Research Article


DOI :10.26650/IstanbulJPharm.2022.054   IUP :10.26650/IstanbulJPharm.2022.054    Full Text (PDF)

The practice of dividing tablets: An uncertain act

David Galvis ParejaClara Ines ManriqueDiego Rojas GualdronHeidy Contreras

Background and Aims: Tablets can be split by patients for a number of reasons, using various instruments. Tablets can be scored or unscored; if scored, they may be split into pieces, and in spite of guidelines to do so patients are still at risk of resultant drug dose fluctuations, or being exposed to toxic or subtherapeutic doses. The aim of this study was to investigate differences in weight between halves of tablets, split by different populations and with different devices. Methods: 3-factor full factorial design (3 runs) was used with participants: patients, caregivers, nurses, medical doctors, and pharmacists; instruments: scissors, tablet cutters, knives, hand; drugs: losartan, clonidine, metoprolol, and warfarin. The risk of unequal tablet splitting was estimated and analyzed for each factor and their interaction with linearized generalized models. Results: Differences in weight were found to be above 15% and 25% of the theoretical weight as in general, the highest weight variations after splitting were found in clonidine with patients using scissors. The overall risk of non-equal tablet splitting was 22.5% for deviations > 15% and for > 25%. Conclusion: In this study, no tablet was split into halves of equal weight; based on these findings, splitting tablets is a questionable practice.


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APA

Pareja, D.G., Manrique, C.I., Gualdron, D.R., & Contreras, H. (2022). The practice of dividing tablets: An uncertain act. İstanbul Journal of Pharmacy, 52(2), 143-147. https://doi.org/10.26650/IstanbulJPharm.2022.054


AMA

Pareja D G, Manrique C I, Gualdron D R, Contreras H. The practice of dividing tablets: An uncertain act. İstanbul Journal of Pharmacy. 2022;52(2):143-147. https://doi.org/10.26650/IstanbulJPharm.2022.054


ABNT

Pareja, D.G.; Manrique, C.I.; Gualdron, D.R.; Contreras, H. The practice of dividing tablets: An uncertain act. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 2, p. 143-147, 2022.


Chicago: Author-Date Style

Pareja, David Galvis, and Clara Ines Manrique and Diego Rojas Gualdron and Heidy Contreras. 2022. “The practice of dividing tablets: An uncertain act.” İstanbul Journal of Pharmacy 52, no. 2: 143-147. https://doi.org/10.26650/IstanbulJPharm.2022.054


Chicago: Humanities Style

Pareja, David Galvis, and Clara Ines Manrique and Diego Rojas Gualdron and Heidy Contreras. The practice of dividing tablets: An uncertain act.” İstanbul Journal of Pharmacy 52, no. 2 (Oct. 2022): 143-147. https://doi.org/10.26650/IstanbulJPharm.2022.054


Harvard: Australian Style

Pareja, DG & Manrique, CI & Gualdron, DR & Contreras, H 2022, 'The practice of dividing tablets: An uncertain act', İstanbul Journal of Pharmacy, vol. 52, no. 2, pp. 143-147, viewed 3 Oct. 2022, https://doi.org/10.26650/IstanbulJPharm.2022.054


Harvard: Author-Date Style

Pareja, D.G. and Manrique, C.I. and Gualdron, D.R. and Contreras, H. (2022) ‘The practice of dividing tablets: An uncertain act’, İstanbul Journal of Pharmacy, 52(2), pp. 143-147. https://doi.org/10.26650/IstanbulJPharm.2022.054 (3 Oct. 2022).


MLA

Pareja, David Galvis, and Clara Ines Manrique and Diego Rojas Gualdron and Heidy Contreras. The practice of dividing tablets: An uncertain act.” İstanbul Journal of Pharmacy, vol. 52, no. 2, 2022, pp. 143-147. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2022.054


Vancouver

Pareja DG, Manrique CI, Gualdron DR, Contreras H. The practice of dividing tablets: An uncertain act. İstanbul Journal of Pharmacy [Internet]. 3 Oct. 2022 [cited 3 Oct. 2022];52(2):143-147. Available from: https://doi.org/10.26650/IstanbulJPharm.2022.054 doi: 10.26650/IstanbulJPharm.2022.054


ISNAD

Pareja, DavidGalvis - Manrique, ClaraInes - Gualdron, DiegoRojas - Contreras, Heidy. The practice of dividing tablets: An uncertain act”. İstanbul Journal of Pharmacy 52/2 (Oct. 2022): 143-147. https://doi.org/10.26650/IstanbulJPharm.2022.054



TIMELINE


Submitted09.06.2020
Accepted10.12.2020
Published Online29.08.2022

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