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DOI :10.26650/JARHS2023-1226757   IUP :10.26650/JARHS2023-1226757    Tam Metin (PDF)

MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ

Hayri CanbazHikmet Can ÇubukçuAhmet DemirFatih KacıroğluSeher TaşAlpay TuncarMehmet Ferit FedaiMurat GülşenAtilla Beştemir

Giriş: Birkaç ülke, doku onarımı ve anti-inflamatuar mekanizmalar yoluyla terapötik etkilerini göz önünde bulundurarak, Koronavirüs-19 (COVID-19) hastalarını tedavi etmek için klinik deneylerde mezenkimal kök hücreleri (MKH) kullanmıştır. Bu çalışma, COVID-19 pnömoni hastalarında MKH uygulamasının klinik ve inflamatuar parametreler ve yaşam beklentisi üzerindeki erken etkilerini araştırmak amaçladı. Gereç ve Yöntem: Türkiye Cumhuriyeti Sağlık Bakanlığı Doku, Organ Nakli ve Diyaliz Hizmetleri Daire Başkanlığı’na başvuran ve 1 Mart 2020 - 1 Mart 2021 tarihleri arasında MKH uygulaması için başvurusu olan COVID-19 pnömonisi (tüm yaş grupları) olan aşılanmamış 164 hastayı geriye dönük olarak inceledik. Bulgular: Kaplan Mayer sağkalım analizi kullanılarak, kırılım yaşı (hayatta kalma riskini önemli ölçüde artıran) 61 yıl olarak bulundu. Kadınlar erkeklere göre 1.56 kat daha fazla ölüm riskine sahipti. Hastaların %68’inde (113/164) komorbidite mevcuttu ve bu komorbiditesi olmayanlara göre ölüm riskini 1,58 kat artırıyordu. Koroner arter hastalığı varlığı ölüm riskini 1,79 kat artırdı. Ayrıca, entübe hastalarda entübe olmayanlara göre ölüm riski 7 kat daha yüksekti (%95 GA: 3.72-13.17). Maalesef hastaların %64’ü (106/164) öldü. Son olarak, MKH sonrası tedavi medyan Sıralı Organ Yetmezliği Değerlendirme Skoru (SOFA) değerlerinde uygulama sırasında, 3, 7, 14. günlerde ve sonuna kadar (taburcu/ex) istatistiksel olarak anlamlı bir artış oldu. Sonuç: Bu çalışma aşılanmamış hastalarla yapılmıştır ve COVID-19 ile ilişkili pnömoni için MKH tedavisi yeterince etkili değildir.

DOI :10.26650/JARHS2023-1226757   IUP :10.26650/JARHS2023-1226757    Tam Metin (PDF)

CLINICAL COURSE OF COVID-19 PATIENTS UNDER MESENCHYMAL STEM CELL THERAPY

Hayri CanbazHikmet Can ÇubukçuAhmet DemirFatih KacıroğluSeher TaşAlpay TuncarMehmet Ferit FedaiMurat GülşenAtilla Beştemir

Objective: Several countries have used mesenchymal stem cells (MSCs) in clinical trials for treating Coronavirus-19 (COVID-19) patients, considering their therapeutic effects through tissue repair and anti-inflammatory mechanisms. This study aimed to investigate the early effects of MSC application in COVID-19 pneumonia patients on clinical and inflammatory parameters and life expectancy. Material and Method: We retrospectively analyzed 164 unvaccinated patients with COVID-19 pneumonia (all age groups) who had applied to the Republic of Turkiye, Ministry of Health, Department of Tissue, Organ Transplantation, and Dialysis Services and received the MSC application from March 1, 2020 to March 1, 2021. Results: Using the Kaplan Mayer survival analysis, the cut-off age (which significantly increased the survival risk) was found to be 61 years. Females had a 1.56 times higher risk of death than males. Sixty-eight percent (113/164) of the patients had a comorbidity, which increased the risk of death by 1.58 times compared to those without any comorbidity. The presence of coronary artery disease increased the risk of death by 1.79 times. Further, the risk of death was 7 times higher in intubated patients than in those who were not (95% CI: 3.72–13.17). Unfortunately, 64% (106/164) of the patients died. Lastly, there was a statistically significant increase in the post-MSC treatment median Sequential Organ Failure Assessment Score (SOFA) score values at the time of application, on days 3, 7, 14, and until the end (discharge/ex). Conclusion: This study was conducted with unvaccinated patients and MSC treatment for COVID-19-related pneumonia is not adequately effective.


