Meeting Abstract


DOI :10.26650/JARHS2021-1138755   IUP :10.26650/JARHS2021-1138755    Full Text (PDF)

THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS

Esra Esmeray SönmezTevfik HatipoğluXiaozhou HuHongling YuanAyça Erşen DanyeliAyla Anar ArıcıAhmet ŞeyhanlıZuhal Önder SivişBengü DemiragEda AtasevenDilek İnceZekiye AltunSafiye Aktaşİnci AlacacıoğluTuğba Önal SüzekNazan ÖzsanTaner Kemal ErdağElvan Çağlar ÇıtakSermin ÖzkalMehmet Ali ÖzcanNazan ÇetingülErdener ÖzerTezer KutlukNur OlgunCan Küçük

Objective: Next-generation sequencing (NGS)-based approaches facilitated the identification of genomic and transcriptomic alterations associated with the development of B-cell lymphomas. Identification of these aberrancies during diagnosis may be helpful in choosing the most appropriate targeted therapy. Follicular lymphoma and Burkitt lymphoma are B-cell non-Hodgkin lymphomas with the potential to benefit from molecular targeted therapy. Materials and Methods: Targeted sequencing or miRNA-Seq were performed on FFPE tumor tissues of FL and pediatric BL (pBL) cases, respectively, using the HiSeq system. Cancer- associated somatic mutations were identified in FL tumor tissue DNA samples through a computational bioinformatics pipeline. miRNAs overexpressed in pBL cases compared with the tonsil centroblasts of non-cancer control cases were identified through differential expression analyses. Sanger sequencing or qRT-PCR were used to cross-validate targeted NGS and miRNA-Seq results, respectively. The literature search was performed to evaluate the therapeutic potential of these somatic mutations and upregulated miRNAs. Results: Targeted sequencing of FL tumor tissues revealed activating mutations in genes of biological processes or oncogenic signaling pathways. Several miRNAs were identified to be significantly overexpressed in pBL cases. The literature search revealed that targeted therapeutic approaches may be available for the FL or pBL patients with the identified mutations or upregulated miRNAs in tumor tissues. Conclusion: Targeted NGS may be applied during diagnosis to choose appropriate therapy for FL patients. Upregulated miRNAs provide unique opportunities for personalized targeted therapy of pBL patients.


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    APA

    Sönmez, E.E., Hatipoğlu, T., Hu, X., Yuan, H., Erşen Danyeli, A., Anar Arıcı, A., Şeyhanlı, A., Önder Siviş, Z., Demirag, B., Ataseven, E., İnce, D., Altun, Z., Aktaş, S., Alacacıoğlu, I., Önal Süzek, T., Özsan, N., Erdağ, T.K., Çağlar Çıtak, E., Özkal, S., Özcan, M.A., Çetingül, N., Özer, E., Kutluk, T., Olgun, N., & Küçük, C. (2022). THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS. Journal of Advanced Research in Health Sciences, 5(1), 31-31. https://doi.org/10.26650/JARHS2021-1138755


    AMA

    Sönmez E E, Hatipoğlu T, Hu X, Yuan H, Erşen Danyeli A, Anar Arıcı A, Şeyhanlı A, Önder Siviş Z, Demirag B, Ataseven E, İnce D, Altun Z, Aktaş S, Alacacıoğlu I, Önal Süzek T, Özsan N, Erdağ T K, Çağlar Çıtak E, Özkal S, Özcan M A, Çetingül N, Özer E, Kutluk T, Olgun N, Küçük C. THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS. Journal of Advanced Research in Health Sciences. 2022;5(1):31-31. https://doi.org/10.26650/JARHS2021-1138755


    ABNT

    Sönmez, E.E.; Hatipoğlu, T.; Hu, X.; Yuan, H.; Erşen Danyeli, A.; Anar Arıcı, A.; Şeyhanlı, A.; Önder Siviş, Z.; Demirag, B.; Ataseven, E.; İnce, D.; Altun, Z.; Aktaş, S.; Alacacıoğlu, I.; Önal Süzek, T.; Özsan, N.; Erdağ, T.K.; Çağlar Çıtak, E.; Özkal, S.; Özcan, M.A.; Çetingül, N.; Özer, E.; Kutluk, T.; Olgun, N.; Küçük, C. THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 31-31, 2022.


