Research Article


DOI :10.26650/experimed.2021.879204   IUP :10.26650/experimed.2021.879204    Full Text (PDF)

Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers

Onur ErtikÖzlem SaçanLevent KabasakalGöksel ŞenerRefiye Yanardağ

Objective: Diabetes mellitus is a metabolic disease of global importance. It affects many people by reducing their quality of life and even causing death. Therefore, research on diabetes mellitus maintains its popularity and continues to develop. Chard (Beta vulgaris L. var. cicla) is commonly used in diets and is known to have alternative hypoglycemic effects in diabetic individuals. This study investigated the protective effects of chard on glycoproteins (hexose, hexosamine, fucose and sialic acid) and the advanced oxidation protein product levels in diabetic rats’ livers. Materials and Methods: For this experiment, male Sprague–Dawley rats were separated into three groups: the control; Streptozotocin (STZ)-induced diabetic rats; and STZ-induced diabetic + chard extract. Fourteen days after diabetes induction, chard extract (2 g/kg/day, gavage) was administered for 45 days. On day 60, liver samples were collected, and 10% (w/v) homogenate was prepared for the analysis of glycoprotein components and advanced oxidation protein products. Results: Levels of glycoprotein parameters that include hexose, hexosamine, fucose, and sialic acid, as well as advanced oxidation protein product levels, increased in the diabetic group. Chard extract administration curatively reverted the altered biochemical parameters. Conclusion: From the results obtained, it can be suggested that chard extract has a protective effect on the diabetic livers of rats.

DOI :10.26650/experimed.2021.879204   IUP :10.26650/experimed.2021.879204    Full Text (PDF)

Diyabetik Sıçan Karaciğerinde Pazı Ekstresinin Glikoprotein Bileşikleri ve İleri Oksidasyon Protein Ürün Seviyeleri Üzerindeki Koruyucu Etkisi

Onur ErtikÖzlem SaçanLevent KabasakalGöksel ŞenerRefiye Yanardağ

Amaç: Diyabet, yaşam kalitesini düşüren ve hatta ölüme neden olan, tüm dünyada birçok insanı etkileyen metabolik bir hastalıktır. Bu yüzden diyabet üzerine yapılan araştırmalar popülerliğini korumakta ve gelişimini devam ettirmektedir. Pazı (Beta vulgaris L. var. cicla) Türkiye'de şeker hastalarının alternatif hipoglisemik ajan olarak kullandığı bir bitkidir. Bu çalışmada pazı ekstraktının, diyabetik sıçanların karaciğer dokusunda bulunan glikoproteinler (heksoz, heksozamin, fukoz ve siyalik asit) ve ileri oksidasyon protein ürün seviyeleri üzerindeki koruyucu etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Deneyde kullanılan erkek Sprague-Dawley sıçanları 3 gruba ayrıldı. Kontrol sıçanları; Streptozotosin (STZ) ile diyabetik yapılan sıçanlar; pazı ekstresi verilen STZ diyabetik sıçanlar; Sıçanların diyabet olmasından on dört gün sonra, sıçanlara pazı ekstresi (2 g/kg/gün, gavaj ile) belirtilen dozda 45 gün uygulandı. 60. günde sıçan karaciğerleri çıkarıldı ve glikoproteinler ve ileri oksidasyon protein ürünlerinin analizi için %10 (w/v) karaciğer homojenizatları hazırlandı. Bulgular: Yapılan deneyler sonucunda diyabetik sıçanların glikoprotein parametreleri olan heksoz, heksozamin, fukoz, siyalik asit ve ileri oksidasyon protein ürün seviyelerinin arttığı bulunmuştur. Pazı ekstresinin uygulaması, incelenen biyokimyasal parametre değerlerinin tersine çevirdiği belirlenmiştir. Sonuç: Elde edilen sonuçlardan pazı ektresinin diyabetik sıçanlar üzerinde koruyucu bir etkiye sahip olduğu ileri sürülebilir.


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APA

Ertik, O., Saçan, Ö., Kabasakal, L., Şener, G., & Yanardağ, R. (2021). Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. Experimed, 11(1), 27-32. https://doi.org/10.26650/experimed.2021.879204


AMA

Ertik O, Saçan Ö, Kabasakal L, Şener G, Yanardağ R. Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. Experimed. 2021;11(1):27-32. https://doi.org/10.26650/experimed.2021.879204


ABNT

Ertik, O.; Saçan, Ö.; Kabasakal, L.; Şener, G.; Yanardağ, R. Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. Experimed, [Publisher Location], v. 11, n. 1, p. 27-32, 2021.


Chicago: Author-Date Style

Ertik, Onur, and Özlem Saçan and Levent Kabasakal and Göksel Şener and Refiye Yanardağ. 2021. “Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers.” Experimed 11, no. 1: 27-32. https://doi.org/10.26650/experimed.2021.879204


Chicago: Humanities Style

Ertik, Onur, and Özlem Saçan and Levent Kabasakal and Göksel Şener and Refiye Yanardağ. Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers.” Experimed 11, no. 1 (Jul. 2021): 27-32. https://doi.org/10.26650/experimed.2021.879204


Harvard: Australian Style

Ertik, O & Saçan, Ö & Kabasakal, L & Şener, G & Yanardağ, R 2021, 'Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers', Experimed, vol. 11, no. 1, pp. 27-32, viewed 25 Jul. 2021, https://doi.org/10.26650/experimed.2021.879204


Harvard: Author-Date Style

Ertik, O. and Saçan, Ö. and Kabasakal, L. and Şener, G. and Yanardağ, R. (2021) ‘Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers’, Experimed, 11(1), pp. 27-32. https://doi.org/10.26650/experimed.2021.879204 (25 Jul. 2021).


MLA

Ertik, Onur, and Özlem Saçan and Levent Kabasakal and Göksel Şener and Refiye Yanardağ. Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers.” Experimed, vol. 11, no. 1, 2021, pp. 27-32. [Database Container], https://doi.org/10.26650/experimed.2021.879204


Vancouver

Ertik O, Saçan Ö, Kabasakal L, Şener G, Yanardağ R. Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers. Experimed [Internet]. 25 Jul. 2021 [cited 25 Jul. 2021];11(1):27-32. Available from: https://doi.org/10.26650/experimed.2021.879204 doi: 10.26650/experimed.2021.879204


ISNAD

Ertik, Onur - Saçan, Özlem - Kabasakal, Levent - Şener, Göksel - Yanardağ, Refiye. Protective Effect of Chard Extract on Glycoprotein Compounds and Advanced Oxidation Protein Product Levels in Diabetic Rat Livers”. Experimed 11/1 (Jul. 2021): 27-32. https://doi.org/10.26650/experimed.2021.879204



TIMELINE


Submitted12.02.2021
Accepted08.03.2021
Published Online27.04.2021

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