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DOI :10.26650/IstanbulJPharm.2022.959603   IUP :10.26650/IstanbulJPharm.2022.959603    Tam Metin (PDF)

An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats

Asha ThomasSeema KambleSohan ChitlangeArchana K. Thikekar

Background and Aims: Tinospora cordifolia (Willd.) Miers (TC), from the Menispermaceae family, is a well-known traditional herb used to treat diabetes mellitus and a variety of other ailments, according to traditional Indian literature. Herbal treatments are commonly used as alternatives to medicines. Anti-diabetic herbal medicines containing TC are available in the market. TC has been identified as a powerful CYP2C9 inhibitor, boosting the risk of herb-drug interactions (HDI) when used with medications metabolized via the CYP pathway. The present study evaluated the pharmacokinetic HDI of TC extract with Gliclazide (GL) after oral co-administration in Wistar rats using in vivo pharmacokinetic studies. Methods: A simple, sensitive & accurate RP-HPLC/PDA method was developed and validated. Chromatographic separations were performed on a C18 analytical column with a mobile phase of acetonitrile and 40 mM ammonium acetate buffer (55:45 v/v) pH 3.0 and flow rate gradient programming. The drug concentrations in plasma were measured using the RP-HPLC method after oral co-administration of TC extract (100 mg/kg) with GL (8.3 mg/kg) in Wistar rats. Results: The pharmacokinetic (PK) interaction studies showed that the bioavailability of GL had significantly increased, with a significant influence on Cmax, AUC0-48, and suppression of volume of distribution (Vd), with no change in Tmax. Conclusion: The results obtained from this in vivo study proposed that there is a potentially significant PK HDI when GL and TC extract are administered together. This knowledge of potential HDI could be beneficial to healthcare providers and diabetic patients on GL medication. Further research is needed to anticipate this pharmacokinetics HDI of GL in humans.


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DIŞA AKTAR



APA

Thomas, A., Kamble, S., Chitlange, S., & Thikekar, A.K. (2022). An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats. İstanbul Journal of Pharmacy, 52(1), 31-36. https://doi.org/10.26650/IstanbulJPharm.2022.959603


AMA

Thomas A, Kamble S, Chitlange S, Thikekar A K. An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats. İstanbul Journal of Pharmacy. 2022;52(1):31-36. https://doi.org/10.26650/IstanbulJPharm.2022.959603


ABNT

Thomas, A.; Kamble, S.; Chitlange, S.; Thikekar, A.K. An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 1, p. 31-36, 2022.


Chicago: Author-Date Style

Thomas, Asha, and Seema Kamble and Sohan Chitlange and Archana K. Thikekar. 2022. “An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats.” İstanbul Journal of Pharmacy 52, no. 1: 31-36. https://doi.org/10.26650/IstanbulJPharm.2022.959603


Chicago: Humanities Style

Thomas, Asha, and Seema Kamble and Sohan Chitlange and Archana K. Thikekar. An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats.” İstanbul Journal of Pharmacy 52, no. 1 (Jul. 2022): 31-36. https://doi.org/10.26650/IstanbulJPharm.2022.959603


Harvard: Australian Style

Thomas, A & Kamble, S & Chitlange, S & Thikekar, AK 2022, 'An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats', İstanbul Journal of Pharmacy, vol. 52, no. 1, pp. 31-36, viewed 6 Jul. 2022, https://doi.org/10.26650/IstanbulJPharm.2022.959603


Harvard: Author-Date Style

Thomas, A. and Kamble, S. and Chitlange, S. and Thikekar, A.K. (2022) ‘An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats’, İstanbul Journal of Pharmacy, 52(1), pp. 31-36. https://doi.org/10.26650/IstanbulJPharm.2022.959603 (6 Jul. 2022).


MLA

Thomas, Asha, and Seema Kamble and Sohan Chitlange and Archana K. Thikekar. An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats.” İstanbul Journal of Pharmacy, vol. 52, no. 1, 2022, pp. 31-36. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2022.959603


Vancouver

Thomas A, Kamble S, Chitlange S, Thikekar AK. An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats. İstanbul Journal of Pharmacy [Internet]. 6 Jul. 2022 [cited 6 Jul. 2022];52(1):31-36. Available from: https://doi.org/10.26650/IstanbulJPharm.2022.959603 doi: 10.26650/IstanbulJPharm.2022.959603


ISNAD

Thomas, Asha - Kamble, Seema - Chitlange, Sohan - Thikekar, ArchanaK.. An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats”. İstanbul Journal of Pharmacy 52/1 (Jul. 2022): 31-36. https://doi.org/10.26650/IstanbulJPharm.2022.959603



ZAMAN ÇİZELGESİ


Gönderim30.06.2021
Kabul15.02.2022
Çevrimiçi Yayınlanma28.04.2022

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