Research Article


DOI :10.26650/JARHS2023-1199242   IUP :10.26650/JARHS2023-1199242    Full Text (PDF)

COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION

Derya BaykızZeynep Gizem DemirtakanElif Ayduk GövdeliSamim EmetAli Elitok

Objective: Coronary collateral circulation (CCC) plays a significant role in cardiovascular prognosis, and well-developed CCC improves survival. The aim of this study was to investigate whether the serum uric acid to highdensity lipoprotein cholesterol ratio (UA/HDL-C) is associated with coronary collateral development. Materials and Methods: This retrospective study enrolled 111 patients with stable coronary artery disease and at least one chronic total occlusion (CTO) at invasive coronary angiography. Blood samples were obtained from all patients before the angiography procedure. The collateral degree was determined according to the Rentrop scoring system. Patients were classified into a poor CCC group (Rentrop grades 0-1, n=47) or a good CCC group (Rentrop grades 2-3, n=64). The UA/HDL-C ratios were compared between the two groups. Results: The UA/HDL-C ratios were significantly higher in patients with poor CCC compared with the patients with good CCC (0.18 [0.06-0.49] vs 0.14 [0.05-0.31], respectively; p<0.001). In correlation analysis, the CCC was significantly negatively correlated with UA/HDL-C and UA levels (r=- 0.333, p<0.001; r=-0.502, p<0.001, respectively). According to the ROC analysis, a cut-off value of > 0.17 for the UA/HDL-C ratio predicted poor collateral development with 54.3% sensitivity and 79.3% specificity (AUC=0.711, 95% CI 0.617–0.794, p<0.001). In multivariate regression analysis, serum UA was found to be an independent predictor of poor collateral development (OR=2.818, p=0.022). Conclusion: The present study showed that although the UA/HDL-C ratio may be associated with poor collateral development, serum UA levels seem to be a better predictor of poor CCC than UA/HDL-C ratios in patients with CTO.

DOI :10.26650/JARHS2023-1199242   IUP :10.26650/JARHS2023-1199242    Full Text (PDF)

KRONİK TOTAL OKLÜZYONU OLAN HASTALARDA ÜRİK ASİT YÜKSEK YOĞUNLUKLU LİPOPROTEİN KOLESTEROL ORANI VE SERUM ÜRİK ASİT DÜZEYLERİNİN KORONER KOLLATERAL DOLAŞIM ÜZERİNDE KARŞILAŞTIRILMASI

Derya BaykızZeynep Gizem DemirtakanElif Ayduk GövdeliSamim EmetAli Elitok

Amaç: Koroner kollateral dolaşım (KKD) kardiyovasküler prognoz üzerinde önemli bir rol oynar ve iyi gelişmiş KKD surviyi iyileştirir. Bu çalışmanın amacı, serum ürik asit ve yüksek yoğunluklu lipoprotein kolesterol oranının (ÜA/HDL-K) koroner kollateral gelişimi ile ilişkili olup olmadığını araştırmaktır. Gereç ve Yöntem: Bu retrospektif çalışmaya stabil koroner arter hastalığı ve invaziv koroner anjiyografide en az bir kronik total oklüzyonu (KTO) olan 111 hasta dahil edildi. Anjiyografi işlemi öncesi tüm hastalardan kan örnekleri alındı. Kollateral derecesi Rentrop sınıflamasına göre belirlendi. Hastalar kötü KKD grubu (Rentrop derece 0-1, n=47) veya iyi KKD grubu (Rentrop derece 2-3, n=64) olarak sınıflandırıldı. ÜA/HDL-K oranları iki grup arasında karşılaştırıldı. Bulgular: ÜA/HDL-K oranları, kötü KKD’si olan hastalarda, iyi KKD’si olan hastalarla karşılaştırıldığında anlamlı olarak daha yüksekti (0,18 [0,06- 0,49] vs 0,14 [0,05-0,31], sırasıyla; p<0,001). Korelasyon analizinde, KKD, ÜA/HDL-K ve ÜA seviyeleri ile anlamlı bir negatif korelasyon gösterdi (r=- 0,333, p<0,001; r=-0,502, p<0,001, sırasıyla). ROC analizinde, ÜA/HDL-K oranı için > 0,17’lik bir kesme değeri, %54,3 duyarlılık ve %79,3 özgüllük ile zayıf kollateral gelişimini öngördü (AUC=0,711, 95% CI 0,617–0,794, p<0,001). Çok değişkenli regresyon analizinde, serum ÜA kötü kollateral gelişiminin bağımsız bir prediktörü olarak bulundu (OR=2,818, p=0,022). Sonuç: Bu çalışma göstermiştir ki, ÜA/HDL-K oranı zayıf kollateral gelişimi ile ilişkili olabilse de, serum ÜA seviyeleri, KTO’lu hastalarda ÜA/HDL-K oranlarından kötü KKD’nin daha iyi bir öngördürücüsü olarak görünmektedir


