Research Article


DOI :10.26650/IstanbulJPharm.2020.0070   IUP :10.26650/IstanbulJPharm.2020.0070    Full Text (PDF)

Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

Sinem ŞahinBurcu MesutMeltem Ezgi DurgunEsher ÖzçelikYıldız Özsoy Erginer

Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.


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APA

Şahin, S., Mesut, B., Durgun, M.E., Özçelik, E., & Özsoy Erginer, Y. (2021). Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. İstanbul Journal of Pharmacy, 51(1), 26-34. https://doi.org/10.26650/IstanbulJPharm.2020.0070


AMA

Şahin S, Mesut B, Durgun M E, Özçelik E, Özsoy Erginer Y. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. İstanbul Journal of Pharmacy. 2021;51(1):26-34. https://doi.org/10.26650/IstanbulJPharm.2020.0070


ABNT

Şahin, S.; Mesut, B.; Durgun, M.E.; Özçelik, E.; Özsoy Erginer, Y. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. İstanbul Journal of Pharmacy, [Publisher Location], v. 51, n. 1, p. 26-34, 2021.


Chicago: Author-Date Style

Şahin, Sinem, and Burcu Mesut and Meltem Ezgi Durgun and Esher Özçelik and Yıldız Özsoy Erginer. 2021. “Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin.” İstanbul Journal of Pharmacy 51, no. 1: 26-34. https://doi.org/10.26650/IstanbulJPharm.2020.0070


Chicago: Humanities Style

Şahin, Sinem, and Burcu Mesut and Meltem Ezgi Durgun and Esher Özçelik and Yıldız Özsoy Erginer. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin.” İstanbul Journal of Pharmacy 51, no. 1 (Jun. 2021): 26-34. https://doi.org/10.26650/IstanbulJPharm.2020.0070


Harvard: Australian Style

Şahin, S & Mesut, B & Durgun, ME & Özçelik, E & Özsoy Erginer, Y 2021, 'Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin', İstanbul Journal of Pharmacy, vol. 51, no. 1, pp. 26-34, viewed 25 Jun. 2021, https://doi.org/10.26650/IstanbulJPharm.2020.0070


Harvard: Author-Date Style

Şahin, S. and Mesut, B. and Durgun, M.E. and Özçelik, E. and Özsoy Erginer, Y. (2021) ‘Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin’, İstanbul Journal of Pharmacy, 51(1), pp. 26-34. https://doi.org/10.26650/IstanbulJPharm.2020.0070 (25 Jun. 2021).


MLA

Şahin, Sinem, and Burcu Mesut and Meltem Ezgi Durgun and Esher Özçelik and Yıldız Özsoy Erginer. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin.” İstanbul Journal of Pharmacy, vol. 51, no. 1, 2021, pp. 26-34. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2020.0070


Vancouver

Şahin S, Mesut B, Durgun ME, Özçelik E, Özsoy Erginer Y. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin. İstanbul Journal of Pharmacy [Internet]. 25 Jun. 2021 [cited 25 Jun. 2021];51(1):26-34. Available from: https://doi.org/10.26650/IstanbulJPharm.2020.0070 doi: 10.26650/IstanbulJPharm.2020.0070


ISNAD

Şahin, Sinem - Mesut, Burcu - Durgun, MeltemEzgi - Özçelik, Esher - Özsoy Erginer, Yıldız. Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin”. İstanbul Journal of Pharmacy 51/1 (Jun. 2021): 26-34. https://doi.org/10.26650/IstanbulJPharm.2020.0070



TIMELINE


Submitted13.07.2020
Accepted14.10.2020
Published Online30.04.2021

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