DOI :10.26650/IstanbulJPharm.2022.913936   IUP :10.26650/IstanbulJPharm.2022.913936    Tam Metin (PDF)

A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?

Hazal EkenNurcan Bektaş TürkmenRana Arslan

Pain is sensed by the activation of painful nociceptors in the periphery or by pain mediators, such as bradykinin, serotonin, histamine, and prostaglandin, released from the damaged tissue, afferent transmission to the medulla spinalis, and by transmission stages to the high centers over the dorsal horn. Pain, which was seen as only a warning sign in the past, is now accepted as a phenomenon in itself that needs to be treated and the search for new, stronger active substances with fewer side effects in the treatment of pain is in demand. Hydrogen sulfide (H2S) is a modulator of T-type Ca+2 channels, especially in Cav3.2, which are known to play a critical role in the processing of pain. H2S can also show an anti-nociceptive effect by opening K+ channels and blocking nociceptors. Exciting preclinical data has demonstrated that H2S-derived Non-steroidal antiinflammatory drugs (NSAIDs) and analgesic agents can be used to treat various types of pain. H2S increases the resistance of gastric mucosa against injury occurred by drugs used for pain relief and accelerates its repair, so it provides an advantage to derivatized drugs. In addition, H2S donors have also been shown to induce analgesia through μ-opioid receptors. Based on the studies, it is thought that the combination of H2S with opioid receptor agonists may provide an additive or even synergistic analgesic effect. It is estimated that the modification of H2S, with currently used analgesic drugs to prevent various side effects and increase analgesic effects, is a promising and wise approach.

Anahtar Kelimeler: Hydrogen sulfidePainAnalgesic effect

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Eken, H., Bektaş Türkmen, N., & Arslan, R. (2022). A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?. İstanbul Journal of Pharmacy, 52(1), 101-107.


Eken H, Bektaş Türkmen N, Arslan R. A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?. İstanbul Journal of Pharmacy. 2022;52(1):101-107.


Eken, H.; Bektaş Türkmen, N.; Arslan, R. A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 1, p. 101-107, 2022.

Chicago: Author-Date Style

Eken, Hazal, and Nurcan Bektaş Türkmen and Rana Arslan. 2022. “A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?.” İstanbul Journal of Pharmacy 52, no. 1: 101-107.

Chicago: Humanities Style

Eken, Hazal, and Nurcan Bektaş Türkmen and Rana Arslan. A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?.” İstanbul Journal of Pharmacy 52, no. 1 (Dec. 2023): 101-107.

Harvard: Australian Style

Eken, H & Bektaş Türkmen, N & Arslan, R 2022, 'A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?', İstanbul Journal of Pharmacy, vol. 52, no. 1, pp. 101-107, viewed 5 Dec. 2023,

Harvard: Author-Date Style

Eken, H. and Bektaş Türkmen, N. and Arslan, R. (2022) ‘A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?’, İstanbul Journal of Pharmacy, 52(1), pp. 101-107. (5 Dec. 2023).


Eken, Hazal, and Nurcan Bektaş Türkmen and Rana Arslan. A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?.” İstanbul Journal of Pharmacy, vol. 52, no. 1, 2022, pp. 101-107. [Database Container],


Eken H, Bektaş Türkmen N, Arslan R. A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?. İstanbul Journal of Pharmacy [Internet]. 5 Dec. 2023 [cited 5 Dec. 2023];52(1):101-107. Available from: doi: 10.26650/IstanbulJPharm.2022.913936


Eken, Hazal - Bektaş Türkmen, Nurcan - Arslan, Rana. A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?”. İstanbul Journal of Pharmacy 52/1 (Dec. 2023): 101-107.


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