Derleme Makalesi

DOI :10.26650/IstanbulJPharm.2023.1329006   IUP :10.26650/IstanbulJPharm.2023.1329006    Tam Metin (PDF)

Antioxidant supplements: Positive or negative actors in orthodontic treatment

Rümeysa Bilici GeçerGül ÖzhanDerya Dursun

Antioxidant supplements are popular and commonly considered healthy benefits such as reducing the risk of disease. It should be noted that their advantages/disadvantages are still unclear. Some research on antioxidants shows that they may reduce the risk of cancer, heart disease, neurodegenerative diseases, and some chronic diseases, and have various health benefits such as a positive effect on bone metabolism by supporting bone regeneration. Some of them show that the benefits of antioxidant supplements are not clear and indicate to increase the risk. The effects of antioxidants on orthodontic treatment are now being studied extensively due to their widespread use. Antioxidants that regulate bone modulation can be used to reduce orthodontic treatment time, accelerate tooth movement, or in some cases prevent unwanted tooth movement, but their unconscious use can adversely affect the orthodontic treatment. Understanding the mechanisms of action of antioxidants and their effects on orthodontic treatment can increase the success of treatment and prevent adverse situations that may occur due to the use of antioxidants. Many inflammatory mediators play a role in the response to mechanical forces in orthodontic treatment. Increased expression of pro-inflammatory cytokines is associated with oxidative stress. Antioxidants can affect remodeling processes in which osteoblast and osteoclast cells play a role, such as relapse, anchorage, and bone formation after maxillary expansion in orthodontic treatment. The use of antioxidants in orthodontic treatment may increase tooth movement and shorten retention time by increasing osteoblastic activity after maxillary expansion, or on the contrary, slow tooth movement and prolong treatment time by reducing oxidative stress and inflammation. Accordingly, factors such as the desired effect in orthodontic treatment and the phase of treatment should be considered when using antioxidants. We aimed to provide information and suggestions for evaluating the effectiveness of antioxidant use in orthodontic treatment with basic information about antioxidants. 

