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DOI :10.26650/jchild.2023.1341346   IUP :10.26650/jchild.2023.1341346    Tam Metin (PDF)

Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience

Ezgi Paslı UysalolCengiz BayramGül Nihal ÖzdemirSibel Akpınar TekgündüzGönül AydoğanAli Ayçiçek

Objective: Acute lymphoblastic leukemia (ALL) is one of the most common malignant diseases in children. This study aimed to determine the clinical and prognostic characteristics of adolescent patients with ALL aged 15–18 years who were followed up in our center.

Materials and Methods: The clinical and laboratory characteristics, treatment responses, and survival and relapse rates of adolescent patients with ALL were retrospectively analyzed

Results: The majority of patients were male. The median age of patients was 16 (range 15–17.9) years. About 36% and 74% of patients were diagnosed with T- and B-cell ALLs, respectively. Then, 32% of patients were stratified in the high-risk group. BCR/ABL t (9;22) positivity was detected in one patient. Recurrence was observed in 6 of 31 patients after completing the treatment. The estimated survival rate in the high-risk group at 32 months was 58%.

Conclusion: Ihe prognosis and outcomes of ALL in adolescent and young adult patients are poor compared to younger age groups. Future clinical trials and advance in chemotherapeutic protocols in this age group will help increase the treatment success rates

Anahtar Kelimeler: adolescentleukemiasurvival
DOI :10.26650/jchild.2023.1341346   IUP :10.26650/jchild.2023.1341346    Tam Metin (PDF)

Adolesan Akut Lenfoblastik Lösemileri: Geriye Dönük Tek Merkez Deneyimi

Ezgi Paslı UysalolCengiz BayramGül Nihal ÖzdemirSibel Akpınar TekgündüzGönül AydoğanAli Ayçiçek

Amaç: Akut lenfoblastik lösemi (ALL) çocukluk çağında en sık rastlanan habis hastalıklardan biridir. Çalışmamızda merkezimizde ALL tanısı ile takip ve tedavi edilen, 15-18 yaş arası adölesan hastaların klinik ve prognostik özelliklerini belirlemeyi amaçladık.

Gereç ve Yöntem: ALL’li adolesan hastaların klinik ve laboratuvar özellikleri, tedavi yanıtları, sağkalım ve nüks oranları retrospektif olarak analiz edildi.

Bulgular: Hastaların çoğunluğunu erkekler oluşturmaktaydı.Median yaş değeri 16 (15-17,9) yıl idi. Hastaların %32’si yüksek risk grubundaydı ve %26’sı T hücreli ALL %74’ü B hücreli ALL immunfenotipi göstermekteydi. BCRL/ABL t (9;22) pozitifliği bir hastada saptandı. Altı hastamızda tedavi bitimi sonrası nüks görüldü. Yüksek risk grubunda otuz ikinci ayda tahmini sağ kalım oranı %58 idi.

Sonuç: Ergen ve genç yetişkin hastaların prognozu ve sonuçları diğer küçük yaş gruplarından farklı olarak daha kötüdür. Çocukluk çağında kullanılan protokollerin, bu yaş grubuna özel klinik araştırmalarla geliştirilmesi tedavide başarı oranlarının artmasına katkı sağlayacaktır.

Anahtar Kelimeler: adolesançocuksağkalım

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APA

Paslı Uysalol, E., Bayram, C., Özdemir, G.N., Akpınar Tekgündüz, S., Aydoğan, G., & Ayçiçek, A. (2023). Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience. Çocuk Dergisi, 23(3), 265-269. https://doi.org/10.26650/jchild.2023.1341346


AMA

Paslı Uysalol E, Bayram C, Özdemir G N, Akpınar Tekgündüz S, Aydoğan G, Ayçiçek A. Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience. Çocuk Dergisi. 2023;23(3):265-269. https://doi.org/10.26650/jchild.2023.1341346


ABNT

Paslı Uysalol, E.; Bayram, C.; Özdemir, G.N.; Akpınar Tekgündüz, S.; Aydoğan, G.; Ayçiçek, A. Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience. Çocuk Dergisi, [Publisher Location], v. 23, n. 3, p. 265-269, 2023.


Chicago: Author-Date Style

Paslı Uysalol, Ezgi, and Cengiz Bayram and Gül Nihal Özdemir and Sibel Akpınar Tekgündüz and Gönül Aydoğan and Ali Ayçiçek. 2023. “Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience.” Çocuk Dergisi 23, no. 3: 265-269. https://doi.org/10.26650/jchild.2023.1341346


Chicago: Humanities Style

Paslı Uysalol, Ezgi, and Cengiz Bayram and Gül Nihal Özdemir and Sibel Akpınar Tekgündüz and Gönül Aydoğan and Ali Ayçiçek. Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience.” Çocuk Dergisi 23, no. 3 (Mar. 2024): 265-269. https://doi.org/10.26650/jchild.2023.1341346


Harvard: Australian Style

Paslı Uysalol, E & Bayram, C & Özdemir, GN & Akpınar Tekgündüz, S & Aydoğan, G & Ayçiçek, A 2023, 'Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience', Çocuk Dergisi, vol. 23, no. 3, pp. 265-269, viewed 3 Mar. 2024, https://doi.org/10.26650/jchild.2023.1341346


Harvard: Author-Date Style

Paslı Uysalol, E. and Bayram, C. and Özdemir, G.N. and Akpınar Tekgündüz, S. and Aydoğan, G. and Ayçiçek, A. (2023) ‘Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience’, Çocuk Dergisi, 23(3), pp. 265-269. https://doi.org/10.26650/jchild.2023.1341346 (3 Mar. 2024).


MLA

Paslı Uysalol, Ezgi, and Cengiz Bayram and Gül Nihal Özdemir and Sibel Akpınar Tekgündüz and Gönül Aydoğan and Ali Ayçiçek. Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience.” Çocuk Dergisi, vol. 23, no. 3, 2023, pp. 265-269. [Database Container], https://doi.org/10.26650/jchild.2023.1341346


Vancouver

Paslı Uysalol E, Bayram C, Özdemir GN, Akpınar Tekgündüz S, Aydoğan G, Ayçiçek A. Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience. Çocuk Dergisi [Internet]. 3 Mar. 2024 [cited 3 Mar. 2024];23(3):265-269. Available from: https://doi.org/10.26650/jchild.2023.1341346 doi: 10.26650/jchild.2023.1341346


ISNAD

Paslı Uysalol, Ezgi - Bayram, Cengiz - Özdemir, GülNihal - Akpınar Tekgündüz, Sibel - Aydoğan, Gönül - Ayçiçek, Ali. Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience”. Çocuk Dergisi 23/3 (Mar. 2024): 265-269. https://doi.org/10.26650/jchild.2023.1341346



ZAMAN ÇİZELGESİ


Gönderim11.08.2023
Kabul19.08.2023
Çevrimiçi Yayınlanma24.10.2023

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