COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN  PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY

Ayan Durmuş; Zeybek Aydoğan Kader; Balcı Tevfik; Özmen Esma; Karabay Umut

doi:https://dx.doi.org/10.26650/JARHS2023-1183085

Research Article

DOI :10.26650/JARHS2023-1183085 IUP :10.26650/JARHS2023-1183085 Full Text (PDF)

COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY

Durmuş Ayan, Kader Zeybek Aydoğan, Tevfik Balcı, Esma Özmen, Umut Karabay

Objective: In our study, we aimed to compare Triglyceride/Glucose (TyG) index, LDL-C/HDL-C ratio, Triglyceride/HDL-C ratio, and Neutrophil/ Lymphocyte Ratio (NLR) with the HOMA-IR index in non-diabetes and prediabetes. Material and methods: A total of 1433 patients were included 673 women, and 890 men, aged between 18-75 years, applied to Niğde Ömer Halisdemir University Training and Research Hospital between 2019-2021 in our study. HOMA-IR index, TyG index, LDL-C/HDL-C ratio, Triglyceride/ HDL-C ratio, and NLO values were calculated by means of the analyzed tests. Results: According to our findings, the sensitivity and specificity of the Triglyceride/HDL-C ratio in the non-diabetic group and the NLR in the prediabetic group were higher than the routinely used method, the HOMA-IR index, as well as other indexes used in IR estimation. In addition, while a positive significant correlation was found between the Triglyceride/HDL-C ratio and the HOMA-IR index in the non-diabetic group (r=0.219; p<0.001), there was no significant correlation between NLR and HOMA-IR index in the pre-diabetic group (r=0.219; p<0.001), r=0.034; p=0.290). Conclusion: NLR may be an alternative parameter to predict IR in prediabetic patients. However, we think that there is a need for prospective studies that are verified by the reference method.

Keywords: Triglyceride/HDL-C ratio, TyG index, HOMA-IR ratio, LDL-C/ HDL-C ratio, NLO insulin resistance, metabolic syndrome

DOI :10.26650/JARHS2023-1183085 IUP :10.26650/JARHS2023-1183085 Full Text (PDF)

NÖTROFİL/LENFOSİT ORANI PREDİYABETİK HASTALARDA İNSÜLİN DİRENCİ TAHMİNİNDE HOMA-IR İNDEKSİNE ALTERNATİF BİR BELİRTEÇ OLABİLİR Mİ?: BİR RETROSPEKTİF ÇALIŞMA

Durmuş Ayan, Kader Zeybek Aydoğan, Tevfik Balcı, Esma Özmen, Umut Karabay

Amaç: Çalışmamızda prediyabet ve diyabet olmayan hastalarda HOMA-IR indeksi ile Trigliserid/Glukoz (TyG) indeksi, LDL-K/HDL-K oranını, Trigliserid/ HDL-K oranını ve Nötrofil/ Lenfosit Oranını (NLO) bir biri ile karşılaştırmayı amaçladık. Gereç ve Yöntem: Çalışmamıza Niğde Ömer Halisdemir Üniversitesi Eğitim ve Araştırma Hastanesine 2019-2021 yılları arasında başvuran 18-75 yaş arasında 673’ü kadın 890’ü erkeklerden oluşan toplam 1433 hasta dahil edilmiştir. HOMA-IR indeksi, TyG indeksi, LDL-K/HDL-K oranı, Trigliserid/ HDL-K oranı, NLO hesaplamaları analizi yapılan testler vasıtasıyla yapılmıştır. Bulgular: Bulgularımıza göre diyabetik olmayan grupta Trigliserid/HDL-K oranının ve pre-diyabetik grupta NLO’nun rutinde kullanılan yöntem olan HOMA-IR indeksine göre hem de IR tahmininde kullanılan diğer indekslere göre duyarlılığı ve özgüllüğünün daha yüksek olduğu tespit edildi. Ayrıca diyabetik olmayan grupta Trigliserid/HDL-K oranı ile HOMA-IR indeksi arasında pozitif anlamlı bir korelasyon sonucuna ulaşılırken (r=0,219; p<0,001), pre-diyabetik grupta NLO ile HOMA-IR indeksi arasında anlamlı bir korelasyon sonucu bulunamadı (r=0,034; p=0,290). Sonuç: Sonuç olarak, NLO pre-diyabetik hastalarda IR tahmininde HOMAIR yerine alternatif bir parametre olabilir. Ancak bunun referans yöntem ile verifikasyonu yapılan prospektif çalışmalar ile doğrulanması gerektiği düşüncesindeyiz.

