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DOI :10.26650/IUITFD.2021.847530   IUP :10.26650/IUITFD.2021.847530    Tam Metin (PDF)

ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ

Cemile PehlivanoğluZeynep Nagehan Yürük YıldırımAlev YılmazAsuman GedikbaşıNurinisa KaragözNurver AkıncıAysel KıyakGül ÖzçelikYasemin ÖzlükIşın KılıçaslanAyşe Ayşim ÖzağarıBağdagül Yavaş AksuSevinç Emre

Amaç: Deneysel ve epidemiyolojik çalışmalar, yüksek serum homosistein düzeylerinin renal hasara yol açabileceğini ve kronik böbrek hastalığı gelişimi için önemli bir risk faktörü olabileceğini göstermektedir. Çalışmamızın amacı IgA nefropatisi ve HenochSchönlein purpura nefriti olan hastalarda serum homosistein düzeyleri ile kresent oluşumu arasında bir ilişki olup olmadığını belirlemektir. Gereç ve Yöntemler: Üç pediatrik nefroloji merkezinde son beş yılda biyopsi ile IgA nefropatisi, Henoch-Schönlein purpura nefriti ve idiopatik kresentik glomerulonefrit tanısı alan 31 hasta ve 25 sağlıklı kontrol çalışmaya alındı. Bulgular: Hastaların homosistein düzeyleri normal değerin üst sınırından ve kontrollerden de daha yüksekti (p=0,0001). Biyopside kresent görülen ve görülmeyen hastalar arasında da homosistein düzeyleri açısından anlamlı fark yoktu (p>0,05). Proteinüri varlığı ve şiddeti ile homosistein düzeyleri arasında ilişki saptanmadı (p>0,05). Sonuç: Serum homosistein düzeyleri IgA nefropatisi ve HenochSchonlein purpura nefriti olan hastalarda yüksek bulunmuştur. Sonuçlarımız, bu hasta grubunda yüksek serum homosistein düzeylerinin segmental glomerüloskleroz ile ilişkili olabileceğini düşündürmektedir.

Anahtar Kelimeler: IgA nefropatisihomosisteinkresent
DOI :10.26650/IUITFD.2021.847530   IUP :10.26650/IUITFD.2021.847530    Tam Metin (PDF)

A POSSIBLE RELATIONSHIP BETWEEN SERUM HOMOCYSTEINE LEVEL AND IgA NEPHROPATHY IN CHILDREN

Cemile PehlivanoğluZeynep Nagehan Yürük YıldırımAlev YılmazAsuman GedikbaşıNurinisa KaragözNurver AkıncıAysel KıyakGül ÖzçelikYasemin ÖzlükIşın KılıçaslanAyşe Ayşim ÖzağarıBağdagül Yavaş AksuSevinç Emre

Objective: The evidences from experimental and epidemiological studies suggests that elevated serum homocysteine levels may lead to renal injury and may be a significant risk factor for the development of chronic kidney disease. The aim of this study was to investigate a possible relationship between serum homocysteine level and crescent formation in children with IgA nephropathy and Henoch-Schonlein purpura nephritis. Material and Methods: A total of 31 patients diagnosed as biopsy proven IgA nephropathy and Henoch-Schonlein purpura nephritis and idiopathic crescentic glomerulonephritis in three Pediatric Nephrology centers within the last five years and 25 healthy controls were enrolled in the study. Results: Homocysteine levels of patients were higher than the upper limit of normal value and also higher than the controls (p=0.0001). There was no significant difference between the patients with or without crescent formation regarding homocysteine levels (p>0.05). Presence or severity of proteinuria was not related to homocysteine levels (p>0.05). Conclusion: Serum homocysteine levels are elevated in patients with IgA nephropathy and Henoch-Schonlein purpura nephritis. Our results suggest that elevated serum homocysteine levels may be related to segmental glomerulosclerosis in these patient groups.

Anahtar Kelimeler: IgA nephropathyhomocysteinecrescent

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DIŞA AKTAR



APA

Pehlivanoğlu, C., Yürük Yıldırım, Z.N., Yılmaz, A., Gedikbaşı, A., Karagöz, N., Akıncı, N., Kıyak, A., Özçelik, G., Özlük, Y., Kılıçaslan, I., Özağarı, A.A., Yavaş Aksu, B., & Emre, S. (2021). ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ. İstanbul Tıp Fakültesi Dergisi, 84(4), 568-573. https://doi.org/10.26650/IUITFD.2021.847530


AMA

Pehlivanoğlu C, Yürük Yıldırım Z N, Yılmaz A, Gedikbaşı A, Karagöz N, Akıncı N, Kıyak A, Özçelik G, Özlük Y, Kılıçaslan I, Özağarı A A, Yavaş Aksu B, Emre S. ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ. İstanbul Tıp Fakültesi Dergisi. 2021;84(4):568-573. https://doi.org/10.26650/IUITFD.2021.847530


ABNT

Pehlivanoğlu, C.; Yürük Yıldırım, Z.N.; Yılmaz, A.; Gedikbaşı, A.; Karagöz, N.; Akıncı, N.; Kıyak, A.; Özçelik, G.; Özlük, Y.; Kılıçaslan, I.; Özağarı, A.A.; Yavaş Aksu, B.; Emre, S. ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ. İstanbul Tıp Fakültesi Dergisi, [Publisher Location], v. 84, n. 4, p. 568-573, 2021.