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DIŞA AKTAR



APA

Canbaz, H., Çubukçu, H.C., Demir, A., Kacıroğlu, F., Taş, S., Tuncar, A., Fedai, M.F., Gülşen, M., & Beştemir, A. (2023). MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 6(1), 40-45. https://doi.org/10.26650/JARHS2023-1226757


AMA

Canbaz H, Çubukçu H C, Demir A, Kacıroğlu F, Taş S, Tuncar A, Fedai M F, Gülşen M, Beştemir A. MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ. Sağlık Bilimlerinde İleri Araştırmalar Dergisi. 2023;6(1):40-45. https://doi.org/10.26650/JARHS2023-1226757


ABNT

Canbaz, H.; Çubukçu, H.C.; Demir, A.; Kacıroğlu, F.; Taş, S.; Tuncar, A.; Fedai, M.F.; Gülşen, M.; Beştemir, A. MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, [Publisher Location], v. 6, n. 1, p. 40-45, 2023.


Chicago: Author-Date Style

Canbaz, Hayri, and Hikmet Can Çubukçu and Ahmet Demir and Fatih Kacıroğlu and Seher Taş and Alpay Tuncar and Mehmet Ferit Fedai and Murat Gülşen and Atilla Beştemir. 2023. “MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 6, no. 1: 40-45. https://doi.org/10.26650/JARHS2023-1226757


Chicago: Humanities Style

Canbaz, Hayri, and Hikmet Can Çubukçu and Ahmet Demir and Fatih Kacıroğlu and Seher Taş and Alpay Tuncar and Mehmet Ferit Fedai and Murat Gülşen and Atilla Beştemir. MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 6, no. 1 (Jun. 2023): 40-45. https://doi.org/10.26650/JARHS2023-1226757


Harvard: Australian Style

Canbaz, H & Çubukçu, HC & Demir, A & Kacıroğlu, F & Taş, S & Tuncar, A & Fedai, MF & Gülşen, M & Beştemir, A 2023, 'MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ', Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 6, no. 1, pp. 40-45, viewed 5 Jun. 2023, https://doi.org/10.26650/JARHS2023-1226757


Harvard: Author-Date Style

Canbaz, H. and Çubukçu, H.C. and Demir, A. and Kacıroğlu, F. and Taş, S. and Tuncar, A. and Fedai, M.F. and Gülşen, M. and Beştemir, A. (2023) ‘MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ’, Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 6(1), pp. 40-45. https://doi.org/10.26650/JARHS2023-1226757 (5 Jun. 2023).


MLA

Canbaz, Hayri, and Hikmet Can Çubukçu and Ahmet Demir and Fatih Kacıroğlu and Seher Taş and Alpay Tuncar and Mehmet Ferit Fedai and Murat Gülşen and Atilla Beştemir. MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 6, no. 1, 2023, pp. 40-45. [Database Container], https://doi.org/10.26650/JARHS2023-1226757


Vancouver

Canbaz H, Çubukçu HC, Demir A, Kacıroğlu F, Taş S, Tuncar A, Fedai MF, Gülşen M, Beştemir A. MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ. Sağlık Bilimlerinde İleri Araştırmalar Dergisi [Internet]. 5 Jun. 2023 [cited 5 Jun. 2023];6(1):40-45. Available from: https://doi.org/10.26650/JARHS2023-1226757 doi: 10.26650/JARHS2023-1226757


ISNAD

Canbaz, Hayri - Çubukçu, HikmetCan - Demir, Ahmet - Kacıroğlu, Fatih - Taş, Seher - Tuncar, Alpay - Fedai, MehmetFerit - Gülşen, Murat - Beştemir, Atilla. MESENKİMAL KÖK HÜCRE TEDAVİSİ UYGULANAN COVID-19 HASTALARININ SEYRİ”. Sağlık Bilimlerinde İleri Araştırmalar Dergisi 6/1 (Jun. 2023): 40-45. https://doi.org/10.26650/JARHS2023-1226757



ZAMAN ÇİZELGESİ


Gönderim02.01.2023
Kabul11.01.2023
Çevrimiçi Yayınlanma16.02.2023

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