PDF Görünüm


  • Al-Dlaigan, Y. H., Shaw, L., & Smith, A. (2001). Dental erosion in a group of British 14-year-old school children. Part II: Influ-ence of dietary intake. British Dental Journal, 190(5), 258-261. google scholar
  • Arai, C., Nomura, Y., Ishikawa, M., Noda, K., Choi, J. W., Yashiro, Y., . . . Nakamura, Y. (2010). HSPA1A is upregulated in periodontal lig-ament at early stage of tooth movement in rats. Histochemistry and Cell Biology, 134(4), 337-343. google scholar
  • Arenas-Jal, M., Sune-Negre, J. M., & Garcia-Montoya, E. (2020). Coenzyme Q10 supplementation: Efficacy, safety, and formu-lation challenges. Comprehensive Reviews and Food Science Food Safety, 19(2), 574-594. google scholar
  • Asefi, S., Seifi, M., Fard, G. H., & Lotfi, A. (2018). Innovative eval-uation of local injective gel of curcumin on the orthodontic tooth movement in rats. Dental Research Journal (Isfahan), 15(1), 4049. google scholar
  • Bilici Gecer, R. (2023). In Vıvo Investıgatıon of The Effects of Coen-zyme Q10 on Orthodontıc Tooth Movement (Doctoral Thesis). (Not Published) google scholar
  • Boissy, P., Andersen, T. L., Abdallah, B. M., Kassem, M., Plesner, T., & Delaisse, J. M. (2005). Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation. Cancer Research Journal, 65(21), 9943-9952. google scholar
  • Bolat, E. (2014). Histological and Biochemical Evaluation of the Effects of Vitamins C and E on Orthodontic Tooth Movement in Rats (Doctoral thesis). Retrieved from google scholar
  • Bolat, E., Esenlik, E., Oncu, M., Ozgocmen, M., Avunduk, M. C., & Yuksel, O. (2020). Evaluation of the effects of vitamins C and E on experimental orthodontic tooth movement. Journal of Dental Research, Dental Clinics, Dent Prospects, 14(2), 131-137. google scholar
  • Borhanuddin, B., Mohd Fozi, N. F., & Naina Mohamed, I. (2012). Vitamin e and the healing of bone fracture: the current state of evidence. Evidence- Based Complementary and Alternative Medicine, 2012, 684510. google scholar
  • Buczko, P., Knas, M., Grycz, M., Szarmach, I., & Zalewska, A. (2017). Orthodontic treatment modifies the oxidant-antioxidant balance in saliva of clinically healthy subjects. Advances in Medical Sciences, 62(1), 129-135. google scholar
  • Calder, P. C. (2006). n-3 polyunsaturated fatty acids, inflam-mation, and inflammatory diseases. The American Jour-nal of Clinical Nutrition, 83(6 Suppl), 1505S-1519S. google scholar
  • Cesur, M. G., Gulle, K., Sirin, F. B., Akpolat, M., Ogrenim, G., Alkan, A., & Cesur, G. (2018). Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemi-cal, histological and immunohistochemical study. Orthodontics & Craniofacial Research. google scholar
  • Chae, H. S., Park, H. J., Hwang, H. R., Kwon, A., Lim, W. H.,Yi, W. J., . . . Baek, J. H. (2011). The effect of antioxi-dants on the production of pro-inflammatory cytokines and or-thodontic tooth movement. Molecules and Cells, 32(2), 189-196. google scholar
  • Chen, Y. W., Wang, H. C., Gao, L. H., Liu, C., Jiang, Y. X., Qu, H., . . . Jiang, J. H. (2016). Osteoclastogene-sis in Local Alveolar Bone in Early Decortication-Facilitated Orthodontic Tooth Movement. PLoS One, 11(4), e0153937. google scholar
  • Clarke, M. W., Burnett, J. R., & Croft, K. D. (2008). Vitamin E in human health and disease. Crit Rev Clin Lab Sci, 45(5), 417-450. google scholar
  • Colombo, M. L. (2010). An update on vitamin E, tocopherol and tocotrienol-perspectives. Molecules, 15(4), 2103-2113. google scholar
  • Crane, F. L. (2001). Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition, 20(6), 591-598. google scholar
  • Dehis, H., Rahman, A.R.A., Aziz M.A.W.M.A., Yasin, M.M., Yussif, N.M.A. (2018). Efficacy and safety of locally injectable Vitamin C on accelerating the orthodontic movement of maxillary canine im-paction (oral mesotherapy technique): Prospective study. Clinical Cases in Mineral and Bone Metabolism, 15, 280-287. google scholar
