Research Article


DOI :10.26650/IstanbulJPharm.2020.0058   IUP :10.26650/IstanbulJPharm.2020.0058    Full Text (PDF)

In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash

Mbang Nyong Femi OyewoOlutayo Ademola AdeleyeCaroline Olufunke BabalolaOlufemi Babatunde BanjoModupe Nofisat AdebowaleFlorence Olubola Odeleye

Background and Aims: Mouthwashes are oral home care product used to treat mouth infections and to maintain satisfactory oral hygiene. The use of effective mouthwash is a reasonable means to prevent dental caries and oro-dental infections. The aim of this study was to evaluate the antimicrobial potential of Distemonanthus benthamianus chewing stick extract formulated as a mouthwash against some microorganisms associated with oro-dental infections in comparison with two commercial brand mouthwashes. Methods: The chewing stick was extracted with methanol and used to formulate mouthwash. Phytochemical screening was done to test for the presence of secondary metabolites. Antimicrobial activity of the crude extract and the formulated mouthwash on Staphylococcus aureus, Streptococcus mutans and Candida albicans was evaluated. The physical characteristics, pH and the stability of the mouthwashes were determined. Results: The extract contains alkaloids, saponins flavonoids, steroids and tannins. The crude extract and the formulated mouthwashes showed significant difference in activity against the test microorganisms in the following order Candida albicans > Staphylococcus aureus > Streptococcus mutans. At high concentrations of the extract (0.3%W/V and 0.5%W/V) in formulations, antibacterial activities were significantly higher against Streptococcus mutans and Staphylococcus aureus when compared with the commercial brands. The pH of the mouthwashes ranged from 5.2 - 7.4. The stability of formulation F5 was maintained for 12 weeks. Conclusion: The use of Distemonanthus benthamianus chewing stick extract mouthwash is safer, cheaper, and more effective in preventing dental caries and oro-dental infections compared to the commercial brand mouthwashes.


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APA

Femi Oyewo, M.N., Adeleye, O.A., Babalola, C.O., Banjo, O.B., Adebowale, M.N., & Odeleye, F.O. (2021). In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. İstanbul Journal of Pharmacy, 51(1), 105-110. https://doi.org/10.26650/IstanbulJPharm.2020.0058


AMA

Femi Oyewo M N, Adeleye O A, Babalola C O, Banjo O B, Adebowale M N, Odeleye F O. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. İstanbul Journal of Pharmacy. 2021;51(1):105-110. https://doi.org/10.26650/IstanbulJPharm.2020.0058


ABNT

Femi Oyewo, M.N.; Adeleye, O.A.; Babalola, C.O.; Banjo, O.B.; Adebowale, M.N.; Odeleye, F.O. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. İstanbul Journal of Pharmacy, [Publisher Location], v. 51, n. 1, p. 105-110, 2021.


Chicago: Author-Date Style

Femi Oyewo, Mbang Nyong, and Olutayo Ademola Adeleye and Caroline Olufunke Babalola and Olufemi Babatunde Banjo and Modupe Nofisat Adebowale and Florence Olubola Odeleye. 2021. “In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash.” İstanbul Journal of Pharmacy 51, no. 1: 105-110. https://doi.org/10.26650/IstanbulJPharm.2020.0058


Chicago: Humanities Style

Femi Oyewo, Mbang Nyong, and Olutayo Ademola Adeleye and Caroline Olufunke Babalola and Olufemi Babatunde Banjo and Modupe Nofisat Adebowale and Florence Olubola Odeleye. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash.” İstanbul Journal of Pharmacy 51, no. 1 (Jul. 2024): 105-110. https://doi.org/10.26650/IstanbulJPharm.2020.0058


Harvard: Australian Style

Femi Oyewo, MN & Adeleye, OA & Babalola, CO & Banjo, OB & Adebowale, MN & Odeleye, FO 2021, 'In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash', İstanbul Journal of Pharmacy, vol. 51, no. 1, pp. 105-110, viewed 23 Jul. 2024, https://doi.org/10.26650/IstanbulJPharm.2020.0058


Harvard: Author-Date Style

Femi Oyewo, M.N. and Adeleye, O.A. and Babalola, C.O. and Banjo, O.B. and Adebowale, M.N. and Odeleye, F.O. (2021) ‘In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash’, İstanbul Journal of Pharmacy, 51(1), pp. 105-110. https://doi.org/10.26650/IstanbulJPharm.2020.0058 (23 Jul. 2024).


MLA

Femi Oyewo, Mbang Nyong, and Olutayo Ademola Adeleye and Caroline Olufunke Babalola and Olufemi Babatunde Banjo and Modupe Nofisat Adebowale and Florence Olubola Odeleye. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash.” İstanbul Journal of Pharmacy, vol. 51, no. 1, 2021, pp. 105-110. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2020.0058


Vancouver

Femi Oyewo MN, Adeleye OA, Babalola CO, Banjo OB, Adebowale MN, Odeleye FO. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash. İstanbul Journal of Pharmacy [Internet]. 23 Jul. 2024 [cited 23 Jul. 2024];51(1):105-110. Available from: https://doi.org/10.26650/IstanbulJPharm.2020.0058 doi: 10.26650/IstanbulJPharm.2020.0058


ISNAD

Femi Oyewo, MbangNyong - Adeleye, OlutayoAdemola - Babalola, CarolineOlufunke - Banjo, OlufemiBabatunde - Adebowale, ModupeNofisat - Odeleye, FlorenceOlubola. In vitro evaluation of antimicrobial activity of Distemonanthus benthamianus chewing stick extract mouthwash”. İstanbul Journal of Pharmacy 51/1 (Jul. 2024): 105-110. https://doi.org/10.26650/IstanbulJPharm.2020.0058



TIMELINE


Submitted14.06.2020
Accepted21.09.2020
Published Online30.04.2021

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