Meeting Abstract


DOI :10.26650/JARHS2021-1135830   IUP :10.26650/JARHS2021-1135830    Full Text (PDF)

DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER

Gizem Çalıbaşı Koçal

Diet influence human health in different ways. But it is well known that diet can adversely affect various human pathologies, like obesity, diabetes, hypertension, and cancer. The relationship between diet, obesity and cancer has been studied for different types of cancer such as breast, colorectal and gastric cancers. High fat diet induced obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, tumorigenesis is facilitated by a pro-obesity high-fat diet (HFD) by enhancing PPAR (peroxisome proliferator-activated receptor) nuclear receptor activation. PPARs induced fatty acid oxidation increased stem cell number and tumorigenesis. The rate controlling enzyme of fatty acid oxidation, CPT1A, dampens the pro-tumorigenic phenotype by blunting HFD effect in ISCs. High-fat ketogenic diet also elevates ISC function and regeneration capacity through βOHB-mediated Notch signaling, but a glucose-supplemented diet has the opposite effects. High glucose diet also presents an indirect link between sugar and cancer. The relationship dietary supplements used in addition to the diet and cancer is frequently studied. In literature, there is strong evidence on the anticancer effects of anthocyanins, curcumin, vitamin D, and their mechanisms.


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    APA

    Çalıbaşı Koçal, G. (2022). DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER. Journal of Advanced Research in Health Sciences, 5(1), 32-32. https://doi.org/10.26650/JARHS2021-1135830


    AMA

    Çalıbaşı Koçal G. DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER. Journal of Advanced Research in Health Sciences. 2022;5(1):32-32. https://doi.org/10.26650/JARHS2021-1135830


    ABNT

    Çalıbaşı Koçal, G. DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 32-32, 2022.


    Chicago: Author-Date Style

    Çalıbaşı Koçal, Gizem,. 2022. “DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER.” Journal of Advanced Research in Health Sciences 5, no. 1: 32-32. https://doi.org/10.26650/JARHS2021-1135830


    Chicago: Humanities Style

    Çalıbaşı Koçal, Gizem,. DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 32-32. https://doi.org/10.26650/JARHS2021-1135830


    Harvard: Australian Style

    Çalıbaşı Koçal, G 2022, 'DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 32-32, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1135830


    Harvard: Author-Date Style

    Çalıbaşı Koçal, G. (2022) ‘DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER’, Journal of Advanced Research in Health Sciences, 5(1), pp. 32-32. https://doi.org/10.26650/JARHS2021-1135830 (24 Feb. 2024).


    MLA

    Çalıbaşı Koçal, Gizem,. DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 32-32. [Database Container], https://doi.org/10.26650/JARHS2021-1135830


    Vancouver

    Çalıbaşı Koçal G. DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):32-32. Available from: https://doi.org/10.26650/JARHS2021-1135830 doi: 10.26650/JARHS2021-1135830


    ISNAD

    Çalıbaşı Koçal, Gizem. DIETARY-BASED MOLECULAR TARGETS AND THERAPEUTIC OPPORTUNITIES IN CANCER”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 32-32. https://doi.org/10.26650/JARHS2021-1135830



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    Published Online09.08.2022

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