The Turkish Journal of Ear Nose and Throat

TR-ENT

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DOI :10.26650/Tr-ENT.2024.1479029   IUP :10.26650/Tr-ENT.2024.1479029    Tam Metin (PDF)

Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment

Hülya Hacişahinoğulları, Gamze Bilik Oyman, Duygu Dölen, Menekşe Bilge Bilgiç, Rasim Meral, Gülşah Yenidünya Yalın, Nurdan Gül, Ayşe Kubat Üzüm, Özlem Soyluk Selçukbiricik

Objective: Craniopharyngioma (CP) is benign, but its treatment is challenging because of its occurrence in a critical area. Hypothalamic-pituitary dysfunction (HPD) is an important complication that is related to tumour itself or to therapy. This study identified the long-term outcomes of CPs.

Material and Methods: Records of 44 patients with CPs followed up at the Istanbul Faculty of Medicine were retrospectively reviewed.

Results: The mean age of 34 patients (M/F: 19/15) at diagnosis was 24±13.3 years. The most common symptoms were headache (60.3%) and visual impairment (45.5%). The tumour was localised in suprasellar region in 76.6%, in sellar-suprasellar in 16.7%, and in the sellar region in 6.7% of the patients. The mean tumour diameter was 32.7±10.4 mm (n: 19). Surgery was the first line of treatment in all patients except one, and 13 patients underwent more than one operation. Ten patients received radiotherapy. The median duration of follow-up was 6.5 years. Anterior pituitary dysfunction was observed in all patients: hypocortisolism in 88.2%, hypothyroidism in 97%, hypogonadism in 88.2%, growth hormone deficiency in 68.2%, and prolactin deficiency in 20.6% of the patients. Diabetes insipidus occurred in 97% of the patients. Recurrence developed in 2 patients (after 5-6 years). At the end of all treatments, 15 patients had residual disease.

Conclusion: The curative treatment of CP is surgery. HPD is associated with increased mortality and morbidity and decreased quality of life. It is essential to protect the hipothalamo-pituitary axis and to choose the best treatment option for each patient.

Anahtar Kelimeler: Craniopharyngioma, hormone, pituitary, hormone deficiency, hypothalamus

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APA

Hacişahinoğulları, H., Bilik Oyman, G., Dölen, D., Bilgiç, M.B., Meral, R., Yenidünya Yalın, G., Gül, N., Kubat Üzüm, A., & Soyluk Selçukbiricik, Ö. (2024). Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment. The Turkish Journal of Ear Nose and Throat, 34(2), 60-65. https://doi.org/10.26650/Tr-ENT.2024.1479029


AMA

Hacişahinoğulları H, Bilik Oyman G, Dölen D, Bilgiç M B, Meral R, Yenidünya Yalın G, Gül N, Kubat Üzüm A, Soyluk Selçukbiricik Ö. Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment. The Turkish Journal of Ear Nose and Throat. 2024;34(2):60-65. https://doi.org/10.26650/Tr-ENT.2024.1479029


ABNT

Hacişahinoğulları, H.; Bilik Oyman, G.; Dölen, D.; Bilgiç, M.B.; Meral, R.; Yenidünya Yalın, G.; Gül, N.; Kubat Üzüm, A.; Soyluk Selçukbiricik, Ö. Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment. The Turkish Journal of Ear Nose and Throat, [Publisher Location], v. 34, n. 2, p. 60-65, 2024.


Chicago: Author-Date Style

Hacişahinoğulları, Hülya, and Gamze Bilik Oyman and Duygu Dölen and Menekşe Bilge Bilgiç and Rasim Meral and Gülşah Yenidünya Yalın and Nurdan Gül and Ayşe Kubat Üzüm and Özlem Soyluk Selçukbiricik. 2024. “Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment.” The Turkish Journal of Ear Nose and Throat 34, no. 2: 60-65. https://doi.org/10.26650/Tr-ENT.2024.1479029


Chicago: Humanities Style

Hacişahinoğulları, Hülya, and Gamze Bilik Oyman and Duygu Dölen and Menekşe Bilge Bilgiç and Rasim Meral and Gülşah Yenidünya Yalın and Nurdan Gül and Ayşe Kubat Üzüm and Özlem Soyluk Selçukbiricik. “Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment.” The Turkish Journal of Ear Nose and Throat 34, no. 2 (Sep. 2024): 60-65. https://doi.org/10.26650/Tr-ENT.2024.1479029


Harvard: Australian Style

Hacişahinoğulları, H & Bilik Oyman, G & Dölen, D & Bilgiç, MB & Meral, R & Yenidünya Yalın, G & Gül, N & Kubat Üzüm, A & Soyluk Selçukbiricik, Ö 2024, 'Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment', The Turkish Journal of Ear Nose and Throat, vol. 34, no. 2, pp. 60-65, viewed 12 Sep. 2024, https://doi.org/10.26650/Tr-ENT.2024.1479029


Harvard: Author-Date Style

Hacişahinoğulları, H. and Bilik Oyman, G. and Dölen, D. and Bilgiç, M.B. and Meral, R. and Yenidünya Yalın, G. and Gül, N. and Kubat Üzüm, A. and Soyluk Selçukbiricik, Ö. (2024) ‘Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment’, The Turkish Journal of Ear Nose and Throat, 34(2), pp. 60-65. https://doi.org/10.26650/Tr-ENT.2024.1479029 (12 Sep. 2024).


MLA

Hacişahinoğulları, Hülya, and Gamze Bilik Oyman and Duygu Dölen and Menekşe Bilge Bilgiç and Rasim Meral and Gülşah Yenidünya Yalın and Nurdan Gül and Ayşe Kubat Üzüm and Özlem Soyluk Selçukbiricik. “Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment.” The Turkish Journal of Ear Nose and Throat, vol. 34, no. 2, 2024, pp. 60-65. [Database Container], https://doi.org/10.26650/Tr-ENT.2024.1479029


Vancouver

Hacişahinoğulları H, Bilik Oyman G, Dölen D, Bilgiç MB, Meral R, Yenidünya Yalın G, Gül N, Kubat Üzüm A, Soyluk Selçukbiricik Ö. Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment. The Turkish Journal of Ear Nose and Throat [Internet]. 12 Sep. 2024 [cited 12 Sep. 2024];34(2):60-65. Available from: https://doi.org/10.26650/Tr-ENT.2024.1479029 doi: 10.26650/Tr-ENT.2024.1479029


ISNAD

Hacişahinoğulları, Hülya - Bilik Oyman, Gamze - Dölen, Duygu - Bilgiç, MenekşeBilge - Meral, Rasim - Yenidünya Yalın, Gülşah - Gül, Nurdan - Kubat Üzüm, Ayşe - Soyluk Selçukbiricik, Özlem. “Characteristics of Patients with Craniopharyngioma and LongTerm Outcomes of Treatment”. The Turkish Journal of Ear Nose and Throat 34/2 (Sep. 2024): 60-65. https://doi.org/10.26650/Tr-ENT.2024.1479029



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