Research Article


DOI :10.26650/experimed.2021.933790   IUP :10.26650/experimed.2021.933790    Full Text (PDF)

Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma

Ayşegül Başak Akadam TekerErhan Teker

Amaç: Romatizmal kalp kapak hastalığının (RKKH)’da dahil olduğu çeşitli otoimmün ve kronik enflamatuvar hastalıklarda, IL-1 reseptör antagonisti (IL-1Ra) A2 allelinin uzun süreli ve şiddetli proenflamatuvar bağışıklık cevabıyla ilişkili olabileceği yönünde çalışmalar bulunmaktadır. Ancak, RKKH patogenezinde IL-1Ra varyantının ilişkisi ile ilgili çalışmalar oldukça sınırlıdır. Bu çalışmanın amacı, Türk hastalarda IL-1Ra rs2234663 değişken sayıda ardışık yineleme (VNTR) varyantları ile RKKH duyarlılığı ve/veya hastalığın şiddeti arasında bir ilişki olup olmadığını araştırmaktır. Gereç ve Yöntem: Bu vaka-kontrol çalışmasında (165 RKKH/300 kontrol) IL-1Ra VNTR için polimeraz zincir reaksiyonu (PZR) yöntemi ile genotipleme yapılmıştır. Bulgular: Hastalar ve kontroller arasında genotip ve allel frekanslarında istatistiksel olarak anlamlı fark tespit edilmiştir (p<0,001). A1 allel frekansı, RKKH hastalarında kontrol grubuyla karşılaştırıldığında, anlamlı olarak daha yüksek bulunmuştur (p= 0,004; OR= 3,821; %95 GA= 1,459-10,005). A3 allel frekansı hasta grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı şekilde artış göstermiştir (p= 0,034; OR= 2,536; %95 GA= 1,045-6,152). Şiddetli ve hafif kapak hasarı olan hastalar arasında genotip dağılımları istatistiksel olarak anlamlı şekilde farklı bulunmuştur (p= 0,031). A2 alleli şiddetli kapak hasarı olan hastalarda hafif kapak hasarı olan hastalara göre istatistiksel olarak yüksek olarak tespit edilmiştir (p= 0,003). Sonuç: IL-1Ra VNTR rs2234663 varyantlarının Türk toplumunda RKKH açısından duyarlı bireylerin tanımlanmasında kullanılabilecek uygun bir biyobelirteç olabileceği önerilmektedir.

DOI :10.26650/experimed.2021.933790   IUP :10.26650/experimed.2021.933790    Full Text (PDF)

A Study on the Relationship of IL-1Ra VNTR Gene Polymorphism in Turkish Patients with Rheumatic Heart Disease

Ayşegül Başak Akadam TekerErhan Teker

Objective: There are studies that suggest that the IL-1 receptor antagonist (IL-1Ra) A2 allele may be associated with a long-term and severe proinflammatory immune response in various autoimmune and chronic inflammatory diseases, including rheumatic valvular heart disease (RVHD). However, studies on the relationship of the IL-1Ra variant in the pathogenesis of RVHD are very limited. The aim of this study was to investigate whether there is a relationship between IL-1Ra rs2234663 variable number tandem repeat (VNTR) variants and RVHD susceptibility and/or disease severity in Turkish patients. Materials and Methods: In this case-control study (165 RVHD/300 controls), we genotyped IL-1Ra VNTR using the polymerase chain reaction (PCR) method. Results: There was a statistically significant difference in genotype and allele frequencies between patients and controls (p< 0.001). The A1 allele frequency was found to be significantly higher in RVHD patients compared to the control group (p= 0.004; OR= 3.821; 95% CI= 1.459-10.005). The A3 allele showed a statistically significant increase in the patient group compared to the control group (p= 0.034; OR= 2.536; 95% CI= 1.045-6.152). Genotype distributions were statistically significantly different between patients with severe and mild valve damage (p= 0.031). The A2 allele was statistically higher in patients with severe valve damage compared to patients with mild valve damage (p= 0.003). Conclusion: IL-1Ra VNTR can be recommended as a suitable biomarker that can be used to identify susceptible individuals in terms of RVHD susceptibility in the Turkish population.


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APA

Akadam Teker, A.B., & Teker, E. (2020). Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma. Experimed, 0(0), -. https://doi.org/10.26650/experimed.2021.933790


AMA

Akadam Teker A B, Teker E. Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma. Experimed. 2020;0(0):-. https://doi.org/10.26650/experimed.2021.933790


ABNT

Akadam Teker, A.B.; Teker, E. Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma. Experimed, [Publisher Location], v. 0, n. 0, p. -, 2020.


Chicago: Author-Date Style

Akadam Teker, Ayşegül Başak, and Erhan Teker. 2020. “Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma.” Experimed 0, no. 0: -. https://doi.org/10.26650/experimed.2021.933790


Chicago: Humanities Style

Akadam Teker, Ayşegül Başak, and Erhan Teker. Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma.” Experimed 0, no. 0 (Sep. 2021): -. https://doi.org/10.26650/experimed.2021.933790


Harvard: Australian Style

Akadam Teker, AB & Teker, E 2020, 'Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma', Experimed, vol. 0, no. 0, pp. -, viewed 24 Sep. 2021, https://doi.org/10.26650/experimed.2021.933790


Harvard: Author-Date Style

Akadam Teker, A.B. and Teker, E. (2020) ‘Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma’, Experimed, 0(0), pp. -. https://doi.org/10.26650/experimed.2021.933790 (24 Sep. 2021).


MLA

Akadam Teker, Ayşegül Başak, and Erhan Teker. Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma.” Experimed, vol. 0, no. 0, 2020, pp. -. [Database Container], https://doi.org/10.26650/experimed.2021.933790


Vancouver

Akadam Teker AB, Teker E. Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma. Experimed [Internet]. 24 Sep. 2021 [cited 24 Sep. 2021];0(0):-. Available from: https://doi.org/10.26650/experimed.2021.933790 doi: 10.26650/experimed.2021.933790


ISNAD

Akadam Teker, AyşegülBaşak - Teker, Erhan. Romatizmal Kalp Kapak Hastalığı Olan Türk Hastalarda IL-1Ra VNTR Gen Polimorfizminin İlişkisi Üzerine Bir Çalışma”. Experimed 0/0 (Sep. 2021): -. https://doi.org/10.26650/experimed.2021.933790



TIMELINE


Submitted06.05.2021
Accepted01.06.2021
Published Online27.08.2021

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