Research Article


DOI :10.26650/IstanbulJPharm.2020.0021   IUP :10.26650/IstanbulJPharm.2020.0021    Full Text (PDF)

Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing

Gökçen Yaşayan

Background and Aims: The use of natural polymers as wound dressings is attracting more interest due to their favoured properties such as biodegradability and biocompatibility. With this background, chitosan films and chitosan/pectin polyelectrolyte complex films encapsulating silver sulfadiazine were fabricated as novel wound dressings. Methods: Films were fabricated, and the surface topography and the surface roughness of the films were characterised by atomic force microscopy. Swelling and hydrolytic degradation behaviours of the films were monitored, and surface chemistry analysis was carried out. Following drug release studies, release kinetics were studied to evaluate the films for drug delivery. Results: Results suggest that the characteristic crystalline structure of chitosan films disappears after complexation with pectin. Polyelectrolyte complex films were found to be more durable than chitosan films due to their improved resistance to hydrolytic degradation. No incompatibilities amongst formulation components were detected. In vitro drug release studies indicated a rapid release of the drug from chitosan films compared to polyelectrolyte complex films. Conclusion: The overall results suggest that chitosan/pectin polyelectrolyte complex films have improved properties in terms of durability compared to chitosan films. Both films could be a promising candidate for wound healing applications considering the specific needs of different types of wounds.


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APA

Yaşayan, G. (2020). Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing. İstanbul Journal of Pharmacy, 0(0), 16-20. https://doi.org/10.26650/IstanbulJPharm.2020.0021


AMA

Yaşayan G. Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing. İstanbul Journal of Pharmacy. 2020;0(0):16-20. https://doi.org/10.26650/IstanbulJPharm.2020.0021


ABNT

Yaşayan, G. Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing. İstanbul Journal of Pharmacy, [Publisher Location], v. 0, n. 0, p. 16-20, 2020.


Chicago: Author-Date Style

Yaşayan, Gökçen,. 2020. “Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing.” İstanbul Journal of Pharmacy 0, no. 0: 16-20. https://doi.org/10.26650/IstanbulJPharm.2020.0021


Chicago: Humanities Style

Yaşayan, Gökçen,. Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing.” İstanbul Journal of Pharmacy 0, no. 0 (Sep. 2021): 16-20. https://doi.org/10.26650/IstanbulJPharm.2020.0021


Harvard: Australian Style

Yaşayan, G 2020, 'Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing', İstanbul Journal of Pharmacy, vol. 0, no. 0, pp. 16-20, viewed 16 Sep. 2021, https://doi.org/10.26650/IstanbulJPharm.2020.0021


Harvard: Author-Date Style

Yaşayan, G. (2020) ‘Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing’, İstanbul Journal of Pharmacy, 0(0), pp. 16-20. https://doi.org/10.26650/IstanbulJPharm.2020.0021 (16 Sep. 2021).


MLA

Yaşayan, Gökçen,. Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing.” İstanbul Journal of Pharmacy, vol. 0, no. 0, 2020, pp. 16-20. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2020.0021


Vancouver

Yaşayan G. Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing. İstanbul Journal of Pharmacy [Internet]. 16 Sep. 2021 [cited 16 Sep. 2021];0(0):16-20. Available from: https://doi.org/10.26650/IstanbulJPharm.2020.0021 doi: 10.26650/IstanbulJPharm.2020.0021


ISNAD

Yaşayan, Gökçen. Chitosan films and chitosan/pectin polyelectrolyte complexes encapsulating silver sulfadiazine for wound healing”. İstanbul Journal of Pharmacy 0/0 (Sep. 2021): 16-20. https://doi.org/10.26650/IstanbulJPharm.2020.0021



TIMELINE


Submitted31.03.2020
Accepted26.05.2020
Published Online04.11.2020

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