    Chicago: Author-Date Style

    Sönmez, Esra Esmeray, and Tevfik Hatipoğlu and Xiaozhou Hu and Hongling Yuan and Ayça Erşen Danyeli and Ayla Anar Arıcı and Ahmet Şeyhanlı and Zuhal Önder Siviş and Bengü Demirag and Eda Ataseven and Dilek İnce and Zekiye Altun and Safiye Aktaş and İnci Alacacıoğlu and Tuğba Önal Süzek and Nazan Özsan and Taner Kemal Erdağ and Elvan Çağlar Çıtak and Sermin Özkal and Mehmet Ali Özcan and Nazan Çetingül and Erdener Özer and Tezer Kutluk and Nur Olgun and Can Küçük. 2022. “THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS.” Journal of Advanced Research in Health Sciences 5, no. 1: 31-31. https://doi.org/10.26650/JARHS2021-1138755


    Chicago: Humanities Style

    Sönmez, Esra Esmeray, and Tevfik Hatipoğlu and Xiaozhou Hu and Hongling Yuan and Ayça Erşen Danyeli and Ayla Anar Arıcı and Ahmet Şeyhanlı and Zuhal Önder Siviş and Bengü Demirag and Eda Ataseven and Dilek İnce and Zekiye Altun and Safiye Aktaş and İnci Alacacıoğlu and Tuğba Önal Süzek and Nazan Özsan and Taner Kemal Erdağ and Elvan Çağlar Çıtak and Sermin Özkal and Mehmet Ali Özcan and Nazan Çetingül and Erdener Özer and Tezer Kutluk and Nur Olgun and Can Küçük. THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 31-31. https://doi.org/10.26650/JARHS2021-1138755


    Harvard: Australian Style

    Sönmez, EE & Hatipoğlu, T & Hu, X & Yuan, H & Erşen Danyeli, A & Anar Arıcı, A & Şeyhanlı, A & Önder Siviş, Z & Demirag, B & Ataseven, E & İnce, D & Altun, Z & Aktaş, S & Alacacıoğlu, I & Önal Süzek, T & Özsan, N & Erdağ, TK & Çağlar Çıtak, E & Özkal, S & Özcan, MA & Çetingül, N & Özer, E & Kutluk, T & Olgun, N & Küçük, C 2022, 'THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 31-31, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1138755


    Harvard: Author-Date Style

    Sönmez, E.E. and Hatipoğlu, T. and Hu, X. and Yuan, H. and Erşen Danyeli, A. and Anar Arıcı, A. and Şeyhanlı, A. and Önder Siviş, Z. and Demirag, B. and Ataseven, E. and İnce, D. and Altun, Z. and Aktaş, S. and Alacacıoğlu, I. and Önal Süzek, T. and Özsan, N. and Erdağ, T.K. and Çağlar Çıtak, E. and Özkal, S. and Özcan, M.A. and Çetingül, N. and Özer, E. and Kutluk, T. and Olgun, N. and Küçük, C. (2022) ‘THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS’, Journal of Advanced Research in Health Sciences, 5(1), pp. 31-31. https://doi.org/10.26650/JARHS2021-1138755 (24 Feb. 2024).


    MLA

    Sönmez, Esra Esmeray, and Tevfik Hatipoğlu and Xiaozhou Hu and Hongling Yuan and Ayça Erşen Danyeli and Ayla Anar Arıcı and Ahmet Şeyhanlı and Zuhal Önder Siviş and Bengü Demirag and Eda Ataseven and Dilek İnce and Zekiye Altun and Safiye Aktaş and İnci Alacacıoğlu and Tuğba Önal Süzek and Nazan Özsan and Taner Kemal Erdağ and Elvan Çağlar Çıtak and Sermin Özkal and Mehmet Ali Özcan and Nazan Çetingül and Erdener Özer and Tezer Kutluk and Nur Olgun and Can Küçük. THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 31-31. [Database Container], https://doi.org/10.26650/JARHS2021-1138755


    Vancouver

    Sönmez EE, Hatipoğlu T, Hu X, Yuan H, Erşen Danyeli A, Anar Arıcı A, Şeyhanlı A, Önder Siviş Z, Demirag B, Ataseven E, İnce D, Altun Z, Aktaş S, Alacacıoğlu I, Önal Süzek T, Özsan N, Erdağ TK, Çağlar Çıtak E, Özkal S, Özcan MA, Çetingül N, Özer E, Kutluk T, Olgun N, Küçük C. THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):31-31. Available from: https://doi.org/10.26650/JARHS2021-1138755 doi: 10.26650/JARHS2021-1138755


    ISNAD

    Sönmez, EsraEsmeray - Hatipoğlu, Tevfik - Hu, Xiaozhou - Yuan, Hongling - Erşen Danyeli, Ayça - Anar Arıcı, Ayla - Şeyhanlı, Ahmet - Önder Siviş, Zuhal - Demirag, Bengü - Ataseven, Eda - İnce, Dilek - Altun, Zekiye - Aktaş, Safiye - Alacacıoğlu, İnci - Önal Süzek, Tuğba - Özsan, Nazan - Erdağ, TanerKemal - Çağlar Çıtak, Elvan - Özkal, Sermin - Özcan, MehmetAli - Çetingül, Nazan - Özer, Erdener - Kutluk, Tezer - Olgun, Nur - Küçük, Can. THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 31-31. https://doi.org/10.26650/JARHS2021-1138755



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    Published Online09.08.2022

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