  • Demir, M. E. (2020). Evaluatıon of The Effect of Grape Seed Extract on Bone Formatıon in Palatal Sutures of Rats Durıng Rapıd Maxıllary Expansıon (Doctoral thesis). Retrieved from _F5QEpayDXGqGZlp9XiFtJ-OSGgWjuSQRl4R0dB1UQnk1e LOeZvHcV5TqGnfu_4j google scholar
  • EFSA (European Food Safety Authority) (2014). Refined exposure assessment for curcumin (E 100). The EFSA Journal, 12(10), 3876. Retrieved from http:// google scholar
  • Esenlik, E., Naziroglu, M., Acikalin, C., & Ovey, I. S. (2012). Vitamin E supplementation modulates gingival crevicular fluid lipid peroxidation and antioxidant levels in patients with orthodontic tooth movement. Cell Biochemistry & Function, 30(5), 376-381. google scholar
  • Fan, L., Feng, Y., Chen, G. C., Qin, L. Q., Fu, C. L., & Chen, L. H. (2017). Effects of coenzyme Q10 supplementation on inflam-matory markers: A systematic review and meta-analysis of ran-domized controlled trials. Pharmacology Research, 119, 128-136. google scholar
  • Farhadian, N., Miresmaeili, A., Azar, R., Zargaran, M., Moghimbeigi, A., & Soheilifar, S. (2015). Effect of dietary ascorbic Acid on osteogenesis of expanding midpalatal suture in rats. Joural of Dental Medicine (Tehran), 12(1), 39-48. google scholar
  • Fujita, I., Hirano, J., Itoh, N., Nakanishi, T., & Tanaka, K. (2001). Dexamethasone induces sodium-dependant vitamin C transporter in a mouse osteoblastic cell line MC3T3-E1. British Journal of Nutrition, 86(2), 145-149. google scholar
  • Gad, A. M., & Soliman, S. O. (2023). Evaluation of systemic Omega-3 PUFAs effect on orthodontic tooth movement in a rabbit model: RCT. The Angle Orthodontist, 93(4), 476-481. google scholar
  • Gregory, J. F., 3rd. (1993). Ascorbic acid bioavailability in foods and supplements. Nutrition Reviews, 51(10), 301-303. google scholar
  • Hamidi, M. S., Corey, P. N., & Cheung, A. M. (2012). Effects of vitamin E on bone turnover markers among US postmenopausal women. Journal of Bone and Mineral Research, 27(6), 1368-1380. google scholar
  • Hargreaves, I. R., & Mantle, D. (2021). COVID-19, Coenzyme Q10 and Selenium. Advances in Experimental Medicine and Biology, 1327, 161-168. google scholar
  • Herrera, E., & Barbas, C. (2001). Vitamin E: action, metabolism and perspectives. Journal of Physiology and Biochemistry, 57(2), 4356. google scholar
  • Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: A Review of Its Effects on Human Health. Foods, 6(10). google scholar
  • Huang, C. H., Chang, R. J., Huang, S. L., & Chen, W. (2003). Dietary vitamin E supplementation affects tissue lipid perox-idation of hybrid tilapia, Oreochromis niloticus x O. aureus. Comparative Biochemistry and Physiology B, 134(2), 265-270. google scholar
  • Ishikawa, S., Iwasaki, K., Komaki, M., & Ishikawa, I. (2004). Role of ascorbic acid in periodontal ligament cell dif-ferentiation. Journal of Periodontology, 75(5), 709-716. google scholar
  • Iwami-Morimoto, Y., Yamaguchi, K., & Tanne, K. (1999). Influ-ence of dietary n-3 polyunsaturated fatty acid on experimental tooth movement in rats. The Angle Orthodontist, 69(4), 365-371. (1999)069<0365:IOD-NPF>2.3.CO;2 google scholar
  • Jacob, R. A., & Sotoudeh, G. (2002). Vitamin C function and sta-tus in chronic disease. Nutrition in Clinical Care, 5(2), 66-74. doi:10.1046/j.1523-5408.2002.00005.x google scholar
  • Jager, A., & Radlanski, R. J. (1991). Alveolar bone remodelling fol-lowing orthodontic tooth movement in aged rats. An animal ex-perimental study. Deutsche Stomatologie, 41, 399-406. google scholar
  • Jiang, Q. (2014). Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease preven-tion and therapy. Free Radical Biology and Medicine, 72, 76-90. google scholar
  • Jiang, Y., Luo, W., Wang, B., Wang, X., Gong, P., & Xiong, Y. (2020). Resveratrol promotes osteogenesis via activating SIRT1/FoxO1 pathway in osteoporosis mice. Life Sciences Journal, 246, 117422. google scholar