Keywords: Trigliserid/HDL-K oranı, TyG indeksi, HOMA-IR oranı, LDL-K/HDL-K oranı, NLO insülin resistansı, metabolik sendrom

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APA

Ayan, D., Zeybek Aydoğan, K., Balcı, T., Özmen, E., & Karabay, U. (2023). COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY. Journal of Advanced Research in Health Sciences, 6(1), 33-39. https://doi.org/10.26650/JARHS2023-1183085

AMA

Ayan D, Zeybek Aydoğan K, Balcı T, Özmen E, Karabay U. COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY. Journal of Advanced Research in Health Sciences. 2023;6(1):33-39. https://doi.org/10.26650/JARHS2023-1183085

ABNT

Ayan, D.; Zeybek Aydoğan, K.; Balcı, T.; Özmen, E.; Karabay, U. COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 6, n. 1, p. 33-39, 2023.

Chicago: Author-Date Style

Ayan, Durmuş, and Kader Zeybek Aydoğan and Tevfik Balcı and Esma Özmen and Umut Karabay. 2023. “COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY.” Journal of Advanced Research in Health Sciences 6, no. 1: 33-39. https://doi.org/10.26650/JARHS2023-1183085

Chicago: Humanities Style

Ayan, Durmuş, and Kader Zeybek Aydoğan and Tevfik Balcı and Esma Özmen and Umut Karabay. “COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY.” Journal of Advanced Research in Health Sciences 6, no. 1 (Mar. 2023): 33-39. https://doi.org/10.26650/JARHS2023-1183085

Harvard: Australian Style

Ayan, D & Zeybek Aydoğan, K & Balcı, T & Özmen, E & Karabay, U 2023, 'COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY', Journal of Advanced Research in Health Sciences, vol. 6, no. 1, pp. 33-39, viewed 28 Mar. 2023, https://doi.org/10.26650/JARHS2023-1183085

Harvard: Author-Date Style

Ayan, D. and Zeybek Aydoğan, K. and Balcı, T. and Özmen, E. and Karabay, U. (2023) ‘COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY’, Journal of Advanced Research in Health Sciences, 6(1), pp. 33-39. https://doi.org/10.26650/JARHS2023-1183085 (28 Mar. 2023).

MLA

Ayan, Durmuş, and Kader Zeybek Aydoğan and Tevfik Balcı and Esma Özmen and Umut Karabay. “COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY.” Journal of Advanced Research in Health Sciences, vol. 6, no. 1, 2023, pp. 33-39. [Database Container], https://doi.org/10.26650/JARHS2023-1183085

Vancouver

Ayan D, Zeybek Aydoğan K, Balcı T, Özmen E, Karabay U. COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY. Journal of Advanced Research in Health Sciences [Internet]. 28 Mar. 2023 [cited 28 Mar. 2023];6(1):33-39. Available from: https://doi.org/10.26650/JARHS2023-1183085 doi: 10.26650/JARHS2023-1183085

ISNAD

Ayan, Durmuş - Zeybek Aydoğan, Kader - Balcı, Tevfik - Özmen, Esma - Karabay, Umut. “COULD THE NEUTROPHIL/LYMPHOCYTE RATIO BE AN ALTERNATIVE MARKER FOR THE PREDICTION OF INSULIN RESISTANCE IN PREDIABETIC PATIENTS?: A RETROSPECTIVE STUDY”. Journal of Advanced Research in Health Sciences 6/1 (Mar. 2023): 33-39. https://doi.org/10.26650/JARHS2023-1183085

Volume 6, Issue 12023, P. 33-39

TIMELINE

Submitted	01.10.2022
Accepted	16.12.2022
Published Online	15.02.2023

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