Meeting Abstract


DOI :10.26650/JARHS2021-1136729   IUP :10.26650/JARHS2021-1136729    Full Text (PDF)

POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER

Milad AsadiAyşe CanerVenus ZafariAhmed Al OmarCan MüftüoğluShahram Ghasembaıglou

Objective: Laryngeal malignancy known as the most frequently diagnosed cancer between head and neck tumor, covering 2.4% of all tumors and is the 11th most occurrence and deadliest tumor in the world. Research has shown that microRNAs (miRNAs) play a considerable role in the development of laryngeal malignancy. Moreover, studies also focus on the relationship between clinical relevance and miRNA deregulation in cancer illness. According to recent evidence, miR-205, miR-126, miR-302, and miR-132 have possible roles in the carcinogenesis process of the LSCC. Therefore, in this research, we aimed to investigate whether there are any considerable changes in the microRNAs expression level and also if they have any remarkable potential as a prognostic or diagnostic biomarker for laryngeal squamous cell carcinoma (LSCC). Methods: Thirty LSCC patients were included in this research, and tumor tissues and healthy normal tissues were collected during laryngectomy. Total RNA extraction from the normal and cancer tissues was accomplished and after the quality control, cDNA was synthesized, and finally, target miRNAs expression was determined by qPCR. The expression level of genes and their relationship with the patient’s clinicopathological characteristics were analyzed using appropriate statistical tests. Results: According to the study results, miR-302 (fold change: 1.o5, P-value = 0.0001) and miR-132 (fold change: 1.28, P-value = 0.0001), is considerably overexpressed in cancer tissues compare to normal peripheral tissues. We also found that miR-126 (fold change: 0.251, P-value = 0.0001) and miR-205 (fold change: 0.241, P-value<0.0001) is down-regulated in LSCC tumor tissue. Among these microRNAs, only mir-205 expression had no association with clinical-pathological features in tumor tissue. Conclusion: The results of this research revealed the potential of the miR-302, miR-132, miR-126, and miR-205 as prognostic or diagnostic biomarkers in LSCC.


PDF View

References

    Citations

    Copy and paste a formatted citation or use one of the options to export in your chosen format


    EXPORT



    APA

    Asadi, M., Caner, A., Zafari, V., Al Omar, A., Müftüoğlu, C., & Ghasembaıglou, S. (2022). POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER. Journal of Advanced Research in Health Sciences, 5(1), 54-54. https://doi.org/10.26650/JARHS2021-1136729


    AMA

    Asadi M, Caner A, Zafari V, Al Omar A, Müftüoğlu C, Ghasembaıglou S. POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER. Journal of Advanced Research in Health Sciences. 2022;5(1):54-54. https://doi.org/10.26650/JARHS2021-1136729


    ABNT

    Asadi, M.; Caner, A.; Zafari, V.; Al Omar, A.; Müftüoğlu, C.; Ghasembaıglou, S. POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 54-54, 2022.


    Chicago: Author-Date Style

    Asadi, Milad, and Ayşe Caner and Venus Zafari and Ahmed Al Omar and Can Müftüoğlu and Shahram Ghasembaıglou. 2022. “POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER.” Journal of Advanced Research in Health Sciences 5, no. 1: 54-54. https://doi.org/10.26650/JARHS2021-1136729


    Chicago: Humanities Style

    Asadi, Milad, and Ayşe Caner and Venus Zafari and Ahmed Al Omar and Can Müftüoğlu and Shahram Ghasembaıglou. POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 54-54. https://doi.org/10.26650/JARHS2021-1136729


    Harvard: Australian Style

    Asadi, M & Caner, A & Zafari, V & Al Omar, A & Müftüoğlu, C & Ghasembaıglou, S 2022, 'POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 54-54, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1136729


    Harvard: Author-Date Style

    Asadi, M. and Caner, A. and Zafari, V. and Al Omar, A. and Müftüoğlu, C. and Ghasembaıglou, S. (2022) ‘POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER’, Journal of Advanced Research in Health Sciences, 5(1), pp. 54-54. https://doi.org/10.26650/JARHS2021-1136729 (24 Feb. 2024).


    MLA

    Asadi, Milad, and Ayşe Caner and Venus Zafari and Ahmed Al Omar and Can Müftüoğlu and Shahram Ghasembaıglou. POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 54-54. [Database Container], https://doi.org/10.26650/JARHS2021-1136729


    Vancouver

    Asadi M, Caner A, Zafari V, Al Omar A, Müftüoğlu C, Ghasembaıglou S. POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):54-54. Available from: https://doi.org/10.26650/JARHS2021-1136729 doi: 10.26650/JARHS2021-1136729


    ISNAD

    Asadi, Milad - Caner, Ayşe - Zafari, Venus - Al Omar, Ahmed - Müftüoğlu, Can - Ghasembaıglou, Shahram. POTENTIAL OF microRNAs AS A BIOMARKER FOR LARYNGEAL CANCER”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 54-54. https://doi.org/10.26650/JARHS2021-1136729



    TIMELINE


    Published Online09.08.2022

    LICENCE


    Attribution-NonCommercial (CC BY-NC)

    This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


    SHARE




    Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.