  • Kabasawa, M., Ejiri, S., Hanada, K., Ozawa, H. (1996). Effect of age on physiologic and mechanically stressed rat alveolar bone: a cytologic and histochemical study. The International Journal of Adult Orthodontics & Orthognathic Surgery, 11, 313-327. google scholar
  • Kacprzak, A., & Strzecki, A. (2018). Methods of accelerat-ing orthodontic tooth movement: A review of contempo-rary literature. Dental and Medical Problems, 55(2), 197-206. google scholar
  • Kara, M.I., Erciyas, K., Altan, A.B., Ozkurt, M., Ay, S., & İnan, S. (2012). Thymoquinone accelerates new bone formation in the rapid maxillary expansion procedure. Archieves of Oral Biology, 57, 357-363. google scholar
  • Kale, S., Kocadereli, I., Atilla, P., & Asan, E. (2004). Com-parison of the effects of 1,25 dihydroxycholecalciferol and prostaglandin E2 on orthodontic tooth movement. American Jour-nal of Orthodontics and Dentofacial Orthopedics, 125(5), 607614. google scholar
  • Kawamukai, M. (2002). Biosynthesis, bioproduction and novel roles of ubiquinone. Journal of Bioscience Bioengineering, 94(6), 511517. google scholar
  • Kazmierczak-Baranska, J., Boguszewska, K., Adamus-Grabicka, A., & Karwowski, B. T. (2020). Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent. Nutrients, 12(5). google scholar
  • Krupa, K., Fritzy, K., & Parmar M. (2023, Jan 17). Omega-3 Fatty Acids. In: StatPearls [Web Book] Retrieved from google scholar
  • Kurklu, M., Yildiz, C., Kose, O., Yurttas, Y., Karacalioglu, O., Serdar, M., & Deveci, S. (2011). Effect of alpha-tocopherol on bone formation during distraction osteogenesis: a rabbit model. Journal of Orthopaedics and Traumatology, 12(3), 153-158. google scholar
  • Li, X., Li, M., Lu, J., Hu, Y., Cui, L., Zhang, D., & Yang, Y. (2016) Age-related effects on osteoclastic activities after orthodontic tooth movement. Bone and Joint Research. 5(10), 492-499. google scholar
  • Litton, S. F. (1974). Orthodontic tooth movement during an ascorbic acid deficiency. American Journal of Or-thodontics and Dentofacial Orthopedics, 65(3), 290-302. google scholar
  • Liu, X. C., Wang, X. X., Zhang, L. N., Yang, F., Nie, F. J., & Zhang, J. (2020). Inhibitory effects of resvera-trol on orthodontic tooth movement and associated root re-sorption in rats. Archives of Oral Biology, 111, 104642. google scholar
  • Lopez-Lluch, G., Rodriguez-Aguilera, J. C., Santos-Ocana, C., & Navas, P. (2010). Is coenzyme Q a key factor in aging? Mechanisms of Ageing and Development, 131(4), 225-235. google scholar
  • Madian A.M., A. E. M., Haruni N.M., Abdelmajeed S. (2021). The Effect Of Systemic Administration Of Co-Enzyme Q10 On Or-thodontic Relapse In A Rabbıt Model. Alexandria Dental Journal, 46, 197-204. google scholar
  • Malhotra, S., Sawhney, G., & Pandhi, P. (2004). The therapeutic poten-tial of melatonin: a review of the science. Medscape Gen Medicine, 6(2), 46. google scholar
  • Mangels, A. R., Block, G., Frey, C. M., Patterson, B. H., Taylor, P. R., Norkus, E. P., & Levander, O. A. (1993). The bioavailability to humans of ascorbic acid from oranges, or-ange juice and cooked broccoli is similar to that of synthetic ascorbic acid. The Journal of Nutrition, 123(6), 1054-1061. google scholar
  • Masella, R. S., & Meister, M. (2006). Current concepts in the biology of orthodontic tooth movement. American Journal of Orthodontics and Dentofacial Orthopedics, 129(4), 458-468. google scholar
  • Mata-Granados, J. M., Cuenca-Acebedo, R., Luque de Castro, M. D., & Quesada Gomez, J. M. (2013). Lower vitamin E serum levels are associated with osteoporosis in early postmenopausal women: a cross-sectional study. Journal of Bone and Mineral Metabolism, 31(4), 455-460. google scholar
  • Miresmaeili, A., Mollaei, N., Azar, R., Farhadian, N., & Mani Kashani, K. (2015). Effect of Dietary Vitamin C on Orthodontic Tooth Movement in Rats. Journal of Dental Medicine (Tehran), 12(6), 409-413. google scholar
  • Mironczuk-Chodakowska, I., Witkowska, A. M., & Zujko, M. E. (2018). Endogenous non-enzymatic antioxidants in the human body. Advances in Medical Sciences, 63(1), 68-78. google scholar
