An in silico Investigation of Anticancer Peptide  Candidates in Fermented Food Microbiomes

Arıkan Muzaffer

doi:https://dx.doi.org/10.26650/experimed.1262138

Research Article

DOI :10.26650/experimed.1262138 IUP :10.26650/experimed.1262138 Full Text (PDF)

An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes

Objective: Cancer is a leading cause of death worldwide, requires development of new effective, specific, and safe strategies that do not carry the disadvantages of traditional cancer treatment approaches. Hence, this study aimed to identify anticancer peptide candidates in fermented food microbiomes through an in silico investigation. Materials and Methods: One hundred eight shotgun metagenomic sequencing samples from six studies on fermented food microbiomes were downloaded from the NCBI and ENA databases and included in the study. Bioinformatic analyses including quality control of raw data, de novo assembly, prediction of protein sequences, anticancer peptide predictions by an integrated use of four different prediction tools, toxicity predictions and database comparisons were performed. Results: One hundred forty-two novel anticancer peptide candidates were identified. Liquor, coffee, kefir fermentation samples contained the greatest numbers of anticancer peptide candidates while sugar, dairy, coconut kefir and brine-type fermentations were dominant sources according to the substrate type. Conclusion: This study indicates the potential of fermented food microbiomes as a useful source for candidate anticancer peptide detection. In vitro and in vivo validations of detected peptides may lead to development of new candidate molecules for cancer therapy in the future.

Keywords: Fermented food, microbiome, bioinformatics, metagenomics, anticancer peptide

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APA

Arıkan, M. (2023). An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes. Experimed, 13(1), 64-72. https://doi.org/10.26650/experimed.1262138

AMA

Arıkan M. An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes. Experimed. 2023;13(1):64-72. https://doi.org/10.26650/experimed.1262138

ABNT

Arıkan, M. An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes. Experimed, [Publisher Location], v. 13, n. 1, p. 64-72, 2023.

Chicago: Author-Date Style

Arıkan, Muzaffer,. 2023. “An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes.” Experimed 13, no. 1: 64-72. https://doi.org/10.26650/experimed.1262138

Chicago: Humanities Style

Arıkan, Muzaffer,. “An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes.” Experimed 13, no. 1 (Dec. 2023): 64-72. https://doi.org/10.26650/experimed.1262138

Harvard: Australian Style

Arıkan, M 2023, 'An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes', Experimed, vol. 13, no. 1, pp. 64-72, viewed 6 Dec. 2023, https://doi.org/10.26650/experimed.1262138

Harvard: Author-Date Style

Arıkan, M. (2023) ‘An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes’, Experimed, 13(1), pp. 64-72. https://doi.org/10.26650/experimed.1262138 (6 Dec. 2023).

MLA

Arıkan, Muzaffer,. “An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes.” Experimed, vol. 13, no. 1, 2023, pp. 64-72. [Database Container], https://doi.org/10.26650/experimed.1262138

Vancouver

Arıkan M. An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes. Experimed [Internet]. 6 Dec. 2023 [cited 6 Dec. 2023];13(1):64-72. Available from: https://doi.org/10.26650/experimed.1262138 doi: 10.26650/experimed.1262138

ISNAD

Arıkan, Muzaffer. “An in silico Investigation of Anticancer Peptide Candidates in Fermented Food Microbiomes”. Experimed 13/1 (Dec. 2023): 64-72. https://doi.org/10.26650/experimed.1262138

Volume 13, Issue 12023, P. 64-72

TIMELINE

Submitted	09.03.2023
Accepted	04.04.2023
Published Online	07.04.2023

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