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APA

Baykız, D., Demirtakan, Z.G., Ayduk Gövdeli, E., Emet, S., & Elitok, A. (2023). COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Journal of Advanced Research in Health Sciences, 6(1), 1-9. https://doi.org/10.26650/JARHS2023-1199242


AMA

Baykız D, Demirtakan Z G, Ayduk Gövdeli E, Emet S, Elitok A. COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Journal of Advanced Research in Health Sciences. 2023;6(1):1-9. https://doi.org/10.26650/JARHS2023-1199242


ABNT

Baykız, D.; Demirtakan, Z.G.; Ayduk Gövdeli, E.; Emet, S.; Elitok, A. COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 6, n. 1, p. 1-9, 2023.


Chicago: Author-Date Style

Baykız, Derya, and Zeynep Gizem Demirtakan and Elif Ayduk Gövdeli and Samim Emet and Ali Elitok. 2023. “COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION.” Journal of Advanced Research in Health Sciences 6, no. 1: 1-9. https://doi.org/10.26650/JARHS2023-1199242


Chicago: Humanities Style

Baykız, Derya, and Zeynep Gizem Demirtakan and Elif Ayduk Gövdeli and Samim Emet and Ali Elitok. COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION.” Journal of Advanced Research in Health Sciences 6, no. 1 (Jul. 2024): 1-9. https://doi.org/10.26650/JARHS2023-1199242


Harvard: Australian Style

Baykız, D & Demirtakan, ZG & Ayduk Gövdeli, E & Emet, S & Elitok, A 2023, 'COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION', Journal of Advanced Research in Health Sciences, vol. 6, no. 1, pp. 1-9, viewed 18 Jul. 2024, https://doi.org/10.26650/JARHS2023-1199242


Harvard: Author-Date Style

Baykız, D. and Demirtakan, Z.G. and Ayduk Gövdeli, E. and Emet, S. and Elitok, A. (2023) ‘COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION’, Journal of Advanced Research in Health Sciences, 6(1), pp. 1-9. https://doi.org/10.26650/JARHS2023-1199242 (18 Jul. 2024).


MLA

Baykız, Derya, and Zeynep Gizem Demirtakan and Elif Ayduk Gövdeli and Samim Emet and Ali Elitok. COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION.” Journal of Advanced Research in Health Sciences, vol. 6, no. 1, 2023, pp. 1-9. [Database Container], https://doi.org/10.26650/JARHS2023-1199242


Vancouver

Baykız D, Demirtakan ZG, Ayduk Gövdeli E, Emet S, Elitok A. COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION. Journal of Advanced Research in Health Sciences [Internet]. 18 Jul. 2024 [cited 18 Jul. 2024];6(1):1-9. Available from: https://doi.org/10.26650/JARHS2023-1199242 doi: 10.26650/JARHS2023-1199242


ISNAD

Baykız, Derya - Demirtakan, ZeynepGizem - Ayduk Gövdeli, Elif - Emet, Samim - Elitok, Ali. COMPARISON OF URIC ASID HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO AND SERUM URIC ASID LEVELS ON CORONARY COLLETERAL CIRCULATION IN PATIENTS WITH CHRONIC TOTAL OCCLUSION”. Journal of Advanced Research in Health Sciences 6/1 (Jul. 2024): 1-9. https://doi.org/10.26650/JARHS2023-1199242



TIMELINE


Submitted04.11.2022
Accepted28.11.2022
Published Online09.02.2023

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