İstanbul Journal of Pharmacy

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DOI :10.26650/IstanbulJPharm.2022.975375   IUP :10.26650/IstanbulJPharm.2022.975375    Tam Metin (PDF)

A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men

Akinwumi Akinyinka Akinyede, Adedunni Olusanya, Hazees Olawale Mohammed, Olumuyiwa John Fasipe, Adesina Arikawe

Background and Aims: Erectile dysfunction is prevalent among men with hypertension, but there is paucity of data on prevalence of other domains of sexual dysfunction (SD) in hypertensives and the general population. The study compared the prevalence and patterns of SD among treated hypertensive male patients with normotensive men. The effect of antihypertensive drugs on different domains of sexual function was also investigated in our study. Methods: A total of 195 participants (95 hypertensive and 100 non-hypertensive men) were recruited from the medical out-patient department of a secondary health care facility in Lagos, Nigeria. Sexual function was assessed using International Index of Erectile Function (IIEF) which measures erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction. Results: Sexual dysfunction affecting at least one domain was present in 82.1% of the hypertensive subjects and 52% of non-hypertensive controls (P<0.001). The hypertensive patient had more severe dysfunction in the multiple domains (p< 0.001). The use of methyldopa, furosemide and ß-blockers were associated with significantly lower scores while there was no significant difference in scores with the use calcium channel blockers, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, thiazide and potassium sparing diuretics. SD was higher in the older age group and with longer duration of hypertension and treatment. Conclusion: SD is common in the adult male population with hypertension significantly increasing the risk. Hypertension is associated with involvement of multiple domains for sexual dysfunction. Use of methyldopa, furosemide and ß-blockers were associated with higher rates of SD in the hypertensive population.

Anahtar Kelimeler: Sexual dysfunction, Hypertension, Erectile dysfunction, antihypertensive drugs