  • Monsen, E. R. (2000). Dietary reference intakes for the antioxi-dant nutrients: vitamin C, vitamin E, selenium, and carotenoids. Journal of American Dietetic Association, 100(6), 637-640. google scholar
  • Mori, T. A., & Beilin, L. J. (2004). Omega-3 fatty acids and inflammation. Current Atherosclerosis Reports, 6(6), 461-467. google scholar
  • Motoji, H., To, M., Hidaka, K., & Matsuo, M. (2020). Vitamin C and eggshell membrane facilitate orthodontic tooth movement and induce histological changes in the peri-odontal tissue. Journal of Oral Biosciences, 62(1), 80-87. google scholar
  • NIH (2021, March 26). National Institues of Health Office of Dietary Supplements, Vitamin E [Web]. Retrieved from google scholar
  • NIH (2023, Feb 15). National Institues of Health Office of Dietary Supplements, Omega-3 Fatty Acids [Web]. Re-trieved from google scholar
  • Nur Azlina, M. F., & Nafeeza, M. I. (2008). Tocotrienol and alpha-tocopherol reduce corticosterone and noradrenalin levels in rats exposed to restraint stress. Die Pharmazie, 63(12), 890-892. google scholar
  • Ogrenim, G., Cesur, M. G., Onal, T., Kara, M., Sirin, F. B., Yal-cin, G. D., & Inan, S. (2019). Influence of omega-3 fatty acid on orthodontic tooth movement in rats: A biochemi-cal, histological, immunohistochemical and gene expression study. Orthodontics & Craniofacial Research, 22(1), 24-31. google scholar
  • Okubo, N., Ishikawa, H., Sano, R., Shimazu, Y., & Takeda, M. (2020). Effect of resveratrol on the hyperexcitability of nociceptive neu-rons associated with ectopic hyperalgesia induced by experimen-tal tooth movement. European Journal of Oral Sciences, 128(4), 275-283. google scholar
  • Ozdemir, M., Ilhan, A., Gorucu-Coskuner, H., Taner, T., & Bil-gic, P. (2021). Assessment of food consumption changes in adolescents during orthodontic treatment. American Journal of Orthodontics and Dentofacial Orthopedics, 159(5), 604-612. google scholar
  • Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., . . . Bitto, A. (2017). Oxidative Stress: Harms and Benefits for Human Health. Oxidative Medicine and Cellular Longevity, 2017, 8416763. google scholar
  • Ramirez-Garza, S. L., Laveriano-Santos, E. P., Marhuenda-Munoz, M., Storniolo, C. E., Tresserra-Rimbau, A., Vallverdu-Queralt, A., & Lamuela-Raventos, R. M. (2018). Health Effects of Resver-atrol: Results from Human Intervention Trials. Nutrients, 10(12). google scholar
  • Ren, Y., Kuijpers-Jagtman, A. M., & Maltha, J. C. (2005). Immuno-histochemical evaluation of osteoclast recruitment during experi-mental tooth movement in young and adult rats. Archieves of Oral Biology 50, 1032-1039. google scholar
  • Salomao, M. F., Reis, S. R., Vale, V. L., Machado, C. V., Meyer, R., & Nascimento, I. L. (2014). Immunolocalization of FGF-2 and VEGF in rat periodontal ligament during experimental tooth movement. Dental Press Journal of Orthodontics, 19(3), 67-74. google scholar
  • Samita, Verma, S. K., Sharma, V. K., Moinuddin, & Ahad, A. (2022). Effect of 1% curcumin gel on myeloperoxidase activity in GCF and periodontal status in the initial phase of orthodon-tic tooth movement. Journal of Orthodontic Science, 11, 55. google scholar
  • Schroder, A., Alefeld, A., Forneck, A., Spanier, G., Deschner, J., Proff, P., & Kirschneck, C. (2022). Impact of mela-tonin on periodontal ligament fibroblasts during mechanical strain. European Journal of Orthodontics, 44(6), 659-668. google scholar
  • Seong, C., Chen, P. J., Kalajzic, Z., Mehta, S., Sharma, A., Nanda, R., . . . Dutra, E. H. (2022). Vitamin E enriched diet increases the rate of orthodontic tooth movement. American Journal of Or-thodontics and Dentofacial Orthopedics, 161(5), 687-697 e683. google scholar
  • Shi, W. Q., Liu, J., Cao, Y., Zhu, Y. Y., Guan, K., & Chen, Y. M. (2016). Association of dietary and serum vitamin E with bone mineral density in middle-aged and elderly Chinese adults: a cross-sectional study. British Journal of Nutrition, 115(1), 113-120. google scholar
