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DOI :10.26650/experimed.1211125   IUP :10.26650/experimed.1211125    Tam Metin (PDF)

Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population

Esra AydemirDerya BurukçuGürcan VuralTaner KıvılcımFikrettin Şahin

Objective: Breast cancer has the highest incidence and mortality rate among women worldwide. This study aims to analyze ubiquitin specific protease 7 (USP7) levels in mammary ductal adenocarcinoma patients in the Turkish population, to identify whether there is a relationship between the levels of USP7 protein and bad prognosis, which is indicated by enlarged tumor size, younger age, and receiving neo-adjuvant treatment. Materials and Methods: In our study, we analyzed USP7 levels by immunohistochemistry (IHC) staining in 38 mammary adenocarcinoma cases in the Turkish population. Corelation analyses were performed to evaluate the distribution of the patients by their age, tumor size, Ki-67 levels, and the status of neo-adjuvant treatment by their USP7 levels. The IHC data concluded that the average age and tumor size are reversely proportional to the USP7 levels, insignificantly. The differences between the levels of USP7 and Ki-67 measurements were found to be statistically insignificant between the groups. Results: Women who received the neo-adjuvant therapy prior to the operation presented much lower amount of USP7 levels when compared to their non-treated counterparts. Conclusions: These findings highlighted that mammary ductal adenocarcinoma patients in the Turkish population present varying USP7 protein levels. Even though the levels of UPS7 are partially insignificant, the presence of USP7 protein might be a prognostic indicator in breast cancer patients in the Turkish population with a larger study set.


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APA

Aydemir, E., Burukçu, D., Vural, G., Kıvılcım, T., & Şahin, F. (2023). Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population. Experimed, 13(1), 21-25. https://doi.org/10.26650/experimed.1211125


AMA

Aydemir E, Burukçu D, Vural G, Kıvılcım T, Şahin F. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population. Experimed. 2023;13(1):21-25. https://doi.org/10.26650/experimed.1211125


ABNT

Aydemir, E.; Burukçu, D.; Vural, G.; Kıvılcım, T.; Şahin, F. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population. Experimed, [Publisher Location], v. 13, n. 1, p. 21-25, 2023.


Chicago: Author-Date Style

Aydemir, Esra, and Derya Burukçu and Gürcan Vural and Taner Kıvılcım and Fikrettin Şahin. 2023. “Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population.” Experimed 13, no. 1: 21-25. https://doi.org/10.26650/experimed.1211125


Chicago: Humanities Style

Aydemir, Esra, and Derya Burukçu and Gürcan Vural and Taner Kıvılcım and Fikrettin Şahin. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population.” Experimed 13, no. 1 (Jul. 2024): 21-25. https://doi.org/10.26650/experimed.1211125


Harvard: Australian Style

Aydemir, E & Burukçu, D & Vural, G & Kıvılcım, T & Şahin, F 2023, 'Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population', Experimed, vol. 13, no. 1, pp. 21-25, viewed 20 Jul. 2024, https://doi.org/10.26650/experimed.1211125


Harvard: Author-Date Style

Aydemir, E. and Burukçu, D. and Vural, G. and Kıvılcım, T. and Şahin, F. (2023) ‘Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population’, Experimed, 13(1), pp. 21-25. https://doi.org/10.26650/experimed.1211125 (20 Jul. 2024).


MLA

Aydemir, Esra, and Derya Burukçu and Gürcan Vural and Taner Kıvılcım and Fikrettin Şahin. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population.” Experimed, vol. 13, no. 1, 2023, pp. 21-25. [Database Container], https://doi.org/10.26650/experimed.1211125


Vancouver

Aydemir E, Burukçu D, Vural G, Kıvılcım T, Şahin F. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population. Experimed [Internet]. 20 Jul. 2024 [cited 20 Jul. 2024];13(1):21-25. Available from: https://doi.org/10.26650/experimed.1211125 doi: 10.26650/experimed.1211125


ISNAD

Aydemir, Esra - Burukçu, Derya - Vural, Gürcan - Kıvılcım, Taner - Şahin, Fikrettin. Significance of USP7 in Predicting Prognosis of Mammary Ductal Adenocarcinoma in the Turkish Population”. Experimed 13/1 (Jul. 2024): 21-25. https://doi.org/10.26650/experimed.1211125



ZAMAN ÇİZELGESİ


Gönderim28.11.2022
Kabul13.03.2023
Çevrimiçi Yayınlanma06.04.2023

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