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Referanslar

  • Akinyede, A. A., Nwaiwu, O., Fasipe, O. J., Olusanya, A., Olayemi, S.O., & Akande, B. (2020). A prospective study of the effect of antihypertensive medications on the sexual functions of hypertensive adult male patients. Future Science OA, 6(6), FSO479. doi:10.2144/ fsoa-2020-0030 google scholar
  • Artom, N., Pinna, G., Musso, N. R., Orlandini, F., Malasoma, P., Uccelli, M., . . . Pende, A. (2016). Prevalence of erectile dysfunction in a cohort of Italian hypertensive subjects. Clinical and Experimental Hypertension, 38(2), 143-149. doi:10.3109/10641963.2015.1060994 google scholar
  • Bleustein, C. B., Arezzo, J. C., Eckholdt, H., & Melman, A. (2002). The neuropathy of erectile dysfunction. International Journal of Impotence Research, 14(6), 433-439. doi:10.1038/sj.ijir.3900907. google scholar
  • Burnett, A. L. (2019). The science and practice of erection physiology: story of a revolutionary gaseous molecule. Transactions of the American Clinical and Climatological Association, 130, 51-59. google scholar
  • Chen, L., Shi, G. R., Huang, D. D., Li, Y., Ma, C. C., Shi, M., . . . Shi, G. J. (2019). Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention. Biomedicine and Pharmacotherapy, 112, 108585. doi:10.1016/j.biopha. 2019.01.046 google scholar
  • Doumas, M., Tsakiris, A., Douma, S., Grigorakis, A., Papadopoulos, A., Hounta, A., . . . Giamarellou, H. (2006). Factors affecting the increased prevalence of erectile dysfunction in Greek hypertensive compared with normotensive subjects. Journal of Andrology, 27(3), 469-477. doi:10.2164/jandrol.04191 google scholar
  • Derogatis, L. R., & Burnett, A. L. (2008). The epidemiology of sexual dysfunctions. The Journal of Sexual Medicine, 5(2), 289-300. doi:10.1111/j.1743-6109.2007.00668.x google scholar
  • Ekman, E., Hagg, S., Sundstrom, A., & Werkstrom, V. (2010). Antihypertensive drugs and erectile dysfunction as seen in spontaneous reports, with focus on angiotensin II type 1 receptor blockers. The Drug, Healthcare and Patient Safety, 2, 21-25. doi:10.2147/ dhps.s8432. google scholar
  • Fafiolu, A. S., Adebayo, A. M., Akande, T. O., & Akinboboye, O. O. (2014). Erectile dysfunction among male hypertensives in a tertiary health facility in South-West Nigeria. Global Journal of Health Science, 7(1), 154-160. doi:10.5539/gjhs.v7n1p154 google scholar
  • Fogari, R., & Zoppi, A. (2002). Effects of antihypertensive therapy on sexual activity in hypertensive men. Current Hypertension Reports, 4(3), 202-210. doi:10.1007/s11906-002-0008-3 google scholar
  • Foy, C. G., Newman, J. C., Berlowitz, D. R., Russell, L. P., Kimmel, P. L., Wadley, V. G., . . . Riley, W. T. (2016). Blood Pressure, Sexual Activity, and Dysfunction in Women With Hypertension: Baseline Findings From the Systolic Blood Pressure Intervention Trial (SPRINT). The Journal of Sexual Medicine, 13(9), 1333-1346. doi:10.1016/j. jsxm.2016.06.014 google scholar
  • Hanon, O., Mounier-Vehier, C., Fauvel, J. P., Marquand, A., Jaboureck, O., Justin, E. P., . . . Girerd, X. (2002). [Sexual dysfunction in treated hypertensive patients. Results of a national survey] . Archives des Maladies du Coeur et des Vaisseaux, 95(7-8), 673-677 google scholar
  • Healy, D., Le Noury, J., &Mangin, D. (2018). Enduring sexual dysfunction after treatment with antidepressants, 5a-reductase inhibitors and isotretinoin: 300 cases. The International Journal of Risk & Safety in Medicine, 29(3-4), 125-134. doi:10.3233/JRS-180744 google scholar
  • Imprialos, K. P., Stavropoulos, K., Doumas, M., Tziomalos, K., Kara-giannis, A., &Athyros, V. G. (2018). Sexual Dysfunction, Cardiovascular Risk and Effects of Pharmacotherapy. Current Vascular Pharmacology, 16(2), 130-142. Doi:10.2174/157016111566617060910 1502 google scholar
  • Ismail, S. B., Noor, N. M., Hussain, N. H. N., Sulaiman, Z., Shamsudin, M. A., & Irfan, M. (2019). Angiotensin Receptor Blockers for Erectile Dysfunction in Hypertensive Men: A Brief Meta-Analysis of Randomized Control Trials. American Journal of Men’s Health, 13(6), 1557988319892735. Doi:10.1177/1557988319892735 google scholar
  • Kessler, A., Sollie, S., Challacombe, B., Briggs, K., & Van Hemelrijck, M. (2019). The global prevalence of erectile dysfunction: a review. British Journal of Urology, doi:10.1111/bju.14813 google scholar
  • Kretchy, I. A., Boima, V., Agyabeng, K., Koduah, A., & Appiah, B. (2020). Psycho-behavioural factors associated with medication adherence among male out-patients with hypertension in a Ghanaian hospital. PLoS One, 15(1), e0227874-e0227874. doi:10.1371/ journal.pone.0227874 google scholar
  • Krüger, T. H., Haake, P., Chereath, D., Knapp, W., Janssen, O. E., Exton, M. S., . . . Hartmann, U. (2003). Specificity of the neuroendocrine response to orgasm during sexual arousal in men. Journal of Endocrinology, 177(1), 57-64. doi:10.1677/joe.0.1770057 google scholar
  • Motofei, I. G., & Rowland, D. L. (2005). The physiological basis of human sexual arousal: neuroendocrine sexual asymmetry. International Journal of Andrology, 28(2), 78-87. doi:10.1111/j.1365-2605.2004.00514.x google scholar
  • Lewis, R. W., Fugl-Meyer, K. S., Corona, G., Hayes, R. D., Laumann, E. O., Moreira, E. D., Jr., . . . Segraves, T. (2010). Definitions/epidemiol-ogy/risk factors for sexual dysfunction. The Journal of Sexual Medicine, 7(4 Pt 2), 1598-1607. doi:10.1111/j.1743-6109.2010.01778.x Nicolai, M. P., Liem, S. S., Both, S., Pelger, R. C., Putter, H., Schalij, M. J., &Elzevier, H. W. (2014). A review of the positive and negative effects of cardiovascular drugs on sexual function: a proposed table for use in clinical practice. Netherlands Heart Journal, 22(1), 11-19. doi:10.1007/s12471-013-0482-z google scholar
  • Nilsson, P. M., Viigimaa, M., Giwercman, A., &Cifkova, R. (2020). Hypertension and Reproduction. Current Hypertension Reports, 22(4), 29. doi:10.1007/s11906-020-01036-2 google scholar
  • Oshodi, O. Y., Adeyemi, J. D., Oke, D. A., & Seedat, S. (2010). Sexual dysfunction among subjects with hypertension in a Nigerian teaching hospital. Nigerian Quarterly Journal of Hospital Medicine, 20(4), 197-204 google scholar
  • Oyelade, B. O., Jemilohun, A. C., &Aderibigbe, S. A. (2016). Prevalence of erectile dysfunction and possible risk factors among men of South-Western Nigeria: a population based study. The Pan African Medical Journal, 24, 124. doi:10.11604/pamj.2016.24.124.8660 Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997). The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology, 49(6), 822-830. doi:10.1016/s0090-4295(97)00238-0 Santi, D., Granata, A. R., Guidi, A., Pignatti, E., Trenti, T., Roli, L., . . . Simoni, M. (2016). Six months of daily treatment with varde-nafil improves parameters of endothelial inflammation and of hypogonadism in male patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, prospective trial. European Journal of Endocrinology, 174(4), 513-522. doi:10.1530/ eje-15-1100 google scholar
  • Spatz, E. S., Canavan, M. E., Desai, M. M., Krumholz, H. M., & Lindau, S. T. (2013). Sexual activity and function among middle-aged and older men and women with hypertension. Journal of Hypertension, 31(6), 1096-1105. doi:10.1097/HJH.0b013e32835fdefa google scholar
  • Viigimaa, M., Vlachopoulos, C., Doumas, M., Wolf, J., Imprialos, K., Terentes-Printzios, D., . . . Mancia, G. (2020). Update of the position paper on arterial hypertension and erectile dysfunction. Journal of Hypertension, 38(7), 1220-1234. doi:10.1097/ hjh.0000000000002382 google scholar