  • Shoji-Matsunaga, A., Ono, T., Hayashi, M., Takayanagi, H., Moriyama, K., & Nakashima, T. (2017). Osteocyte reg-ulation of orthodontic force-mediated tooth movement via RANKL expression. Scientifict Reports, 7(1), 8753. google scholar
  • Sood, B. & Keenaghan, M. (2022, Jan 19). Coenzym Q10. In: StatPearls [Web Book] Retrieved from google scholar
  • Sotler, R., Poljsak, B., Dahmane, R., Jukic, T., Pavan Jukic, D., Rotim, C., . . . Starc, A. (2019). Prooxidant Activities of Antioxidants and Their Impact on Health. Acta Clinica Croatica, 58(4), 726-736. google scholar
  • Sufarnap, E., Ilyas, S., Sofyanti, E., Siregar, D., Lindawati, Y., No-valia, T., & Kurnianingsih, H. (2021). Vitamin E supplementa-tion reduces stress levels from orthodontic force in Wistar rats (Rattus norvegicus). The Saudi Dental Journal, 33(8), 912-916. google scholar
  • Sufarnap, E., Siregar, D., & Lindawati, Y. (2020). Effect of vitamin E supplementation on orthodontic tooth movement in Wistar rats: a prelimary study. F1000Res, 9, 1093. google scholar
  • Sun, D., Krishnan, A., Zaman, K., Lawrence, R., Bhattacharya, A., & Fernandes, G. (2003). Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. Journal of Bone and Mineral Research, 18(7), 1206-1216. google scholar
  • Unlu, A., Nayir, E., Dogukan Kalenderoglu, M., Kirca, O., & Ozdogan, M. (2016). Curcumin (Turmeric) and cancer. Journal of Balkan Union of Oncology, 21(5), 1050-1060. google scholar
  • Uysal, T., Amasyali, M., Olmez, H., Enhos, S., Karslioglu, Y., & Gunhan, O. (2011). Effect of vitamin C on bone for-mation in the expanded inter-premaxillary suture. Early bone changes. Journal of Orofacial Orthopedics, 72(4), 290-300. google scholar
  • Van den Berg, G. J., Yu, S., Lemmens, A. G., & Beynen, A. C. (1994). Dietary ascorbic acid lowers the concentration of soluble copper in the small intestinal lumen of rats. British Journal of Nutrition, 71(5), 701-707. google scholar
  • van Tits, L. J., Demacker, P. N., de Graaf, J., Hak-Lemmers, H. L., & Stalenhoef, A. F. (2000). alpha-tocopherol supplementation de-creases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individu-als. The American Journal of Clinical Nutrition, 71(2), 458-464. google scholar
  • Varela-Lopez, A., Giampieri, F., Battino, M., & Quiles, J. L. (2016). Coenzyme Q and Its Role in the Di-etary Therapy against Aging. Molecules, 21(3), 373. google scholar
  • Verna, C., Zaffe, D., & Siciliani, G. (1999). Histomorphometric study of bone reactions during orthodontic tooth movement in rats. Bone, 24(4), 371-379. google scholar
  • Virtamo, J., Pietinen, P., Huttunen, J. K., Korhonen, P., Malila, N., Virtanen, M. J., . . . Group, A. S. (2003). Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supple-mentation: a postintervention follow-up. JAMA İnternal Medicine, 290(4), 476-485. google scholar
  • Xia, N., Daiber, A., Forstermann, U., & Li, H. (2017). An-tioxidant effects of resveratrol in the cardiovascular sys-tem. British Journal of Pharmacology, 174(12), 1633-1646. google scholar
  • Xu, H., Watkins, B. A., & Seifert, M. F. (1995). Vitamin E stim-ulates trabecular bone formation and alters epiphyseal cartilage morphometry. Calcified Tissue International, 57(4), 293-300. google scholar
  • Yalcin Bahat, P., Ayhan, I., Ureyen Ozdemir, E., Inceboz, U., & Oral, E. (2022). Dietary supplements for treatment of endometriosis: A review. Acta Biomedica, 93(1), e2022159. google scholar
  • Yang, L., Wang, H., Song, S., Xu, H., Chen, Y., Tian, S., . . . Zhang, Q. (2022). Systematic Understanding of Anti-Aging Effect of Coenzyme Q10 on Oocyte Through a Network Pharmacology Approach. Frontiers in Endocrinology (Lausanne), 13, 813772. google scholar
  • Zhang, J., Hu, X., & Zhang, J. (2017). Associations between serum vitamin E concentration and bone mineral density in the US el-derly population. Osteoporosis International, 28(4), 1245-1253. google scholar


