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DOI :10.26650/experimed.1085407   IUP :10.26650/experimed.1085407    Tam Metin (PDF)

The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity

Bertan Boran BayrakDastagül Mahmarzayevaİsmet Burcu TürkyılmazÖzlem SaçanRefiye Yanardağ

Objective: The objective of the current work is to examine the protective effects of S-methyl methionine sulfonium chloride (MMSC) on brain in galactosamine (GalN)-induced hepatotoxicity in rats. Materials and Methods: A total of twenty two female Sprague-Dawley rats were randomly assigned into four groups as follows: Group I (n=5), intact control animals; Group II (n=6), animals that received 50 mg/kg/day of MMSC by gavage technique for 3 consecutive days; Group III (n=5), animals injected with a single dose of 500 mg/kg of GalN intraperitoneally (i.p.); and Group IV (n=6) are animals injected with the same dose of GalN (i.p.) 1 hour after MMSC treatment. At the end of the experiments (after 6 hours of the last GalN treatment), all animals were sacrificed under anaesthesia, and brain tissues were dissected out. Results: A statistically remarkable increase in lipid peroxidation, hydroxyproline, and nitric oxide levels, was detected while a notable decline in the activities of sodium/potassium ATPase was observed in GalN group in comparison with control rats. In contrast, all alterations observed were reversed when MMSC was given to GalN groups. Conclusion: Consequently, it may be considered that MMSC has a protective role on brain in GalN-induced hepatotoxicity in rats.


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APA

Bayrak, B.B., Mahmarzayeva, D., Türkyılmaz, İ.B., Saçan, Ö., & Yanardağ, R. (2022). The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity. Experimed, 12(2), 38-43. https://doi.org/10.26650/experimed.1085407


AMA

Bayrak B B, Mahmarzayeva D, Türkyılmaz İ B, Saçan Ö, Yanardağ R. The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity. Experimed. 2022;12(2):38-43. https://doi.org/10.26650/experimed.1085407


ABNT

Bayrak, B.B.; Mahmarzayeva, D.; Türkyılmaz, İ.B.; Saçan, Ö.; Yanardağ, R. The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity. Experimed, [Publisher Location], v. 12, n. 2, p. 38-43, 2022.


Chicago: Author-Date Style

Bayrak, Bertan Boran, and Dastagül Mahmarzayeva and İsmet Burcu Türkyılmaz and Özlem Saçan and Refiye Yanardağ. 2022. “The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity.” Experimed 12, no. 2: 38-43. https://doi.org/10.26650/experimed.1085407


Chicago: Humanities Style

Bayrak, Bertan Boran, and Dastagül Mahmarzayeva and İsmet Burcu Türkyılmaz and Özlem Saçan and Refiye Yanardağ. The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity.” Experimed 12, no. 2 (Dec. 2022): 38-43. https://doi.org/10.26650/experimed.1085407


Harvard: Australian Style

Bayrak, BB & Mahmarzayeva, D & Türkyılmaz, İB & Saçan, Ö & Yanardağ, R 2022, 'The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity', Experimed, vol. 12, no. 2, pp. 38-43, viewed 2 Dec. 2022, https://doi.org/10.26650/experimed.1085407


Harvard: Author-Date Style

Bayrak, B.B. and Mahmarzayeva, D. and Türkyılmaz, İ.B. and Saçan, Ö. and Yanardağ, R. (2022) ‘The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity’, Experimed, 12(2), pp. 38-43. https://doi.org/10.26650/experimed.1085407 (2 Dec. 2022).


MLA

Bayrak, Bertan Boran, and Dastagül Mahmarzayeva and İsmet Burcu Türkyılmaz and Özlem Saçan and Refiye Yanardağ. The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity.” Experimed, vol. 12, no. 2, 2022, pp. 38-43. [Database Container], https://doi.org/10.26650/experimed.1085407


Vancouver

Bayrak BB, Mahmarzayeva D, Türkyılmaz İB, Saçan Ö, Yanardağ R. The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity. Experimed [Internet]. 2 Dec. 2022 [cited 2 Dec. 2022];12(2):38-43. Available from: https://doi.org/10.26650/experimed.1085407 doi: 10.26650/experimed.1085407


ISNAD

Bayrak, BertanBoran - Mahmarzayeva, Dastagül - Türkyılmaz, İsmetBurcu - Saçan, Özlem - Yanardağ, Refiye. The Protective Effects of S-Methyl Methionine Sulfonium Chloride on Brain Tissue Damage in D-Galactosamine-Induced Hepatotoxicity”. Experimed 12/2 (Dec. 2022): 38-43. https://doi.org/10.26650/experimed.1085407



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