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DOI :10.26650/IstanbulJPharm.2023.1166404   IUP :10.26650/IstanbulJPharm.2023.1166404    Tam Metin (PDF)

Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique

Olubunmi Jumoke OlayemiRashida Abdullahi

Background and Aims: Literature reveals many benefits and potentials of the stem bark extract of Prosopis africana but like other plant extracts, its use in the oral pharmaceutical formulation is limited due to its poor aqueous solubility, reduced absorption, and bioavailability. The aim of this study is to develop oral solid dispersion formulations of Prosopis africana extract to improve its dissolution and possible bioavailability.

Methods: Crushed stem bark of Prosopis africana was macerated in methanol for 72 h at room temperature. The resulting extract (PREx) was incorporated into polyethylene glycol 4000 (PEG 4000) by the solvent-evaporation and melt-fusion methods using different ratios (1:1, 1:2, 1:4) of extract to polymer; physical mixtures of the same ratio of extract to polymer were also prepared. The crystallinity of the formulations was characterized by differential scanning calorimetry (DSC), possible interaction/incompatibility between the extract and polymer was determined by Fourier transform infra-red spectroscopy (FT-IR). In vitro, release and modeling of the release profile were also determined.

Results: No interaction was found between materials used for the preparations while DSC thermograms showed a reduction in crystallinity of PREx in the solid dispersion formulations. In vitro release profile of the formulation prepared with the highest polymer concentration by the melt-fusion method (M3) showed the greatest enhancement in dissolution.

Conclusion: This study shows solid dispersion prepared by the melt-fusion method as an effective technique for the enhancement of dissolution of poorly water-soluble Prosopis africana extract.

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Olayemi, O.J., & Abdullahi, R. (2023). Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. İstanbul Journal of Pharmacy, 53(2), 229-238.


Olayemi O J, Abdullahi R. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. İstanbul Journal of Pharmacy. 2023;53(2):229-238.


Olayemi, O.J.; Abdullahi, R. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. İstanbul Journal of Pharmacy, [Publisher Location], v. 53, n. 2, p. 229-238, 2023.

Chicago: Author-Date Style

Olayemi, Olubunmi Jumoke, and Rashida Abdullahi. 2023. “Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique.” İstanbul Journal of Pharmacy 53, no. 2: 229-238.

Chicago: Humanities Style

Olayemi, Olubunmi Jumoke, and Rashida Abdullahi. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique.” İstanbul Journal of Pharmacy 53, no. 2 (Dec. 2023): 229-238.

Harvard: Australian Style

Olayemi, OJ & Abdullahi, R 2023, 'Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique', İstanbul Journal of Pharmacy, vol. 53, no. 2, pp. 229-238, viewed 9 Dec. 2023,

Harvard: Author-Date Style

Olayemi, O.J. and Abdullahi, R. (2023) ‘Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique’, İstanbul Journal of Pharmacy, 53(2), pp. 229-238. (9 Dec. 2023).


Olayemi, Olubunmi Jumoke, and Rashida Abdullahi. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique.” İstanbul Journal of Pharmacy, vol. 53, no. 2, 2023, pp. 229-238. [Database Container],


Olayemi OJ, Abdullahi R. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique. İstanbul Journal of Pharmacy [Internet]. 9 Dec. 2023 [cited 9 Dec. 2023];53(2):229-238. Available from: doi: 10.26650/IstanbulJPharm.2023.1166404


Olayemi, OlubunmiJumoke - Abdullahi, Rashida. Enhancement of dissolution of Prosopis africana stem bark extract by solid dispersion technique”. İstanbul Journal of Pharmacy 53/2 (Dec. 2023): 229-238.


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