Biçimlendirilmiş bir atıfı kopyalayıp yapıştırın veya seçtiğiniz biçimde dışa aktarmak için seçeneklerden birini kullanın



Bilici Geçer, R., Özhan, G., & Dursun, D. (2023). Antioxidant supplements: Positive or negative actors in orthodontic treatment. İstanbul Journal of Pharmacy, 53(3), 358-367.


Bilici Geçer R, Özhan G, Dursun D. Antioxidant supplements: Positive or negative actors in orthodontic treatment. İstanbul Journal of Pharmacy. 2023;53(3):358-367.


Bilici Geçer, R.; Özhan, G.; Dursun, D. Antioxidant supplements: Positive or negative actors in orthodontic treatment. İstanbul Journal of Pharmacy, [Publisher Location], v. 53, n. 3, p. 358-367, 2023.

Chicago: Author-Date Style

Bilici Geçer, Rümeysa, and Gül Özhan and Derya Dursun. 2023. “Antioxidant supplements: Positive or negative actors in orthodontic treatment.” İstanbul Journal of Pharmacy 53, no. 3: 358-367.

Chicago: Humanities Style

Bilici Geçer, Rümeysa, and Gül Özhan and Derya Dursun. Antioxidant supplements: Positive or negative actors in orthodontic treatment.” İstanbul Journal of Pharmacy 53, no. 3 (Mar. 2024): 358-367.

Harvard: Australian Style

Bilici Geçer, R & Özhan, G & Dursun, D 2023, 'Antioxidant supplements: Positive or negative actors in orthodontic treatment', İstanbul Journal of Pharmacy, vol. 53, no. 3, pp. 358-367, viewed 3 Mar. 2024,

Harvard: Author-Date Style

Bilici Geçer, R. and Özhan, G. and Dursun, D. (2023) ‘Antioxidant supplements: Positive or negative actors in orthodontic treatment’, İstanbul Journal of Pharmacy, 53(3), pp. 358-367. (3 Mar. 2024).


Bilici Geçer, Rümeysa, and Gül Özhan and Derya Dursun. Antioxidant supplements: Positive or negative actors in orthodontic treatment.” İstanbul Journal of Pharmacy, vol. 53, no. 3, 2023, pp. 358-367. [Database Container],


Bilici Geçer R, Özhan G, Dursun D. Antioxidant supplements: Positive or negative actors in orthodontic treatment. İstanbul Journal of Pharmacy [Internet]. 3 Mar. 2024 [cited 3 Mar. 2024];53(3):358-367. Available from: doi: 10.26650/IstanbulJPharm.2023.1329006


Bilici Geçer, Rümeysa - Özhan, Gül - Dursun, Derya. Antioxidant supplements: Positive or negative actors in orthodontic treatment”. İstanbul Journal of Pharmacy 53/3 (Mar. 2024): 358-367.


Çevrimiçi Yayınlanma03.10.2023


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.