DOI :10.26650/IstanbulJPharm.2022.890376   IUP :10.26650/IstanbulJPharm.2022.890376    Tam Metin (PDF)

A smarter, tactical approach for combating Covid-19

Gamze ÇamlıkYıldız Özsoy Erginerİsmail Tuncer Değim

As human beings, we communicate with each other just like other creatures. In the same way we need to communicate, COVID-19 has to communicate with other viruses. Following the latest Pandemic, combating COVID-19 has become a major need today. Several theories are being formulated and tested for the efficient prevention and treatment of the virus. Vaccination is the ultimate solution but access to the vaccine and getting vaccinated is limited. The purpose of this review paper is to present a new approach. This approach is based on the Quorum sensing of viruses like bacteria. Bacteria use this for communication and it has recently been proven for viruses too. It can be used as a new way or strategy to stop viral communication, therefore restricting the viral spread will possibly help people around the world or reduce the disease’s side effects. This new tactic involves the use of functionalized Quantum dots nanoparticles, and when they are coupled with carbon atoms and put to use in different delivery forms, these will be useful for maximum efficacy. The use of carbon quantum dots can be useful to minimize certain possible toxic effects. This may be greatly enhanced by doping boron atoms to the structure to trigger their synergistic effects. We suggest here that the inhaler form of this proposed drug delivery system should simultaneously provide a fairly high efficiency and a less toxic solution.

