Meeting Abstract


DOI :10.26650/JARHS2021-1145563   IUP :10.26650/JARHS2021-1145563    Full Text (PDF)

INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY

Tarık SalmanArzu YıldırımYağmur KayaHilal Koçdor

Objective: The aim of this study was to determine the effects of hexane extract prepared from Thymbra spicata (TS) on the cytotoxic, antioxidant and metastatic process in human breast adenocarcinoma cell lines (MDA-MB-231, BT-474) in combination with the chemotherapeutic drug Paclitaxel (PAC). Materials And Methods: IC25 and IC50 concentrations of TS and PAC in MDA-MB-231 and BT-474 cell lines were determined by the modified MTT method we developed in our laboratory. Cell motility as an indicator of metastatic potential was evaluated by in vitro wound healing method. MDA was evaluated in cellular cytotoxicity in MB 231 by TAS and TOS analyses. Results: IC25 and IC50 concentrations of TS and PAC in MDA MB 231 and BT-474 cell lines were determined by the modified MTT method we developed in our laboratory. Cell motility as an indicator of metastatic potential was evaluated by in vitro wound healing method. MDA was evaluated in cellular cytotoxicity in MB 231 by TAS and TOS analyses. In wound healing experiments where migration and invasion were tested: MDA MB 231; There was no statistically significant difference in the effect of PAC and TS25/PAC25 doses on cell migration. BT-474; TS and TS25/PAC25 doses were found to be effective in stopping cell migration. Conclusion: The findings revealed the prediction that TS may be among the candidate agents in terms of giving as supportive treatment.


PDF View

References

    Citations

    Copy and paste a formatted citation or use one of the options to export in your chosen format


    EXPORT



    APA

    Salman, T., Yıldırım, A., Kaya, Y., & Koçdor, H. (2022). INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY. Journal of Advanced Research in Health Sciences, 5(1), 62-62. https://doi.org/10.26650/JARHS2021-1145563


    AMA

    Salman T, Yıldırım A, Kaya Y, Koçdor H. INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY. Journal of Advanced Research in Health Sciences. 2022;5(1):62-62. https://doi.org/10.26650/JARHS2021-1145563


    ABNT

    Salman, T.; Yıldırım, A.; Kaya, Y.; Koçdor, H. INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 62-62, 2022.


    Chicago: Author-Date Style

    Salman, Tarık, and Arzu Yıldırım and Yağmur Kaya and Hilal Koçdor. 2022. “INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY.” Journal of Advanced Research in Health Sciences 5, no. 1: 62-62. https://doi.org/10.26650/JARHS2021-1145563


    Chicago: Humanities Style

    Salman, Tarık, and Arzu Yıldırım and Yağmur Kaya and Hilal Koçdor. INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 62-62. https://doi.org/10.26650/JARHS2021-1145563


    Harvard: Australian Style

    Salman, T & Yıldırım, A & Kaya, Y & Koçdor, H 2022, 'INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 62-62, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1145563


    Harvard: Author-Date Style

    Salman, T. and Yıldırım, A. and Kaya, Y. and Koçdor, H. (2022) ‘INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY’, Journal of Advanced Research in Health Sciences, 5(1), pp. 62-62. https://doi.org/10.26650/JARHS2021-1145563 (24 Feb. 2024).


    MLA

    Salman, Tarık, and Arzu Yıldırım and Yağmur Kaya and Hilal Koçdor. INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 62-62. [Database Container], https://doi.org/10.26650/JARHS2021-1145563


    Vancouver

    Salman T, Yıldırım A, Kaya Y, Koçdor H. INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):62-62. Available from: https://doi.org/10.26650/JARHS2021-1145563 doi: 10.26650/JARHS2021-1145563


    ISNAD

    Salman, Tarık - Yıldırım, Arzu - Kaya, Yağmur - Koçdor, Hilal. INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF T. SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDARD CHEMOTHERAPY”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 62-62. https://doi.org/10.26650/JARHS2021-1145563



    TIMELINE


    Published Online09.08.2022

    LICENCE


    Attribution-NonCommercial (CC BY-NC)

    This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


    SHARE




    Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.