Research Article


DOI :10.26650/experimed.1264306   IUP :10.26650/experimed.1264306    Full Text (PDF)

Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats

Mehmet Deniz YenerTuncay ÇolakSema Kurnaz ÖzbekSureyya CeylanEsra AcarHale Maral Kır

Objective: Unpredictable stress is a common factor that we encounter in our daily lives. In this context, we wanted to investigate the morphological effects of a chronic unpredictable mild stress (CUMS) model on rat hippocampus and serum levels of brain derived neurotrophic factor (BDNF) and glial fibrillary acidic protein (GFAP).

Materials and Methods: This study was carried out on 16 Wistar albino rat and divided into control and experiment groups. The CUMS model protocol was applied, and the morphological structures of the hippocampus were examined. The serum GFAP/BDNF levels were measured by ELISA method.

Results: The mean BDNF level was 1.65 ± 0.17 ng/mL in the control group and 2.25 ± 0.29 ng/mL in the CUMS group. The mean GFAP level was 3.04 ± 0.45 ng/mL in the control group and 2.96 ± 0.58 ng/mL in the CUMS group. When the polymorph cell layer (PCL) in gyrus dentatus was examined; the mean number of cells in the control group was 20 ± 1.38 for the left PCL and 17 ± 1.35 for the right PCL. In the stress group; the mean number of cells in the polymorph cell layer of gyrus dentatus was 27 ± 2.08 cells for the left side and 23 ± 2.01 for the right side.

Conclusions: As a result, morphological changes were observed in the gyrus dentatus region which has an important role in memory formation. The cells in the polymorph cell layer of gyrus dentatus underwent changes under stress.


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APA

Yener, M.D., Çolak, T., Özbek, S.K., Ceylan, S., Acar, E., & Kır, H.M. (2023). Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats. Experimed, 13(2), 73-79. https://doi.org/10.26650/experimed.1264306


AMA

Yener M D, Çolak T, Özbek S K, Ceylan S, Acar E, Kır H M. Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats. Experimed. 2023;13(2):73-79. https://doi.org/10.26650/experimed.1264306


ABNT

Yener, M.D.; Çolak, T.; Özbek, S.K.; Ceylan, S.; Acar, E.; Kır, H.M. Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats. Experimed, [Publisher Location], v. 13, n. 2, p. 73-79, 2023.


Chicago: Author-Date Style

Yener, Mehmet Deniz, and Tuncay Çolak and Sema Kurnaz Özbek and Sureyya Ceylan and Esra Acar and Hale Maral Kır. 2023. “Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats.” Experimed 13, no. 2: 73-79. https://doi.org/10.26650/experimed.1264306


Chicago: Humanities Style

Yener, Mehmet Deniz, and Tuncay Çolak and Sema Kurnaz Özbek and Sureyya Ceylan and Esra Acar and Hale Maral Kır. Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats.” Experimed 13, no. 2 (Sep. 2024): 73-79. https://doi.org/10.26650/experimed.1264306


Harvard: Australian Style

Yener, MD & Çolak, T & Özbek, SK & Ceylan, S & Acar, E & Kır, HM 2023, 'Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats', Experimed, vol. 13, no. 2, pp. 73-79, viewed 18 Sep. 2024, https://doi.org/10.26650/experimed.1264306


Harvard: Author-Date Style

Yener, M.D. and Çolak, T. and Özbek, S.K. and Ceylan, S. and Acar, E. and Kır, H.M. (2023) ‘Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats’, Experimed, 13(2), pp. 73-79. https://doi.org/10.26650/experimed.1264306 (18 Sep. 2024).


MLA

Yener, Mehmet Deniz, and Tuncay Çolak and Sema Kurnaz Özbek and Sureyya Ceylan and Esra Acar and Hale Maral Kır. Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats.” Experimed, vol. 13, no. 2, 2023, pp. 73-79. [Database Container], https://doi.org/10.26650/experimed.1264306


Vancouver

Yener MD, Çolak T, Özbek SK, Ceylan S, Acar E, Kır HM. Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats. Experimed [Internet]. 18 Sep. 2024 [cited 18 Sep. 2024];13(2):73-79. Available from: https://doi.org/10.26650/experimed.1264306 doi: 10.26650/experimed.1264306


ISNAD

Yener, MehmetDeniz - Çolak, Tuncay - Özbek, SemaKurnaz - Ceylan, Sureyya - Acar, Esra - Kır, HaleMaral. Effect of Chronic Unpredictable Mild Stress on Hippocampus and Serum Markers in Rats”. Experimed 13/2 (Sep. 2024): 73-79. https://doi.org/10.26650/experimed.1264306



TIMELINE


Submitted13.03.2023
Accepted14.06.2023
Published Online07.08.2023

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