPD) is described as partially reversible airflow limitation. P-glycoprotein (P-gp/MDR1), encoded by the Multidrug Resistance 1 (MDR1) gene, is regarded as a protective component for the respiratory tract and is present in tracheobronchial epithelium and lung parenchyma, and removes particles from cells and protects against various xenobiotics. Polymorphisms of MDR1 gene and the alteration in the expression of P-gp are considered to have a negative effect on the severity of COPD pathogenesis and treatment efficacy. We aimed to investigate the relationship of the MDR1 gene polymorphisms with reversibility in COPD patients.

Materials and Methods: The MDR1 polymorphisms, specifically the 3435C>T and 2677A/G variations, were analyzed in 90 COPD patients.

Results: 15 of the 90 COPD patients had positive reversibility tests. 2677TT (p=0.044) and 3435TT (p=0.003) alleles related to positive reversibility tests. There were no significant differences in the distribution of the MDR1 C3435 alleles and the G2677 alleles (p> 0.05).

Conclusion: COPD patients with the TT allele have a higher rate of early reversibility positivity; this suggests that those carrying the allele may respond better to bronchodilator therapy. These markers could help to distinguish COPD patients who respond better to β2-agonists or who may not benefit much and, therefore, need different drugs.

Keywords: COPDMDR1polymorphism

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APA

Atahan, E., Çalışkaner Öztürk, B., Sarıbaş, S., & Tutluoğlu, B. (2024). Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD. European Journal of Biology, 83(1), 28-33. https://doi.org/10.26650/EurJBiol.2024.1330850


AMA

Atahan E, Çalışkaner Öztürk B, Sarıbaş S, Tutluoğlu B. Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD. European Journal of Biology. 2024;83(1):28-33. https://doi.org/10.26650/EurJBiol.2024.1330850


ABNT

Atahan, E.; Çalışkaner Öztürk, B.; Sarıbaş, S.; Tutluoğlu, B. Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD. European Journal of Biology, [Publisher Location], v. 83, n. 1, p. 28-33, 2024.


Chicago: Author-Date Style

Atahan, Ersan, and Buket Çalışkaner Öztürk and Suat Sarıbaş and Bülent Tutluoğlu. 2024. “Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD.” European Journal of Biology 83, no. 1: 28-33. https://doi.org/10.26650/EurJBiol.2024.1330850


Chicago: Humanities Style

Atahan, Ersan, and Buket Çalışkaner Öztürk and Suat Sarıbaş and Bülent Tutluoğlu. Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD.” European Journal of Biology 83, no. 1 (Oct. 2024): 28-33. https://doi.org/10.26650/EurJBiol.2024.1330850


Harvard: Australian Style

Atahan, E & Çalışkaner Öztürk, B & Sarıbaş, S & Tutluoğlu, B 2024, 'Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD', European Journal of Biology, vol. 83, no. 1, pp. 28-33, viewed 11 Oct. 2024, https://doi.org/10.26650/EurJBiol.2024.1330850


Harvard: Author-Date Style

Atahan, E. and Çalışkaner Öztürk, B. and Sarıbaş, S. and Tutluoğlu, B. (2024) ‘Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD’, European Journal of Biology, 83(1), pp. 28-33. https://doi.org/10.26650/EurJBiol.2024.1330850 (11 Oct. 2024).


MLA

Atahan, Ersan, and Buket Çalışkaner Öztürk and Suat Sarıbaş and Bülent Tutluoğlu. Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD.” European Journal of Biology, vol. 83, no. 1, 2024, pp. 28-33. [Database Container], https://doi.org/10.26650/EurJBiol.2024.1330850


Vancouver

Atahan E, Çalışkaner Öztürk B, Sarıbaş S, Tutluoğlu B. Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD. European Journal of Biology [Internet]. 11 Oct. 2024 [cited 11 Oct. 2024];83(1):28-33. Available from: https://doi.org/10.26650/EurJBiol.2024.1330850 doi: 10.26650/EurJBiol.2024.1330850


ISNAD

Atahan, Ersan - Çalışkaner Öztürk, Buket - Sarıbaş, Suat - Tutluoğlu, Bülent. Investigation of the Relationship between the Multidrug Resistance 1 Gene Polymorphisms and Bronchodilator Response in COPD”. European Journal of Biology 83/1 (Oct. 2024): 28-33. https://doi.org/10.26650/EurJBiol.2024.1330850



TIMELINE


Submitted21.07.2023
Accepted09.12.2023
Published Online23.02.2024

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