Araştırma Makalesi

DOI :10.26650/IstanbulJPharm.2023.1054752   IUP :10.26650/IstanbulJPharm.2023.1054752    Tam Metin (PDF)

Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress

Pelin EroğluDilek EkeSerap YalınAyla ÇelikAli Erdinç Yalın

Background and Aims: The potential effects of perfluorooctane sulfonate (PFOS) on the environment and human health have aroused great concerns in recent years. To our knowledge, there are limited studies related with the effect of curcumin on PFOS induced damage in the literature. The existing studies are focused on DNA damage. No study has been found examining the effect on the antioxidant system. We planned this study to investigate the impact of curcumin on the antioxidant defense system response in rats exposed to PFOS.

Methods: The animals were divided into six groups, with the first group used as control. Groups II to VI were orally treated with curcumin (80 mg/kg), PFOS (1.25 mg/kg), PFOS (1.25 mg/kg) + curcumin, PFOS (2.5 mg/kg), and PFOS (2.5 mg/kg) + curcumin daily for 30 days, respectively. For oxidative stress, liver, kidney, and brain samples were homogenized. The activities of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT) activities, and malondialdehyde (MDA) content were determined. Data from the experiments were statistically analyzed by SPSS 11.0 program.

Results: Our data showed that PFOS increased MDA level, while the activities of SOD and CAT decreased. It was observed that the application of curcumin together with PFOS decreased the MDA level and increased the antioxidant enzyme activities.

Conclusion: As an antioxidant, curcumin plays an important protective role against oxidative damage and inhibits PFOS-induced lipid peroxidation.

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Eroğlu, P., Eke, D., Yalın, S., Çelik, A., & Yalın, A.E. (2023). Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress. İstanbul Journal of Pharmacy, 53(2), 159-165.


Eroğlu P, Eke D, Yalın S, Çelik A, Yalın A E. Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress. İstanbul Journal of Pharmacy. 2023;53(2):159-165.


Eroğlu, P.; Eke, D.; Yalın, S.; Çelik, A.; Yalın, A.E. Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress. İstanbul Journal of Pharmacy, [Publisher Location], v. 53, n. 2, p. 159-165, 2023.

Chicago: Author-Date Style

Eroğlu, Pelin, and Dilek Eke and Serap Yalın and Ayla Çelik and Ali Erdinç Yalın. 2023. “Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress.” İstanbul Journal of Pharmacy 53, no. 2: 159-165.

Chicago: Humanities Style

Eroğlu, Pelin, and Dilek Eke and Serap Yalın and Ayla Çelik and Ali Erdinç Yalın. Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress.” İstanbul Journal of Pharmacy 53, no. 2 (Dec. 2023): 159-165.

Harvard: Australian Style

Eroğlu, P & Eke, D & Yalın, S & Çelik, A & Yalın, AE 2023, 'Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress', İstanbul Journal of Pharmacy, vol. 53, no. 2, pp. 159-165, viewed 9 Dec. 2023,

Harvard: Author-Date Style

Eroğlu, P. and Eke, D. and Yalın, S. and Çelik, A. and Yalın, A.E. (2023) ‘Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress’, İstanbul Journal of Pharmacy, 53(2), pp. 159-165. (9 Dec. 2023).


Eroğlu, Pelin, and Dilek Eke and Serap Yalın and Ayla Çelik and Ali Erdinç Yalın. Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress.” İstanbul Journal of Pharmacy, vol. 53, no. 2, 2023, pp. 159-165. [Database Container],


Eroğlu P, Eke D, Yalın S, Çelik A, Yalın AE. Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress. İstanbul Journal of Pharmacy [Internet]. 9 Dec. 2023 [cited 9 Dec. 2023];53(2):159-165. Available from: doi: 10.26650/IstanbulJPharm.2023.1054752


Eroğlu, Pelin - Eke, Dilek - Yalın, Serap - Çelik, Ayla - Yalın, AliErdinç. Protective effect of curcumin against perfluorooctane sulfonate induced oxidative stress”. İstanbul Journal of Pharmacy 53/2 (Dec. 2023): 159-165.


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