Significance of USP7 in Predicting Prognosis of  Mammary Ductal Adenocarcinoma in the Turkish  Population

Aydemir Esra; Burukçu Derya; Vural Gürcan; Kıvılcım Taner; Şahin Fikrettin

doi:https://dx.doi.org/10.26650/experimed.1211125

Research Article

DOI :10.26650/experimed.1211125 IUP :10.26650/experimed.1211125 Full Text (PDF)

Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population

Esra Aydemir, Derya Burukçu, Gürcan Vural, Taner Kıvılcım, Fikrettin Şahin

Objective: Breast cancer has the highest incidence and mortality rate among women worldwide. This study aims to analyze ubiquitin specific protease 7 (USP7) levels in mammary ductal adenocarcinoma patients in the Turkish population, to identify whether there is a relationship between the levels of USP7 protein and bad prognosis, which is indicated by enlarged tumor size, younger age, and receiving neo-adjuvant treatment. Materials and Methods: In our study, we analyzed USP7 levels by immunohistochemistry (IHC) staining in 38 mammary adenocarcinoma cases in the Turkish population. Corelation analyses were performed to evaluate the distribution of the patients by their age, tumor size, Ki-67 levels, and the status of neo-adjuvant treatment by their USP7 levels. The IHC data concluded that the average age and tumor size are reversely proportional to the USP7 levels, insignificantly. The differences between the levels of USP7 and Ki-67 measurements were found to be statistically insignificant between the groups. Results: Women who received the neo-adjuvant therapy prior to the operation presented much lower amount of USP7 levels when compared to their non-treated counterparts. Conclusions: These findings highlighted that mammary ductal adenocarcinoma patients in the Turkish population present varying USP7 protein levels. Even though the levels of UPS7 are partially insignificant, the presence of USP7 protein might be a prognostic indicator in breast cancer patients in the Turkish population with a larger study set.

Keywords: Ubiquitination, USP7, mammary ductal adenocarcinoma, the Turkish population

References

1. Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, et al. Current and future burden of breast cancer: Global statistics for 2020 and 2040. The Breast. 2022; 66: 15-23. [CrossRef] google scholar
2. Ellington TD, Miller JW, Henley SJ, Wilson RJ, Wu M, Richardson LC. Trends in breast cancer incidence, by race, ethnicity, and age among women aged >20 years - United States, 1999-2018. MMWR Morb Mortal Wkly Rep 2022; 71(2): 43-7. [CrossRef] google scholar
3. Llewellyn A, Howard C, McCabe C. An exploration of the experiences of women treated with radiotherapy for breast cancer: Learning from recent and historical cohorts to identify enduring needs. Eur J Oncol Nurs 2019; 39; 47-54 [CrossRef] google scholar
4. Global Burden of Disease Cancer Collaboration; Fitzmaurice C, Akinyemiju TF, Al Lami FH, Alam T, Alizadeh-Navaei R, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017: A systematic analysis for the global burden of disease study. JAMA Oncol 2018; 4(11): 1553-68. google scholar
5. Al-Mahmood S, Sapiezynski J, Garbuzenko OB, Minko T. Metastatic and triple-negative breast cancer: challenges and treatment options. Drug Deliv Transl Res 2018; 8(5): 1483-507. [CrossRef] google scholar
6. Seçer İ. Spss ve Lisrel ile pratik veri analizi. 2. baskı. Ankara: Anı Yayıncılık; 2015. google scholar
7. Everett RD, Meredith M, Orr A, Cross A, Kathoria M, Parkinson J. A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J 1997; 16(7): 1519-30. [CrossRef] google scholar
8. Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 2002; 416(6881): 648-53. [CrossRef] google scholar
9. Li M, Brooks CL, Kon N, Gu W. A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell 2004; 13(6): 879-86. [CrossRef] google scholar
10. Lin Y-T, Lin J, Liu Y-E, Chen Y-C, Liu S-T, Hsu K-W, et al. USP7 induces chemoresistance in triple-negative breast cancer via deubiquitination and stabilization of ABCB1. Cells 2022; 11(20): 3294 [CrossRef] google scholar
11. He Y, Zhong Y, Wang Y, Mao X. Recent insights into USP7: Construct, pathophysiology, and inhibitors. GPD 2022; 1(2): 118. [CrossRef] google scholar
12. Zhang L, Wang H, Tian L, Li H. Expression of USP7 and MARCH7 Is correlated with poor prognosis in epithelial ovarian cancer. Tohoku J Exp Med 2016; 239(3): 165-75. [CrossRef] google scholar
13. Zhang M-J, Chen D-S, Li H, Liu W-W, Han G-Y, Han Y-F. Clinical significance of USP7 and EZH2 in predicting prognosis of laryngeal squamous cell carcinoma and their possible functional mechanism. Int J Clin Exp Pathol 2019; 12(6): 2184-94. google scholar
14. Assi HA, Khoury KE, Dbouk H, Khalil LE, Mouhieddine TH, El Saghir NS. Epidemiology and prognosis of breast cancer in young women. J Thorac Dis 2013; 5 Suppl 1(Suppl 1): S2-8. google scholar
15. Giovinazzi S, Morozov VM, Summers MK, Reinhold WC, Ishov AM. USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase. Cell Death Differ 2013; 20(5): 721-31. [CrossRef] google scholar
16. Cartel M, Mouchel P-L, Gotanègre M, David L, Bertoli S, Mansat-De Mas V, et al. Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy. Leukemia 2021; 35(2): 417-32. [CrossRef] google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format

