Meeting Abstract


DOI :10.26650/JARHS2021-1136752   IUP :10.26650/JARHS2021-1136752    Full Text (PDF)

microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER

Milad AsadiAyşe CanerVenus ZafariAhmed Al OmarCan MüftüoğluTuoraj Asvadi Kermani

Objectives: Colorectal cancer (CRC)is a highly preventable and treatable disease when detected early. microRNAs (miRNAs) have the potential to serve as ideal noninvasive biomarkers. The aim of this study was to determine the diagnostic and prognostic biomarker potential of some miRNAs in serum samples of patients with CRC. Methods: 75 patients with CRC and 75 healthy individuals were enrolled in the study. Serum samples of the patients were obtained before and three months after surgery and once from healthy controls. The relative expression levels of miR-23, miR-223, miR-12469, and miR-150 in the serum of samples were determined using quantitative real-time PCR. The results were evaluated the receiver operating characteristic (ROC) curve analysis. Results: The expression level of mir-150 was significantly up-regulated in CRC compared to healthy group. The expression levels of miR-23 and miR-223 in serum were non-significantly up-regulated in CRC patients. But there were no changes in the expression level of miR-1246 in both groups. In addition, expression levels of miR-23 and miR-223 were significantly down-regulated three months after surgery, whereas miR-150 showed a significant level of up-regulation. However, there is no significant relationship between the serum levels of these genes and the clinical characteristics of CRC patients. By ROC curve analysis, only miR-23 and miR-150 were found to be able to distinguish CRC patients from controls with relatively high accuracy. Conclusions: Taken together, the expression levels of miR-23 and miR-150 in serum may be potential biomarker candidates for the diagnosis and prognosis of CRC.


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    APA

    Asadi, M., Caner, A., Zafari, V., Al Omar, A., Müftüoğlu, C., & Asvadi Kermani, T. (2022). microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER. Journal of Advanced Research in Health Sciences, 5(1), 53-53. https://doi.org/10.26650/JARHS2021-1136752


    AMA

    Asadi M, Caner A, Zafari V, Al Omar A, Müftüoğlu C, Asvadi Kermani T. microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER. Journal of Advanced Research in Health Sciences. 2022;5(1):53-53. https://doi.org/10.26650/JARHS2021-1136752


    ABNT

    Asadi, M.; Caner, A.; Zafari, V.; Al Omar, A.; Müftüoğlu, C.; Asvadi Kermani, T. microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 53-53, 2022.


    Chicago: Author-Date Style

    Asadi, Milad, and Ayşe Caner and Venus Zafari and Ahmed Al Omar and Can Müftüoğlu and Tuoraj Asvadi Kermani. 2022. “microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER.” Journal of Advanced Research in Health Sciences 5, no. 1: 53-53. https://doi.org/10.26650/JARHS2021-1136752


    Chicago: Humanities Style

    Asadi, Milad, and Ayşe Caner and Venus Zafari and Ahmed Al Omar and Can Müftüoğlu and Tuoraj Asvadi Kermani. microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 53-53. https://doi.org/10.26650/JARHS2021-1136752


    Harvard: Australian Style

    Asadi, M & Caner, A & Zafari, V & Al Omar, A & Müftüoğlu, C & Asvadi Kermani, T 2022, 'microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 53-53, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1136752


    Harvard: Author-Date Style

    Asadi, M. and Caner, A. and Zafari, V. and Al Omar, A. and Müftüoğlu, C. and Asvadi Kermani, T. (2022) ‘microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER’, Journal of Advanced Research in Health Sciences, 5(1), pp. 53-53. https://doi.org/10.26650/JARHS2021-1136752 (24 Feb. 2024).


    MLA

    Asadi, Milad, and Ayşe Caner and Venus Zafari and Ahmed Al Omar and Can Müftüoğlu and Tuoraj Asvadi Kermani. microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 53-53. [Database Container], https://doi.org/10.26650/JARHS2021-1136752


    Vancouver

    Asadi M, Caner A, Zafari V, Al Omar A, Müftüoğlu C, Asvadi Kermani T. microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):53-53. Available from: https://doi.org/10.26650/JARHS2021-1136752 doi: 10.26650/JARHS2021-1136752


    ISNAD

    Asadi, Milad - Caner, Ayşe - Zafari, Venus - Al Omar, Ahmed - Müftüoğlu, Can - Asvadi Kermani, Tuoraj. microRNA AS A PROMISING POTENTIAL BIOMARKER FOR COLORECTAL CANCER”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 53-53. https://doi.org/10.26650/JARHS2021-1136752



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    Published Online09.08.2022

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