Meeting Abstract


DOI :10.26650/JARHS2021-1137404   IUP :10.26650/JARHS2021-1137404    Full Text (PDF)

TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER

Gözde Kuru TürkcanDemet Akdeniz ÖdemişBüşra KurtŞeref Buğra TunçerSeda Kılıç ErciyasÖzge Şükrüoğlu ErdoğanHülya Yazıcı

Objectives: The most significant barrier to treating epithelial ovarian cancer(EOC), is the late diagnosis and the emergence of chemotherapy resistance in the early stages.The ineffectiveness of standard treatment protocols in advanced-stage cases highlights the value of individualized EOC treatment.Even monozygotic(MZ) twins, with almost the same genotype in nature, can develop different phenotypic characteristics throughout life. Materials-Methods: In this context, the peripheral blood and ovarian tissues of monozygotic twins who are discordant in terms of ovarian cancer and the other healthy sibling who is a BRCA1 mutation carrier were compared in the study to analyze all RNA molecules transcribed at the genome level using next-generation sequencing technology.Through analyzing the molecules transcribed in the whole genome,the genetic variations underlying the development of ovarian cancer in a high-risk family bearing the BRCA1 mutation but only one of whom was found to have ovarian cancer were examined. Results: As a result of the transcriptomic analysis of the total RNA of 6 samples obtained from the ovarian tissues and peripheral blood samples of MZ twins with ovarian cancer and healthy sibling, the protein-encoding protein that shows expression changes in tissue and blood compared to healthy people genes,lncRNAs,precursor-miRNAs and fusion-transcripts have been identified.Filtering procedures and expression change coefficients(log2Fc) were calculated based on the expression data of identified ovarian cancer tumor markers CA125 and CA15-3. Conclusions: According to our study the expression levels of 66 protein-coding genes,23 novel lncRNAs,9 miRNAs and,2 fusion transcripts were found to vary in three groups and,these molecules are thought to be candidate molecules associated with epithelial ovarian cancer.


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    APA

    Kuru Türkcan, G., Akdeniz Ödemiş, D., Kurt, B., Tunçer, Ş.B., Kılıç Erciyas, S., Şükrüoğlu Erdoğan, Ö., & Yazıcı, H. (2022). TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER. Journal of Advanced Research in Health Sciences, 5(1), 36-36. https://doi.org/10.26650/JARHS2021-1137404


    AMA

    Kuru Türkcan G, Akdeniz Ödemiş D, Kurt B, Tunçer Ş B, Kılıç Erciyas S, Şükrüoğlu Erdoğan Ö, Yazıcı H. TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER. Journal of Advanced Research in Health Sciences. 2022;5(1):36-36. https://doi.org/10.26650/JARHS2021-1137404


    ABNT

    Kuru Türkcan, G.; Akdeniz Ödemiş, D.; Kurt, B.; Tunçer, Ş.B.; Kılıç Erciyas, S.; Şükrüoğlu Erdoğan, Ö.; Yazıcı, H. TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 36-36, 2022.


    Chicago: Author-Date Style

    Kuru Türkcan, Gözde, and Demet Akdeniz Ödemiş and Büşra Kurt and Şeref Buğra Tunçer and Seda Kılıç Erciyas and Özge Şükrüoğlu Erdoğan and Hülya Yazıcı. 2022. “TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER.” Journal of Advanced Research in Health Sciences 5, no. 1: 36-36. https://doi.org/10.26650/JARHS2021-1137404


    Chicago: Humanities Style

    Kuru Türkcan, Gözde, and Demet Akdeniz Ödemiş and Büşra Kurt and Şeref Buğra Tunçer and Seda Kılıç Erciyas and Özge Şükrüoğlu Erdoğan and Hülya Yazıcı. TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 36-36. https://doi.org/10.26650/JARHS2021-1137404


    Harvard: Australian Style

    Kuru Türkcan, G & Akdeniz Ödemiş, D & Kurt, B & Tunçer, ŞB & Kılıç Erciyas, S & Şükrüoğlu Erdoğan, Ö & Yazıcı, H 2022, 'TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 36-36, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1137404


    Harvard: Author-Date Style

    Kuru Türkcan, G. and Akdeniz Ödemiş, D. and Kurt, B. and Tunçer, Ş.B. and Kılıç Erciyas, S. and Şükrüoğlu Erdoğan, Ö. and Yazıcı, H. (2022) ‘TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER’, Journal of Advanced Research in Health Sciences, 5(1), pp. 36-36. https://doi.org/10.26650/JARHS2021-1137404 (24 Feb. 2024).


    MLA

    Kuru Türkcan, Gözde, and Demet Akdeniz Ödemiş and Büşra Kurt and Şeref Buğra Tunçer and Seda Kılıç Erciyas and Özge Şükrüoğlu Erdoğan and Hülya Yazıcı. TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 36-36. [Database Container], https://doi.org/10.26650/JARHS2021-1137404


    Vancouver

    Kuru Türkcan G, Akdeniz Ödemiş D, Kurt B, Tunçer ŞB, Kılıç Erciyas S, Şükrüoğlu Erdoğan Ö, Yazıcı H. TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):36-36. Available from: https://doi.org/10.26650/JARHS2021-1137404 doi: 10.26650/JARHS2021-1137404


    ISNAD

    Kuru Türkcan, Gözde - Akdeniz Ödemiş, Demet - Kurt, Büşra - Tunçer, ŞerefBuğra - Kılıç Erciyas, Seda - Şükrüoğlu Erdoğan, Özge - Yazıcı, Hülya. TRANSCRIPTOMIC DIFFERENCES IN MONOZYGOTIC TWINS WITH OVARIAN CANCER”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 36-36. https://doi.org/10.26650/JARHS2021-1137404



    TIMELINE


    Published Online09.08.2022

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