PDF Görünüm


  • Arumugam, S. S., & Malaichamy, I. (2015). Comprehensive mul-tispectroscopic analysis on the interaction and corona formation of human serum albumin with gold/silver alloy nanoparticles. Journal of Physical Chemistry B, 119, 9461-9476. https://doi. org/10.1021/acs.jpcb.5b00436 google scholar
  • Bi, J., Li, Y., Wang, H., Song, Y., Cong, S., Yu, C., Zhu, B. W., & Tan, M. (2017). Presence and formation mechanism of foodborne carbonaceous nanostructures from roasted pike eel (Muraenesox ci-nereus). Journal of Agricultural and Food Chemistry, 66, 2862-2869. google scholar
  • Bourlinos, A. B., Trivizas, G., Karakassides, M. A., Baikousi, M., Kou-loumpis, A., Gournis, D., Bakandritsos, A., Hola, K., Kozak, O., Zbo-ril, R., Papagiannouli, I., Aloukos, P., & Couris, S. (2015). Green and simple route toward boron doped carbon dots with significantly enhanced non-linear optical properties. Carbon, 83, 173-179. google scholar
  • Carnes, E. C., Lopez, D. M., Donegan, N. P., Cheung, A., Gresham, H., & Timmins, G.S. (2010). Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria. Nature Chemical Biology, 6(1), 41-45. google scholar
  • Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2017). Plasma protein adsorption and biological identity of systemically administered nanoparticles. Nanomedicine, 12, 2113-2135. https://doi. org/10.2217/nnm-2017-0178 google scholar
  • Chen, D., Ganesh, S., Wang, W., & Amiji, M. M. (2019). Role of surface chemistry on serum protein corona-mediated cellular delivery and gene silencing with lipid nanoparticles. Nanoscale, 11, 8760-8775. google scholar
  • Degim, I.T. & Kadioglu, D. (2013). Cheap, Suitable, Predictable and Manageable Nanoparticles for Drug Delivery: Quantum Dots, Current Drug Delivery, 10(1), 32-38. google scholar
  • Dietrich, L. E., Price-Whelan, A., Petersen, A., Whiteley, M., & Newman, D. K. (2006). The phenazine pyocyanin is a terminal signaling factor in the quorum sensing network of Pseudomonas aeruginosa. Molecular Microbiology, 61(5), 1308-1321. https://doi. org/10.1111/j.1365-2958.2006.05306.x google scholar
  • Dolgin, E. (2019). The secret social lives of viruses. Nature, 570(7761), 290-292. google scholar
  • Duncan, T. V. (2011). The communication challenges presented by nanofoods. Nature Nanotechnology, 6, 683-688. google scholar
  • Erez, Z., Steinberger-Levy, I., Shamir, M., Doron, S., Stokar-Avihail, A., Peleg, Y., Melamed, S., Leavitt, A., Savidor, A., Albeck, S., Amita, G. & Sorek, R. (2017). Nature, 541, 488-493. nature21049 google scholar
  • Ghaderi, S., Ramesh, B. & Seifalian, A.M. (2011). Fluorescence nanoparticles “quantum dots” as drug delivery system and their toxicity: a review. Journal of Drug Targeting, 19(7), 475-486. google scholar
  • Girma, W.M., Fahmi, M.Z., Permadi, A., Abate, M.A. & Chang, J.Y (2017). Synthetic strategies and biomedical applications of I-III-VI ternary quantum dots. Journal of Materials Chemistry, 5(31), 61936216. google scholar
  • Hu, W., Peng, C., Lv, M., Li, X., Zhang, Y., Chen, N., Fan, C. & Huang, Q. (2011). Protein corona-mediated mitigation of cytotoxicity of graphene oxide. ACS Nano, 5(5), 3693-3700. nn200021j google scholar
  • Huang, R., Carney, R. P., Ikuma, K., Stellacci, F. & Lau, B. L. T. (2014). Effects of surface compositional and structural heterogeneity on nanoparticle protein interactions: Different protein configurations. ACS Nano, 8(6), 5402-5412. google scholar
  • Jiang, Q., Chen, J., Yang, C., Yin, Y. & Yao, K. (2019). Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases. BioMed Research International, 7, 1-15. https://doi. org/10.1155/2019/2015978 google scholar
  • Kandasamy, G. (2019). Recent Advancements in Doped/Co-Doped Carbon Quantum Dots for Multi-Potential Applications. Journal of Carbon Research, 5, 24-42. google scholar
  • Kirtley, M. (2020, May). What is the size of the Covid-19 virus [Web log post]. Retrieved from google scholar
  • Li, Z. & Knetsch, M. (2018). Antibacterial strategies for wound dressing: preventing infection and stimulating healing. Current Pharmaceutical Design, 24(8), 936-951. https://doi.Org/10.2174/1 381612824666180213141109 google scholar
  • Lim, S.Y., Shen, W. & Gao, Z. (2014). Carbon quantum dots and their applications. The Royal Society of Chemistry, 44, 362-381. google scholar
  • Loczechin, A., Séron, K., Barras, A., Giovanelli, E., Belouzard, S., Chen, Y., Metzler-Nolte, N., Boukherroub, R. & Dubuisson, J. (2019). Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus. ACS Applied Materials & Interfaces, 11(46), 42964-42974. google scholar
  • Martin,, L., Johannes, S., Tommy, C., Tord, B. R., Flanagan, M. B., Iseult,, L., Giuliano, E. & Kenneth, D. (2011). The evolution of the protein corona around nanoparticles: A test study. ACS Nano, 5(9), 7503-7509. google scholar
  • Nayak, P. S., Borah, S. M., Gogoi, H., Asthana, S., Bhatnagar, R., Jha A. N. & Jha, S. (2019). Lactoferrin adsorption onto silver nanoparticle interface: Implications of corona on protein conformation, nanoparticle cytotoxicity and the formulation adju-vanticity. Chemical Engineering Journal, 361, 470-484. https://doi. org/10.1016/j.cej.2018.12.084 google scholar
  • Pearson, J. P., Pesci, E. C. & Iglewski, B. H. (1997). Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. Journal of Bacteriology, 179(18), 5756-5767. /10.1128/ jb.179.18.5756-5767.1997 google scholar
  • Shivaji, K., Mani, S., Ponmurugan, P., Castro, C.S., Davies, M.L., Bala-subramanian M.G. & Pitchaimuthu S. (2018). Green-Synthesis-Derived CdS Quantum Dots Using Tea Leaf Extract: Antimicrobial, Bioimaging, and Therapeutic Application in Lung Cancer Cells. ACS Applied.Nano Materials, 1(4), 1683-1693. https://doi. org/10.1021/acsanm.8b00147 google scholar
  • Song, Y., Wu,, Y., Wang, H., Liu, S., Song, L., Li, S. & Tan, M. (2019). Carbon quantum dots from roasted Atlantic salmon (Salmo salar L.): Formation, biodistribution and cytotoxicity. Food Chemistry, 293, 387-395. google scholar
  • Song, Y., Wu, Y., Wang, H., Liu,, S., Song, L., Li, S. & Tan, M. (2020). Protein corona formation of human serum albumin with carbon quantum dots from roasted salmon. Food & Function, 11(3), 23582367. google scholar
  • Turner, P E. & Chao, L. (1999). Nature, 398, 441-443. Retrieved from google scholar
  • Van Delden, C., Pesci, E. C., Pearson, J. P., & Iglewski, B. H. (1998). Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant. Infection and Immunity, 66(9), 4499-4502. IAI.66.9.4499-4502.1998 google scholar
  • Xu, W., Dong, S., Han, Y., Li, S. & Liu, Y. (2018) Hydrogels as antibacterial biomaterials. Current Pharmaceutical Design, 24(8), 843-854. google scholar
  • Yan, Y., Gause, K. T., Kamphuis, M. M. J., Ang, C., O’Brien-Simpson, N. M., Lenzo, J. C., Reynolds, E. C., Nice, E. C. & Frank, C. (2013). Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines. ACS Nano, 7(12), 10960-10970. nn404481f google scholar
  • Yarwood, J. M., Bartels, D. J., Volper, E. M. & Greenberg, E. P. (2004). Quorum sensing in staphylococcus aureus biofilms. Journal of Bacteriology, 186(6), 1838-1850. JB.186.6.1838-1850.2004 google scholar
  • Yi, L., Li, Z., Yuan, K., Qu, X., Chen, J., Wang, G., Zhang, H., Luo, H., Zhu, L., Jiang, P., Chen, L., Shen, Y., Luo, M., Zuo, G., Hu, J., Duan, D., Nie, Y., Shi, X., Wang, W., Han,, Y., Li, T., Liu, Y., Ding, M., Deng, H. & Xu, X. (2004). Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells. Journal of Virology, 78(20), 11334-11339. JVI.78.20.11334-11339.2004 google scholar
  • Zhu, R. R., Wang, W. R., Sun, X. Y., Liu, H. & Wang, S. L. (2010). Enzyme activity inhibition and secondary structure disruption of nano-TiO2 on pepsin. Toxicology in vitro, 24(6), 1639-1647. https:// google scholar


