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DOI :10.26650/EurJBiol.2022.1097509   IUP :10.26650/EurJBiol.2022.1097509    Tam Metin (PDF)

Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats

Ömercan AlbayrakDilek ÖzbeyliAli ŞenÖzge ÇevikÖmer ErdoğanFeriha ErcanFatma KanpaltaSeren EdeGöksel Şener

Objective: The aim is to examine the possible protective effect of Cuscuta sp. extract against liver damage induced by biliary obstruction in rats. Materials and Methods: To induce biliary obstruction, the bile duct ligation (BDL) method was used. Sprague Dawley rats were allocated to 4 groups: Control (C), Cuscuta (CUS), bile duct ligation (BDL), and bile duct ligation + Cuscuta (BDL+CUS). Control and BDL rats were given physiological saline (SF), while CUS and BDL+CUS groups were administered 250 mg/ kg of Cuscuta extract by oral gavage. At the end of 28th day, the rats were decapitated, serum and tissue samples were collected, and aspartate aminotransferase (AST), alanine transaminase (ALT), and direct and total bilirubin (DB and TB) levels were determined in blood samples. In liver tissues, transforming growth factor-β (TGF-β), 8-hydroxyguanosine (8-OHdG), hydroxyproline, and sodium–potassium ATPase (Na+/K+-ATPase) levels were determined. Results: Serum samples of rats with cholestasis had high ALT, AST, DB, and TB levels, while TGF-β, 8-OHdG, and hydroxyproline concentrations were found to be significantly high in tissues. Hepatic Na+/K+-ATPase levels were decreased through biliary obstruction. Biochemical parameters were drastically reversed by Cuscuta care; also, this was supported histologically. Conclusion: Results showed that Cuscuta extract, through its antioxidant and anti-inflammatory properties, provided protection against oxidative injury by biliary obstruction. Also, these results confirm the traditional use of Cuscuta sp. as hepatoprotective.


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DIŞA AKTAR



APA

Albayrak, Ö., Özbeyli, D., Şen, A., Çevik, Ö., Erdoğan, Ö., Ercan, F., Kanpalta, F., Ede, S., & Şener, G. (2022). Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats. European Journal of Biology, 81(1), 31-40. https://doi.org/10.26650/EurJBiol.2022.1097509


AMA

Albayrak Ö, Özbeyli D, Şen A, Çevik Ö, Erdoğan Ö, Ercan F, Kanpalta F, Ede S, Şener G. Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats. European Journal of Biology. 2022;81(1):31-40. https://doi.org/10.26650/EurJBiol.2022.1097509


ABNT

Albayrak, Ö.; Özbeyli, D.; Şen, A.; Çevik, Ö.; Erdoğan, Ö.; Ercan, F.; Kanpalta, F.; Ede, S.; Şener, G. Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats. European Journal of Biology, [Publisher Location], v. 81, n. 1, p. 31-40, 2022.


Chicago: Author-Date Style

Albayrak, Ömercan, and Dilek Özbeyli and Ali Şen and Özge Çevik and Ömer Erdoğan and Feriha Ercan and Fatma Kanpalta and Seren Ede and Göksel Şener. 2022. “Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats.” European Journal of Biology 81, no. 1: 31-40. https://doi.org/10.26650/EurJBiol.2022.1097509


Chicago: Humanities Style

Albayrak, Ömercan, and Dilek Özbeyli and Ali Şen and Özge Çevik and Ömer Erdoğan and Feriha Ercan and Fatma Kanpalta and Seren Ede and Göksel Şener. Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats.” European Journal of Biology 81, no. 1 (Nov. 2022): 31-40. https://doi.org/10.26650/EurJBiol.2022.1097509


Harvard: Australian Style

Albayrak, Ö & Özbeyli, D & Şen, A & Çevik, Ö & Erdoğan, Ö & Ercan, F & Kanpalta, F & Ede, S & Şener, G 2022, 'Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats', European Journal of Biology, vol. 81, no. 1, pp. 31-40, viewed 30 Nov. 2022, https://doi.org/10.26650/EurJBiol.2022.1097509


Harvard: Author-Date Style

Albayrak, Ö. and Özbeyli, D. and Şen, A. and Çevik, Ö. and Erdoğan, Ö. and Ercan, F. and Kanpalta, F. and Ede, S. and Şener, G. (2022) ‘Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats’, European Journal of Biology, 81(1), pp. 31-40. https://doi.org/10.26650/EurJBiol.2022.1097509 (30 Nov. 2022).


MLA

Albayrak, Ömercan, and Dilek Özbeyli and Ali Şen and Özge Çevik and Ömer Erdoğan and Feriha Ercan and Fatma Kanpalta and Seren Ede and Göksel Şener. Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats.” European Journal of Biology, vol. 81, no. 1, 2022, pp. 31-40. [Database Container], https://doi.org/10.26650/EurJBiol.2022.1097509


Vancouver

Albayrak Ö, Özbeyli D, Şen A, Çevik Ö, Erdoğan Ö, Ercan F, Kanpalta F, Ede S, Şener G. Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats. European Journal of Biology [Internet]. 30 Nov. 2022 [cited 30 Nov. 2022];81(1):31-40. Available from: https://doi.org/10.26650/EurJBiol.2022.1097509 doi: 10.26650/EurJBiol.2022.1097509


ISNAD

Albayrak, Ömercan - Özbeyli, Dilek - Şen, Ali - Çevik, Özge - Erdoğan, Ömer - Ercan, Feriha - Kanpalta, Fatma - Ede, Seren - Şener, Göksel. Dodder (Cuscuta sp.) Extract Ameliorates Liver Fibrosis in Bile Duct-Ligated Rats”. European Journal of Biology 81/1 (Nov. 2022): 31-40. https://doi.org/10.26650/EurJBiol.2022.1097509



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