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APA

Akinyede, A.A., Olusanya, A., Mohammed, H.O., Fasipe, O.J., & Arikawe, A. (2022). A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men. İstanbul Journal of Pharmacy, 52(3), 324-331. https://doi.org/10.26650/IstanbulJPharm.2022.975375


AMA

Akinyede A A, Olusanya A, Mohammed H O, Fasipe O J, Arikawe A. A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men. İstanbul Journal of Pharmacy. 2022;52(3):324-331. https://doi.org/10.26650/IstanbulJPharm.2022.975375


ABNT

Akinyede, A.A.; Olusanya, A.; Mohammed, H.O.; Fasipe, O.J.; Arikawe, A. A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 3, p. 324-331, 2022.


Chicago: Author-Date Style

Akinyede, Akinwumi Akinyinka, and Adedunni Olusanya and Hazees Olawale Mohammed and Olumuyiwa John Fasipe and Adesina Arikawe. 2022. “A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men.” İstanbul Journal of Pharmacy 52, no. 3: 324-331. https://doi.org/10.26650/IstanbulJPharm.2022.975375


Chicago: Humanities Style

Akinyede, Akinwumi Akinyinka, and Adedunni Olusanya and Hazees Olawale Mohammed and Olumuyiwa John Fasipe and Adesina Arikawe. “A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men.” İstanbul Journal of Pharmacy 52, no. 3 (Jun. 2023): 324-331. https://doi.org/10.26650/IstanbulJPharm.2022.975375


Harvard: Australian Style

Akinyede, AA & Olusanya, A & Mohammed, HO & Fasipe, OJ & Arikawe, A 2022, 'A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men', İstanbul Journal of Pharmacy, vol. 52, no. 3, pp. 324-331, viewed 9 Jun. 2023, https://doi.org/10.26650/IstanbulJPharm.2022.975375


Harvard: Author-Date Style

Akinyede, A.A. and Olusanya, A. and Mohammed, H.O. and Fasipe, O.J. and Arikawe, A. (2022) ‘A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men’, İstanbul Journal of Pharmacy, 52(3), pp. 324-331. https://doi.org/10.26650/IstanbulJPharm.2022.975375 (9 Jun. 2023).


MLA

Akinyede, Akinwumi Akinyinka, and Adedunni Olusanya and Hazees Olawale Mohammed and Olumuyiwa John Fasipe and Adesina Arikawe. “A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men.” İstanbul Journal of Pharmacy, vol. 52, no. 3, 2022, pp. 324-331. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2022.975375


Vancouver

Akinyede AA, Olusanya A, Mohammed HO, Fasipe OJ, Arikawe A. A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men. İstanbul Journal of Pharmacy [Internet]. 9 Jun. 2023 [cited 9 Jun. 2023];52(3):324-331. Available from: https://doi.org/10.26650/IstanbulJPharm.2022.975375 doi: 10.26650/IstanbulJPharm.2022.975375


ISNAD

Akinyede, AkinwumiAkinyinka - Olusanya, Adedunni - Mohammed, HazeesOlawale - Fasipe, OlumuyiwaJohn - Arikawe, Adesina. “A comparative cross-sectional study investigating prevalence and patterns of sexual dysfunction among hypertensive and non-hypertensive men”. İstanbul Journal of Pharmacy 52/3 (Jun. 2023): 324-331. https://doi.org/10.26650/IstanbulJPharm.2022.975375



ZAMAN ÇİZELGESİ


Gönderim28.07.2021
Kabul12.06.2022
Çevrimiçi Yayınlanma30.12.2022

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