Biçimlendirilmiş bir atıfı kopyalayıp yapıştırın veya seçtiğiniz biçimde dışa aktarmak için seçeneklerden birini kullanın



Çamlık, G., Özsoy Erginer, Y., & Değim, İ.T. (2022). A smarter, tactical approach for combating Covid-19. İstanbul Journal of Pharmacy, 52(3), 357-361.


Çamlık G, Özsoy Erginer Y, Değim İ T. A smarter, tactical approach for combating Covid-19. İstanbul Journal of Pharmacy. 2022;52(3):357-361.


Çamlık, G.; Özsoy Erginer, Y.; Değim, İ.T. A smarter, tactical approach for combating Covid-19. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 3, p. 357-361, 2022.

Chicago: Author-Date Style

Çamlık, Gamze, and Yıldız Özsoy Erginer and İsmail Tuncer Değim. 2022. “A smarter, tactical approach for combating Covid-19.” İstanbul Journal of Pharmacy 52, no. 3: 357-361.

Chicago: Humanities Style

Çamlık, Gamze, and Yıldız Özsoy Erginer and İsmail Tuncer Değim. A smarter, tactical approach for combating Covid-19.” İstanbul Journal of Pharmacy 52, no. 3 (Jun. 2023): 357-361.

Harvard: Australian Style

Çamlık, G & Özsoy Erginer, Y & Değim, İT 2022, 'A smarter, tactical approach for combating Covid-19', İstanbul Journal of Pharmacy, vol. 52, no. 3, pp. 357-361, viewed 9 Jun. 2023,

Harvard: Author-Date Style

Çamlık, G. and Özsoy Erginer, Y. and Değim, İ.T. (2022) ‘A smarter, tactical approach for combating Covid-19’, İstanbul Journal of Pharmacy, 52(3), pp. 357-361. (9 Jun. 2023).


Çamlık, Gamze, and Yıldız Özsoy Erginer and İsmail Tuncer Değim. A smarter, tactical approach for combating Covid-19.” İstanbul Journal of Pharmacy, vol. 52, no. 3, 2022, pp. 357-361. [Database Container],


Çamlık G, Özsoy Erginer Y, Değim İT. A smarter, tactical approach for combating Covid-19. İstanbul Journal of Pharmacy [Internet]. 9 Jun. 2023 [cited 9 Jun. 2023];52(3):357-361. Available from: doi: 10.26650/IstanbulJPharm.2022.890376


Çamlık, Gamze - Özsoy Erginer, Yıldız - Değim, İsmailTuncer. A smarter, tactical approach for combating Covid-19”. İstanbul Journal of Pharmacy 52/3 (Jun. 2023): 357-361.


Çevrimiçi Yayınlanma30.12.2022


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.