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DOI :10.26650/experimed.1232534   IUP :10.26650/experimed.1232534    Tam Metin (PDF)

Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population

Gözde ÖzcanFatma Tuba AkdenizSeda Güleç YılmazZerrin BarutDeryanaz BillurTurgay İsbirCumhur Kaan Yaltırık

Objective: Gliomas are devastating adult brain tumors of unknown etiology, occupying 8 out of 10 primary brain tumors. Epidermal growth factor receptor (EGFR) as a tyrosine kinase family member is encoded by the EGFR gene located in chromosome 7p12-13. Various studies have identified numerous SNPs, including those in the EGFR gene, as linked to gliomas. The objective of the investigation was to determine whether the genotype and allele frequencies of the EGFR may have a role in glioma susceptibility. Materials and Methods: To examine the association of EGFR SNP rs1468727 with glioma susceptibility in a case-control study from Türkiye (34 cases, 36 controls), genotyping and statistical analyses were performed by using real-time-polymerase chain reaction (RT-PCR) and SPSS version 25.0, respectively. Results: A significant relationship was found between the study groups EGFR SNP rs1468727 genotypes (p = 0.028). The CC genotype frequency was significantly greater in the control group compared to the glioma group (p=0.005). When compared with the control group, the frequency of mutant type T allele carriers was significantly higher in glioma patients (p=0.012). Conclusion: As a result of the preliminary findings, having the mutant T allele may increase risk by 3.36 times, whereas having the ancestral homozygote CC genotype lowers the risk for glioma in Turkish population.

Anahtar Kelimeler: GliomaEGFR genevariationSNP

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DIŞA AKTAR



APA

Özcan, G., Akdeniz, F., Güleç Yılmaz, S., Barut, Z., Billur, D., İsbir, T., & Yaltırık, C.K. (2023). Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population. Experimed, 13(1), 54-58. https://doi.org/10.26650/experimed.1232534


AMA

Özcan G, Akdeniz F, Güleç Yılmaz S, Barut Z, Billur D, İsbir T, Yaltırık C K. Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population. Experimed. 2023;13(1):54-58. https://doi.org/10.26650/experimed.1232534


ABNT

Özcan, G.; Akdeniz, F.; Güleç Yılmaz, S.; Barut, Z.; Billur, D.; İsbir, T.; Yaltırık, C.K. Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population. Experimed, [Publisher Location], v. 13, n. 1, p. 54-58, 2023.


Chicago: Author-Date Style

Özcan, Gözde, and Fatma Tuba Akdeniz and Seda Güleç Yılmaz and Zerrin Barut and Deryanaz Billur and Turgay İsbir and Cumhur Kaan Yaltırık. 2023. “Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population.” Experimed 13, no. 1: 54-58. https://doi.org/10.26650/experimed.1232534


Chicago: Humanities Style

Özcan, Gözde, and Fatma Tuba Akdeniz and Seda Güleç Yılmaz and Zerrin Barut and Deryanaz Billur and Turgay İsbir and Cumhur Kaan Yaltırık. Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population.” Experimed 13, no. 1 (Jul. 2024): 54-58. https://doi.org/10.26650/experimed.1232534


Harvard: Australian Style

Özcan, G & Akdeniz, F & Güleç Yılmaz, S & Barut, Z & Billur, D & İsbir, T & Yaltırık, CK 2023, 'Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population', Experimed, vol. 13, no. 1, pp. 54-58, viewed 16 Jul. 2024, https://doi.org/10.26650/experimed.1232534


Harvard: Author-Date Style

Özcan, G. and Akdeniz, F. and Güleç Yılmaz, S. and Barut, Z. and Billur, D. and İsbir, T. and Yaltırık, C.K. (2023) ‘Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population’, Experimed, 13(1), pp. 54-58. https://doi.org/10.26650/experimed.1232534 (16 Jul. 2024).


MLA

Özcan, Gözde, and Fatma Tuba Akdeniz and Seda Güleç Yılmaz and Zerrin Barut and Deryanaz Billur and Turgay İsbir and Cumhur Kaan Yaltırık. Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population.” Experimed, vol. 13, no. 1, 2023, pp. 54-58. [Database Container], https://doi.org/10.26650/experimed.1232534


Vancouver

Özcan G, Akdeniz F, Güleç Yılmaz S, Barut Z, Billur D, İsbir T, Yaltırık CK. Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population. Experimed [Internet]. 16 Jul. 2024 [cited 16 Jul. 2024];13(1):54-58. Available from: https://doi.org/10.26650/experimed.1232534 doi: 10.26650/experimed.1232534


ISNAD

Özcan, Gözde - Akdeniz, Fatma Tuba - Güleç Yılmaz, Seda - Barut, Zerrin - Billur, Deryanaz - İsbir, Turgay - Yaltırık, CumhurKaan. Association of EGFR Gene Polymorphism with Glioma Susceptibility in Turkish Population”. Experimed 13/1 (Jul. 2024): 54-58. https://doi.org/10.26650/experimed.1232534



ZAMAN ÇİZELGESİ


Gönderim11.01.2023
Kabul03.04.2023
Çevrimiçi Yayınlanma10.04.2023

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