EXPORT

APA

Aydemir, E., Burukçu, D., Vural, G., Kıvılcım, T., & Şahin, F. (2023). Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population. Experimed, 13(1), 21-25. https://doi.org/10.26650/experimed.1211125

AMA

Aydemir E, Burukçu D, Vural G, Kıvılcım T, Şahin F. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population. Experimed. 2023;13(1):21-25. https://doi.org/10.26650/experimed.1211125

ABNT

Aydemir, E.; Burukçu, D.; Vural, G.; Kıvılcım, T.; Şahin, F. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population. Experimed, [Publisher Location], v. 13, n. 1, p. 21-25, 2023.

Chicago: Author-Date Style

Aydemir, Esra, and Derya Burukçu and Gürcan Vural and Taner Kıvılcım and Fikrettin Şahin. 2023. “Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population.” Experimed 13, no. 1: 21-25. https://doi.org/10.26650/experimed.1211125

Chicago: Humanities Style

Aydemir, Esra, and Derya Burukçu and Gürcan Vural and Taner Kıvılcım and Fikrettin Şahin. “Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population.” Experimed 13, no. 1 (Dec. 2023): 21-25. https://doi.org/10.26650/experimed.1211125

Harvard: Australian Style

Aydemir, E & Burukçu, D & Vural, G & Kıvılcım, T & Şahin, F 2023, 'Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population', Experimed, vol. 13, no. 1, pp. 21-25, viewed 8 Dec. 2023, https://doi.org/10.26650/experimed.1211125

Harvard: Author-Date Style

Aydemir, E. and Burukçu, D. and Vural, G. and Kıvılcım, T. and Şahin, F. (2023) ‘Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population’, Experimed, 13(1), pp. 21-25. https://doi.org/10.26650/experimed.1211125 (8 Dec. 2023).

MLA

Aydemir, Esra, and Derya Burukçu and Gürcan Vural and Taner Kıvılcım and Fikrettin Şahin. “Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population.” Experimed, vol. 13, no. 1, 2023, pp. 21-25. [Database Container], https://doi.org/10.26650/experimed.1211125

Vancouver

Aydemir E, Burukçu D, Vural G, Kıvılcım T, Şahin F. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population. Experimed [Internet]. 8 Dec. 2023 [cited 8 Dec. 2023];13(1):21-25. Available from: https://doi.org/10.26650/experimed.1211125 doi: 10.26650/experimed.1211125

ISNAD

Aydemir, Esra - Burukçu, Derya - Vural, Gürcan - Kıvılcım, Taner - Şahin, Fikrettin. “Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population”. Experimed 13/1 (Dec. 2023): 21-25. https://doi.org/10.26650/experimed.1211125

Volume 13, Issue 12023, P. 21-25

TIMELINE

Submitted	28.11.2022
Accepted	13.03.2023
Published Online	06.04.2023

LICENCE

Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.

Experimed