Chicago: Author-Date Style

Pehlivanoğlu, Cemile, and Zeynep Nagehan Yürük Yıldırım and Alev Yılmaz and Asuman Gedikbaşı and Nurinisa Karagöz and Nurver Akıncı and Aysel Kıyak and Gül Özçelik and Yasemin Özlük and Işın Kılıçaslan and Ayşe Ayşim Özağarı and Bağdagül Yavaş Aksu and Sevinç Emre. 2021. “ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ.” İstanbul Tıp Fakültesi Dergisi 84, no. 4: 568-573. https://doi.org/10.26650/IUITFD.2021.847530


Chicago: Humanities Style

Pehlivanoğlu, Cemile, and Zeynep Nagehan Yürük Yıldırım and Alev Yılmaz and Asuman Gedikbaşı and Nurinisa Karagöz and Nurver Akıncı and Aysel Kıyak and Gül Özçelik and Yasemin Özlük and Işın Kılıçaslan and Ayşe Ayşim Özağarı and Bağdagül Yavaş Aksu and Sevinç Emre. ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ.” İstanbul Tıp Fakültesi Dergisi 84, no. 4 (Jan. 2022): 568-573. https://doi.org/10.26650/IUITFD.2021.847530


Harvard: Australian Style

Pehlivanoğlu, C & Yürük Yıldırım, ZN & Yılmaz, A & Gedikbaşı, A & Karagöz, N & Akıncı, N & Kıyak, A & Özçelik, G & Özlük, Y & Kılıçaslan, I & Özağarı, AA & Yavaş Aksu, B & Emre, S 2021, 'ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ', İstanbul Tıp Fakültesi Dergisi, vol. 84, no. 4, pp. 568-573, viewed 20 Jan. 2022, https://doi.org/10.26650/IUITFD.2021.847530


Harvard: Author-Date Style

Pehlivanoğlu, C. and Yürük Yıldırım, Z.N. and Yılmaz, A. and Gedikbaşı, A. and Karagöz, N. and Akıncı, N. and Kıyak, A. and Özçelik, G. and Özlük, Y. and Kılıçaslan, I. and Özağarı, A.A. and Yavaş Aksu, B. and Emre, S. (2021) ‘ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ’, İstanbul Tıp Fakültesi Dergisi, 84(4), pp. 568-573. https://doi.org/10.26650/IUITFD.2021.847530 (20 Jan. 2022).


MLA

Pehlivanoğlu, Cemile, and Zeynep Nagehan Yürük Yıldırım and Alev Yılmaz and Asuman Gedikbaşı and Nurinisa Karagöz and Nurver Akıncı and Aysel Kıyak and Gül Özçelik and Yasemin Özlük and Işın Kılıçaslan and Ayşe Ayşim Özağarı and Bağdagül Yavaş Aksu and Sevinç Emre. ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ.” İstanbul Tıp Fakültesi Dergisi, vol. 84, no. 4, 2021, pp. 568-573. [Database Container], https://doi.org/10.26650/IUITFD.2021.847530


Vancouver

Pehlivanoğlu C, Yürük Yıldırım ZN, Yılmaz A, Gedikbaşı A, Karagöz N, Akıncı N, Kıyak A, Özçelik G, Özlük Y, Kılıçaslan I, Özağarı AA, Yavaş Aksu B, Emre S. ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ. İstanbul Tıp Fakültesi Dergisi [Internet]. 20 Jan. 2022 [cited 20 Jan. 2022];84(4):568-573. Available from: https://doi.org/10.26650/IUITFD.2021.847530 doi: 10.26650/IUITFD.2021.847530


ISNAD

Pehlivanoğlu, Cemile - Yürük Yıldırım, ZeynepNagehan - Yılmaz, Alev - Gedikbaşı, Asuman - Karagöz, Nurinisa - Akıncı, Nurver - Kıyak, Aysel - Özçelik, Gül - Özlük, Yasemin - Kılıçaslan, Işın - Özağarı, AyşeAyşim - Yavaş Aksu, Bağdagül - Emre, Sevinç. ÇOCUKLARDA SERUM HOMOSİSTEİN DÜZEYİ İLE IgA NEFROPATİSİ ARASINDAKİ OLASI İLİŞKİ”. İstanbul Tıp Fakültesi Dergisi 84/4 (Jan. 2022): 568-573. https://doi.org/10.26650/IUITFD.2021.847530



ZAMAN ÇİZELGESİ


Gönderim29.12.2020
Kabul06.07.2021
Çevrimiçi Yayınlanma29.09.2021

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