Meeting Abstract


DOI :10.26650/JARHS2021-1145546   IUP :10.26650/JARHS2021-1145546    Full Text (PDF)

ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL

Mehmet Ali KoçdorYağmur KayaArzu YıldırımHilal Koçdor

Anaplastic thyroid cancer (ATC) is one of the deadliest human malignancies, with no effective treatment, survival limited to a few months. The disease is characterized by a high rate of metastasis and is resistant to almost all available cytotoxic. There is an urgent need for chemicals with an effective, low toxicity profile. Objective: In study, the antimetastatic property of tetrahydrocurcumin (THC), the active metabolite of Curcuma Longa, was compared with docetaxel and the presence of synergism in the combination of the two substances was investigated in vitro. Material and Method: IC25 and IC50 concentrations of THC and (DX) in CAL62 and 8505C cells were determined by modified MTT method we developed in our laboratory. These 2 concentrations were compared with the control in the treatment groups. Cell motility as an indicator of metastatic potential was evaluated by in-vitro wound healing method. Cellular cytotoxicity was evaluated by TAS-TOS analyses. Results: In the 8505C cell line, Total antioxidant status was observed in the DXB-CRC IC50/2 group with a significant statistical increase. THC significantly reduced the oxidative stress index in the highest combination group, especially in DXB. It was found that the combined dose prevented migration and invasion in CAL62 cells in the first hours. There was no difference in Total Oxidant level between the combination and control groups. It was observed that the most effective dose that significantly reduced the oxidative level was DX50. THC in ATK cells has antimetastatic potential close to Docetaxel; It was thought that docetaxel reduced oxidative stress.


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    APA

    Koçdor, M.A., Kaya, Y., Yıldırım, A., & Koçdor, H. (2022). ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL. Journal of Advanced Research in Health Sciences, 5(1), 61-61. https://doi.org/10.26650/JARHS2021-1145546


    AMA

    Koçdor M A, Kaya Y, Yıldırım A, Koçdor H. ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL. Journal of Advanced Research in Health Sciences. 2022;5(1):61-61. https://doi.org/10.26650/JARHS2021-1145546


    ABNT

    Koçdor, M.A.; Kaya, Y.; Yıldırım, A.; Koçdor, H. ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 61-61, 2022.


    Chicago: Author-Date Style

    Koçdor, Mehmet Ali, and Yağmur Kaya and Arzu Yıldırım and Hilal Koçdor. 2022. “ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL.” Journal of Advanced Research in Health Sciences 5, no. 1: 61-61. https://doi.org/10.26650/JARHS2021-1145546


    Chicago: Humanities Style

    Koçdor, Mehmet Ali, and Yağmur Kaya and Arzu Yıldırım and Hilal Koçdor. ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 61-61. https://doi.org/10.26650/JARHS2021-1145546


    Harvard: Australian Style

    Koçdor, MA & Kaya, Y & Yıldırım, A & Koçdor, H 2022, 'ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 61-61, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1145546


    Harvard: Author-Date Style

    Koçdor, M.A. and Kaya, Y. and Yıldırım, A. and Koçdor, H. (2022) ‘ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL’, Journal of Advanced Research in Health Sciences, 5(1), pp. 61-61. https://doi.org/10.26650/JARHS2021-1145546 (24 Feb. 2024).


    MLA

    Koçdor, Mehmet Ali, and Yağmur Kaya and Arzu Yıldırım and Hilal Koçdor. ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 61-61. [Database Container], https://doi.org/10.26650/JARHS2021-1145546


    Vancouver

    Koçdor MA, Kaya Y, Yıldırım A, Koçdor H. ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):61-61. Available from: https://doi.org/10.26650/JARHS2021-1145546 doi: 10.26650/JARHS2021-1145546


    ISNAD

    Koçdor, MehmetAli - Kaya, Yağmur - Yıldırım, Arzu - Koçdor, Hilal. ANTIMETASTATIC POTENTIAL OF CUCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 61-61. https://doi.org/10.26650/JARHS2021-1145546



    TIMELINE


    Published Online09.08.2022

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