A Comparison of Fas-Fas Ligand Mediated Apoptosis with  Clinical and Pathological Parameters in Larynx Cancers;  Twenty Years After Laryngectomy

Bilgili Ahmet; Ersözlü Tolga

doi:https://dx.doi.org/10.26650/Tr-ENT.2022.1039303

Research Article

DOI :10.26650/Tr-ENT.2022.1039303 IUP :10.26650/Tr-ENT.2022.1039303 Full Text (PDF)

A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy

Objective: Larynx cancer constitutes 2% of all cancers in adults with 96% of larynx malignancies being squamous cell carcinoma (SHC). Apoptosis is a cell death mechanism that is quite different from necrosis. It is also known as programmed cell death, physiological cell death, or cell suicide. Physiological mediators that activate programmed cell death (apoptosis) are Fas and Fas Ligand (FasL). Materials and Methods: In a thesis study conducted by our authors in 2004, we investigated the relationship of Fas-Fas ligand-mediated apoptosis with survival in laryngeal cancer, prognostic factors (age, localization, histological grade, tumor size, lymph, blood vessel invasion), stage, and inflammatory response of the tumor. In this study, we investigated the relationship between survival and death rates after 20 years and Fas-FasL. Results: When FAS was evaluated 20 years later, a statistically significant difference was found between mortality rates depending on stage (p=0.023; p<0.05). While the survival rate is higher in stage 1 cases, the rate of death is higher in stage 3 cases. No statistically significant difference was found between mortality rates according to stages for FAS Ligand 20 years later (p>0.05). Conclusion: In conclusion, we found that the Fas/Fas-L system was not associated with clinical parameters in laryngeal cancers in our short-term follow-up. However, when we repeated our follow-up 20 years later, we found that Fas system deficiency, although not in FAS Ligand, adversely affected survival in the long term in laryngeal cancer patients.

Keywords: Fas, Fas ligand, laryngectomy, larynx cancer, squamous cell tumor

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APA

Bilgili, A.M., & Ersözlü, T. (2022). A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. The Turkish Journal of Ear Nose and Throat, 32(2), 37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303

AMA

Bilgili A M, Ersözlü T. A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. The Turkish Journal of Ear Nose and Throat. 2022;32(2):37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303

ABNT

Bilgili, A.M.; Ersözlü, T. A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. The Turkish Journal of Ear Nose and Throat, [Publisher Location], v. 32, n. 2, p. 37-42, 2022.

Chicago: Author-Date Style

Bilgili, Ahmet Mert, and Tolga Ersözlü. 2022. “A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy.” The Turkish Journal of Ear Nose and Throat 32, no. 2: 37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303

Chicago: Humanities Style

Bilgili, Ahmet Mert, and Tolga Ersözlü. “A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy.” The Turkish Journal of Ear Nose and Throat 32, no. 2 (Oct. 2023): 37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303

Harvard: Australian Style

Bilgili, AM & Ersözlü, T 2022, 'A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy', The Turkish Journal of Ear Nose and Throat, vol. 32, no. 2, pp. 37-42, viewed 4 Oct. 2023, https://doi.org/10.26650/Tr-ENT.2022.1039303

Harvard: Author-Date Style

Bilgili, A.M. and Ersözlü, T. (2022) ‘A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy’, The Turkish Journal of Ear Nose and Throat, 32(2), pp. 37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303 (4 Oct. 2023).

MLA

Bilgili, Ahmet Mert, and Tolga Ersözlü. “A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy.” The Turkish Journal of Ear Nose and Throat, vol. 32, no. 2, 2022, pp. 37-42. [Database Container], https://doi.org/10.26650/Tr-ENT.2022.1039303

Vancouver

Bilgili AM, Ersözlü T. A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy. The Turkish Journal of Ear Nose and Throat [Internet]. 4 Oct. 2023 [cited 4 Oct. 2023];32(2):37-42. Available from: https://doi.org/10.26650/Tr-ENT.2022.1039303 doi: 10.26650/Tr-ENT.2022.1039303

ISNAD

Bilgili, AhmetMert - Ersözlü, Tolga. “A Comparison of Fas-Fas Ligand Mediated Apoptosis with Clinical and Pathological Parameters in Larynx Cancers; Twenty Years After Laryngectomy”. The Turkish Journal of Ear Nose and Throat 32/2 (Oct. 2023): 37-42. https://doi.org/10.26650/Tr-ENT.2022.1039303

Volume 32, Issue 22022, P. 37-42

TIMELINE

Submitted	22.12.2021
Accepted	11.05.2022
Published Online	03.06.2022

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