Research Article


DOI :10.26650/Tr-ENT.2022.1077135   IUP :10.26650/Tr-ENT.2022.1077135    Full Text (PDF)

Evaluation of LRIG1 Expression in Larynx Pathologies

Yavuz GündoğduOrhan AsyaAyşegül GönenTajaddin MuradovSelim Yiğit ErçetinZeliha Leyla CinelAli Cemal Yumuşakhuylu

Objective: Studies have been performed on many biomolecules to determine the prognosis of LSCC and predict the course of the disease. However, a molecular marker that can be used clinically has not yet been found. Therefore, in this study, we aimed to investigate the expression levels of LRIG 1 in laryngeal cancer. Materials and Methods: In our study, 219 cases who underwent surgery due to LSCC and 88 randomly selected patients whose pathologic result were benign and premalignant lesions in Marmara University Pendik Education and Research Hospital between 2003 and 2018 were analyzed. Patients’ data were obtained from the medical records. The tissue microarray method was used to evaluate specimens. Results: There was a statistically significant difference between the tumor differentiation, diagnosis, and the expression of LRIG1 (respectively p=0.045, p<0.001). Also, an increase in the degree of dysplasia in premalignant lesions correlates with a decrease in LRIG1 expression (p=0.015). Conclusion: Our findings suggest that LRIG1 plays a role in the early tumorigenesis of LSCC. Therefore, LRIG1 can be a target molecule for treatment approaches. However, LRIG1 was not correlated with overall survival of the LSCC.


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APA

Gündoğdu, Y., Asya, O., Gönen, A., Muradov, T., Erçetin, S.Y., Cinel, Z.L., & Yumuşakhuylu, A.C. (2022). Evaluation of LRIG1 Expression in Larynx Pathologies. The Turkish Journal of Ear Nose and Throat, 32(2), 31-36. https://doi.org/10.26650/Tr-ENT.2022.1077135


AMA

Gündoğdu Y, Asya O, Gönen A, Muradov T, Erçetin S Y, Cinel Z L, Yumuşakhuylu A C. Evaluation of LRIG1 Expression in Larynx Pathologies. The Turkish Journal of Ear Nose and Throat. 2022;32(2):31-36. https://doi.org/10.26650/Tr-ENT.2022.1077135


ABNT

Gündoğdu, Y.; Asya, O.; Gönen, A.; Muradov, T.; Erçetin, S.Y.; Cinel, Z.L.; Yumuşakhuylu, A.C. Evaluation of LRIG1 Expression in Larynx Pathologies. The Turkish Journal of Ear Nose and Throat, [Publisher Location], v. 32, n. 2, p. 31-36, 2022.


Chicago: Author-Date Style

Gündoğdu, Yavuz, and Orhan Asya and Ayşegül Gönen and Tajaddin Muradov and Selim Yiğit Erçetin and Zeliha Leyla Cinel and Ali Cemal Yumuşakhuylu. 2022. “Evaluation of LRIG1 Expression in Larynx Pathologies.” The Turkish Journal of Ear Nose and Throat 32, no. 2: 31-36. https://doi.org/10.26650/Tr-ENT.2022.1077135


Chicago: Humanities Style

Gündoğdu, Yavuz, and Orhan Asya and Ayşegül Gönen and Tajaddin Muradov and Selim Yiğit Erçetin and Zeliha Leyla Cinel and Ali Cemal Yumuşakhuylu. Evaluation of LRIG1 Expression in Larynx Pathologies.” The Turkish Journal of Ear Nose and Throat 32, no. 2 (Oct. 2022): 31-36. https://doi.org/10.26650/Tr-ENT.2022.1077135


Harvard: Australian Style

Gündoğdu, Y & Asya, O & Gönen, A & Muradov, T & Erçetin, SY & Cinel, ZL & Yumuşakhuylu, AC 2022, 'Evaluation of LRIG1 Expression in Larynx Pathologies', The Turkish Journal of Ear Nose and Throat, vol. 32, no. 2, pp. 31-36, viewed 2 Oct. 2022, https://doi.org/10.26650/Tr-ENT.2022.1077135


Harvard: Author-Date Style

Gündoğdu, Y. and Asya, O. and Gönen, A. and Muradov, T. and Erçetin, S.Y. and Cinel, Z.L. and Yumuşakhuylu, A.C. (2022) ‘Evaluation of LRIG1 Expression in Larynx Pathologies’, The Turkish Journal of Ear Nose and Throat, 32(2), pp. 31-36. https://doi.org/10.26650/Tr-ENT.2022.1077135 (2 Oct. 2022).


MLA

Gündoğdu, Yavuz, and Orhan Asya and Ayşegül Gönen and Tajaddin Muradov and Selim Yiğit Erçetin and Zeliha Leyla Cinel and Ali Cemal Yumuşakhuylu. Evaluation of LRIG1 Expression in Larynx Pathologies.” The Turkish Journal of Ear Nose and Throat, vol. 32, no. 2, 2022, pp. 31-36. [Database Container], https://doi.org/10.26650/Tr-ENT.2022.1077135


Vancouver

Gündoğdu Y, Asya O, Gönen A, Muradov T, Erçetin SY, Cinel ZL, Yumuşakhuylu AC. Evaluation of LRIG1 Expression in Larynx Pathologies. The Turkish Journal of Ear Nose and Throat [Internet]. 2 Oct. 2022 [cited 2 Oct. 2022];32(2):31-36. Available from: https://doi.org/10.26650/Tr-ENT.2022.1077135 doi: 10.26650/Tr-ENT.2022.1077135


ISNAD

Gündoğdu, Yavuz - Asya, Orhan - Gönen, Ayşegül - Muradov, Tajaddin - Erçetin, SelimYiğit - Cinel, ZelihaLeyla - Yumuşakhuylu, AliCemal. Evaluation of LRIG1 Expression in Larynx Pathologies”. The Turkish Journal of Ear Nose and Throat 32/2 (Oct. 2022): 31-36. https://doi.org/10.26650/Tr-ENT.2022.1077135



TIMELINE


Submitted22.02.2022
Accepted26.04.2022
Published Online25.05.2022

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