Araştırma Makalesi

DOI :10.26650/IstanbulJPharm.2022.980682   IUP :10.26650/IstanbulJPharm.2022.980682    Tam Metin (PDF)

Diapin®: A food supplement with diverse therapeutic potentials

Umar Faruk MagajiSelahattin BoyacıUmut BülbülSadettin AkçaÖzlem SaçanRefiye Yanardağ

Background and Aims: For many centuries herbs and spices have traditionally been used to treat or manage a variety of diseases. The formulation of food supplements containing single or multiple herbs or spices is now popular. These formulations provide biochemical, pharmacological and medicinal benefits due to their diverse phytochemical constituents. Methods: In the present study, Diapin® – a food supplement containing Olea europaea L. leaves extract, Cinnamomum cassia (L.) J. Presl stem extract, Nigella sativa L. seed oil, Cocos nucifera L. oil and vitamin D3 – dissolved in absolute ethanol was evaluated for α-amylase, α-glucosidase, acetylcholinesterase, elastase, neuraminidase, adenosine deaminase and arginase inhibitory activity. Results: The supplement strongly inhibited neuraminidase (IC50 = 0.272 ± 0.007 mg/mL), while adenosine deaminase, acetylcholinesterase, elastase and arginase were moderately inhibited (with an IC50 of 4.562 ± 0.052, 5.396 ± 0.563, 5.783 ± 0.058 and 6.800 ± 0.067 mg/mL respectively). The less inhibition activity was on α-amylase and α-glucosidase (IC50 = 9.593 ± 0.582 and 14.010 ± 2.280 mg/mL respectively). Conclusion: The pharmacological activities of Diapin® can be attributed to its opulent phytochemical composition. The present findings support the folkloric claim of Diapin® supplement having antidiabetic, anticancer, anti-inflammatory, antimicrobial, anti-ageing, and immune bolstering properties, in addition to the mitigation of Alzheimer’s disease and the alleviation of neurological dysfunction.

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Biçimlendirilmiş bir atıfı kopyalayıp yapıştırın veya seçtiğiniz biçimde dışa aktarmak için seçeneklerden birini kullanın



Magaji, U.F., Boyacı, S., Bülbül, U., Akça, S., Saçan, Ö., & Yanardağ, R. (2022). Diapin®: A food supplement with diverse therapeutic potentials. İstanbul Journal of Pharmacy, 52(3), 302-310.


Magaji U F, Boyacı S, Bülbül U, Akça S, Saçan Ö, Yanardağ R. Diapin®: A food supplement with diverse therapeutic potentials. İstanbul Journal of Pharmacy. 2022;52(3):302-310.


Magaji, U.F.; Boyacı, S.; Bülbül, U.; Akça, S.; Saçan, Ö.; Yanardağ, R. Diapin®: A food supplement with diverse therapeutic potentials. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 3, p. 302-310, 2022.

Chicago: Author-Date Style

Magaji, Umar Faruk, and Selahattin Boyacı and Umut Bülbül and Sadettin Akça and Özlem Saçan and Refiye Yanardağ. 2022. “Diapin®: A food supplement with diverse therapeutic potentials.” İstanbul Journal of Pharmacy 52, no. 3: 302-310.

Chicago: Humanities Style

Magaji, Umar Faruk, and Selahattin Boyacı and Umut Bülbül and Sadettin Akça and Özlem Saçan and Refiye Yanardağ. Diapin®: A food supplement with diverse therapeutic potentials.” İstanbul Journal of Pharmacy 52, no. 3 (May. 2023): 302-310.

Harvard: Australian Style

Magaji, UF & Boyacı, S & Bülbül, U & Akça, S & Saçan, Ö & Yanardağ, R 2022, 'Diapin®: A food supplement with diverse therapeutic potentials', İstanbul Journal of Pharmacy, vol. 52, no. 3, pp. 302-310, viewed 28 May. 2023,

Harvard: Author-Date Style

Magaji, U.F. and Boyacı, S. and Bülbül, U. and Akça, S. and Saçan, Ö. and Yanardağ, R. (2022) ‘Diapin®: A food supplement with diverse therapeutic potentials’, İstanbul Journal of Pharmacy, 52(3), pp. 302-310. (28 May. 2023).


Magaji, Umar Faruk, and Selahattin Boyacı and Umut Bülbül and Sadettin Akça and Özlem Saçan and Refiye Yanardağ. Diapin®: A food supplement with diverse therapeutic potentials.” İstanbul Journal of Pharmacy, vol. 52, no. 3, 2022, pp. 302-310. [Database Container],


Magaji UF, Boyacı S, Bülbül U, Akça S, Saçan Ö, Yanardağ R. Diapin®: A food supplement with diverse therapeutic potentials. İstanbul Journal of Pharmacy [Internet]. 28 May. 2023 [cited 28 May. 2023];52(3):302-310. Available from: doi: 10.26650/IstanbulJPharm.2022.980682


Magaji, UmarFaruk - Boyacı, Selahattin - Bülbül, Umut - Akça, Sadettin - Saçan, Özlem - Yanardağ, Refiye. Diapin®: A food supplement with diverse therapeutic potentials”. İstanbul Journal of Pharmacy 52/3 (May. 2023): 302-310.


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