Research Article


DOI :10.26650/Tr-ENT.2024.1402917   IUP :10.26650/Tr-ENT.2024.1402917    Full Text (PDF)

Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma

Saber CheboukiZeynep Nil ÜnalKemal Koray BalHarun GürOnur İsmiMurat Ünal

Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor (VDR) is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer.

Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study.

Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups.

Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group he/she is in, and VDR gene polymorphism can be used as a biomarker.


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APA

Chebouki, S., Ünal, Z.N., Bal, K.K., Gür, H., İsmi, O., & Ünal, M. (2024). Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat, 34(1), 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917


AMA

Chebouki S, Ünal Z N, Bal K K, Gür H, İsmi O, Ünal M. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat. 2024;34(1):1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917


ABNT

Chebouki, S.; Ünal, Z.N.; Bal, K.K.; Gür, H.; İsmi, O.; Ünal, M. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat, [Publisher Location], v. 34, n. 1, p. 1-7, 2024.


Chicago: Author-Date Style

Chebouki, Saber, and Zeynep Nil Ünal and Kemal Koray Bal and Harun Gür and Onur İsmi and Murat Ünal. 2024. “Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma.” The Turkish Journal of Ear Nose and Throat 34, no. 1: 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917


Chicago: Humanities Style

Chebouki, Saber, and Zeynep Nil Ünal and Kemal Koray Bal and Harun Gür and Onur İsmi and Murat Ünal. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma.” The Turkish Journal of Ear Nose and Throat 34, no. 1 (Apr. 2024): 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917


Harvard: Australian Style

Chebouki, S & Ünal, ZN & Bal, KK & Gür, H & İsmi, O & Ünal, M 2024, 'Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma', The Turkish Journal of Ear Nose and Throat, vol. 34, no. 1, pp. 1-7, viewed 23 Apr. 2024, https://doi.org/10.26650/Tr-ENT.2024.1402917


Harvard: Author-Date Style

Chebouki, S. and Ünal, Z.N. and Bal, K.K. and Gür, H. and İsmi, O. and Ünal, M. (2024) ‘Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma’, The Turkish Journal of Ear Nose and Throat, 34(1), pp. 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917 (23 Apr. 2024).


MLA

Chebouki, Saber, and Zeynep Nil Ünal and Kemal Koray Bal and Harun Gür and Onur İsmi and Murat Ünal. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma.” The Turkish Journal of Ear Nose and Throat, vol. 34, no. 1, 2024, pp. 1-7. [Database Container], https://doi.org/10.26650/Tr-ENT.2024.1402917


Vancouver

Chebouki S, Ünal ZN, Bal KK, Gür H, İsmi O, Ünal M. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat [Internet]. 23 Apr. 2024 [cited 23 Apr. 2024];34(1):1-7. Available from: https://doi.org/10.26650/Tr-ENT.2024.1402917 doi: 10.26650/Tr-ENT.2024.1402917


ISNAD

Chebouki, Saber - Ünal, ZeynepNil - Bal, KemalKoray - Gür, Harun - İsmi, Onur - Ünal, Murat. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma”. The Turkish Journal of Ear Nose and Throat 34/1 (Apr. 2024): 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917



TIMELINE


Submitted10.12.2023
Accepted14.03.2024
Published Online26.03.2024

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